Genular: Defining Cellular Identity and Function

Details for: Stx4a

Gene ID: 20909

Symbol: Stx4a

Ensembl ID: ENSMUSG00000030805

Description: syntaxin 4A (placental)

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing-cross presentation
(R-MMU-1236975)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Cytokine signaling in immune system
(R-MMU-1280215)
Disinhibition of snare formation
(R-MMU-114516)
Er-phagosome pathway
(R-MMU-1236974)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Membrane trafficking
(R-MMU-199991)
Other interleukin signaling
(R-MMU-449836)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Signaling by interleukins
(R-MMU-449147)
Trans-golgi network vesicle budding
(R-MMU-199992)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to type ii interferon
(GO:0071346)
Cornified envelope assembly
(GO:1903575)
Cytoplasm
(GO:0005737)
Dendritic spine
(GO:0043197)
Endomembrane system
(GO:0012505)
Endosome
(GO:0005768)
Exocytic insertion of neurotransmitter receptor to postsynaptic membrane
(GO:0098967)
Exocytosis
(GO:0006887)
Extracellular space
(GO:0005615)
Glutamatergic synapse
(GO:0098978)
Intracellular protein transport
(GO:0006886)
Lamellipodium
(GO:0030027)
Lateral loop
(GO:0043219)
Long-term synaptic potentiation
(GO:0060291)
Membrane
(GO:0016020)
Membrane fusion
(GO:0061025)
Myelin sheath adaxonal region
(GO:0035749)
Neuron projection membrane
(GO:0032589)
Neurotransmitter transport
(GO:0006836)
Organelle fusion
(GO:0048284)
Perinuclear region of cytoplasm
(GO:0048471)
Phagocytic vesicle
(GO:0045335)
Plasma membrane
(GO:0005886)
Positive regulation of catalytic activity
(GO:0043085)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chemotaxis
(GO:0050921)
Positive regulation of eosinophil degranulation
(GO:0043311)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of protein localization to cell surface
(GO:2000010)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Postsynapse
(GO:0098794)
Postsynaptic membrane
(GO:0045211)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Protein localization to cell surface
(GO:0034394)
Regulation of exocytosis
(GO:0017157)
Regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902041)
Sarcolemma
(GO:0042383)
Schaffer collateral - ca1 synapse
(GO:0098685)
Small gtpase binding
(GO:0031267)
Snap receptor activity
(GO:0005484)
Snare binding
(GO:0000149)
Snare complex
(GO:0031201)
Snare complex assembly
(GO:0035493)
Somatodendritic compartment
(GO:0036477)
Specific granule
(GO:0042581)
Sphingomyelin phosphodiesterase activator activity
(GO:0016230)
Storage vacuole
(GO:0000322)
Synapse
(GO:0045202)
Synaptic vesicle docking
(GO:0016081)
Synaptic vesicle exocytosis
(GO:0016079)
Trans-golgi network
(GO:0005802)
Vesicle-mediated transport
(GO:0016192)
Vesicle-mediated transport in synapse
(GO:0099003)
Vesicle docking
(GO:0048278)
Vesicle fusion
(GO:0006906)

Other Information

Proteins

Syntaxin-4

Genular Protein ID: 3953296755

Symbol: STX4_MOUSE

Name: Syntaxin-4

UniProtKB Accession Codes:

P70452 Q3TSL5 Q3UKQ8 Q80WT8

Database IDs:

Citations:

PubMed ID: 9045631

Title: Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4.

PubMed ID: 9045631

DOI: 10.1074/jbc.272.10.6179

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10394363

Title: Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes.

PubMed ID: 10394363

DOI: 10.1016/s1097-2765(01)80007-1

PubMed ID: 12877659

Title: Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells.

PubMed ID: 12877659

DOI: 10.1042/bj20030427

PubMed ID: 15363411

Title: A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells.

PubMed ID: 15363411

DOI: 10.1016/j.devcel.2004.08.002

PubMed ID: 11809830

Title: Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells.

PubMed ID: 11809830

DOI: 10.1091/mbc.01-10-0496

PubMed ID: 17548353

Title: Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis.

PubMed ID: 17548353

DOI: 10.1074/jbc.m701661200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18827011

Title: Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport.

PubMed ID: 18827011

DOI: 10.1242/jcs.032847

PubMed ID: 19033398

Title: DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes.

PubMed ID: 19033398

DOI: 10.2337/db08-0303

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21998599

Title: Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion.

PubMed ID: 21998599

DOI: 10.1371/journal.pgen.1002323

Sequence Information:

Length: 298
Mass: 34165
Checksum: FCD1477E1126CEC1
Sequence:

MRDRTHELRQ GDNISDDEDE VRVALVVHSG AARLGSPDDE FFQKVQTIRQ TMAKLESKVR 
ELEKQQVTIL ATPLPEESMK QGLQNLREEI KQLGREVRAQ LKAIEPQKEE ADENYNSVNT 
RMKKTQHGVL SQQFVELINK CNSMQSEYRE KNVERIRRQL KITNAGMVSD EELEQMLDSG 
QSEVFVSNIL KDTQVTRQAL NEISARHSEI QQLERSIREL HEIFTFLATE VEMQGEMINR 
IEKNILSSAD YVERGQEHVK IALENQKKAR KKKVMIAICV SVTVLILAVI IGITITVG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Stx4a

Associated with

Other Information

Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. PubMed ID: 9045631

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. PubMed ID: 10394363

Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells. PubMed ID: 12877659

A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells. PubMed ID: 15363411

Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells. PubMed ID: 11809830

Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis. PubMed ID: 17548353

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport. PubMed ID: 18827011

DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes. PubMed ID: 19033398

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. PubMed ID: 21998599