Genular: Defining Cellular Identity and Function

Details for: Stxbp1

Gene ID: 20910

Symbol: Stxbp1

Ensembl ID: ENSMUSG00000026797

Description: syntaxin binding protein 1

Associated with

Acetylcholine neurotransmitter release cycle
(R-MMU-264642)
Dopamine neurotransmitter release cycle
(R-MMU-212676)
Gaba synthesis, release, reuptake and degradation
(R-MMU-888590)
Glutamate neurotransmitter release cycle
(R-MMU-210500)
Neuronal system
(R-MMU-112316)
Neurotransmitter release cycle
(R-MMU-112310)
Norepinephrine neurotransmitter release cycle
(R-MMU-181430)
Serotonin neurotransmitter release cycle
(R-MMU-181429)
Transmission across chemical synapses
(R-MMU-112315)
Axon
(GO:0030424)
Axon target recognition
(GO:0007412)
Cellular response to type ii interferon
(GO:0071346)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Developmental process involved in reproduction
(GO:0003006)
Establishment of localization in cell
(GO:0051649)
Exocytosis
(GO:0006887)
Extrinsic component of presynaptic membrane
(GO:0098888)
Glutamatergic synapse
(GO:0098978)
Identical protein binding
(GO:0042802)
Intracellular protein transport
(GO:0006886)
Long-term synaptic depression
(GO:0060292)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Molecular adaptor activity
(GO:0060090)
Myelin sheath
(GO:0043209)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Negative regulation of synaptic transmission, gabaergic
(GO:0032229)
Neuromuscular synaptic transmission
(GO:0007274)
Neuron apoptotic process
(GO:0051402)
Neurotransmitter secretion
(GO:0007269)
Nucleoplasm
(GO:0005654)
Parallel fiber to purkinje cell synapse
(GO:0098688)
Perinuclear region of cytoplasm
(GO:0048471)
Phagocytic vesicle
(GO:0045335)
Phospholipase binding
(GO:0043274)
Plasma membrane
(GO:0005886)
Platelet aggregation
(GO:0070527)
Platelet alpha granule
(GO:0031091)
Platelet degranulation
(GO:0002576)
Positive regulation of calcium ion-dependent exocytosis
(GO:0045956)
Positive regulation of exocytosis
(GO:0045921)
Positive regulation of glutamate secretion, neurotransmission
(GO:1903296)
Positive regulation of mast cell degranulation
(GO:0043306)
Positive regulation of vesicle docking
(GO:0106022)
Postsynapse
(GO:0098794)
Presynapse
(GO:0098793)
Presynaptic active zone cytoplasmic component
(GO:0098831)
Presynaptic active zone membrane
(GO:0048787)
Presynaptic cytosol
(GO:0099523)
Presynaptic dense core vesicle exocytosis
(GO:0099525)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Protein localization to plasma membrane
(GO:0072659)
Protein stabilization
(GO:0050821)
Protein transport
(GO:0015031)
Regulation of acrosomal vesicle exocytosis
(GO:2000367)
Regulation of synaptic vesicle priming
(GO:0010807)
Regulation of vesicle fusion
(GO:0031338)
Secretory granule
(GO:0030141)
Snare binding
(GO:0000149)
Snare complex assembly
(GO:0035493)
Synaptic vesicle fusion to presynaptic active zone membrane
(GO:0031629)
Synaptic vesicle maturation
(GO:0016188)
Synaptic vesicle priming
(GO:0016082)
Syntaxin-1 binding
(GO:0017075)
Syntaxin binding
(GO:0019905)
Vesicle-mediated transport
(GO:0016192)
Vesicle docking involved in exocytosis
(GO:0006904)

Other Information

Proteins

Syntaxin-binding protein 1

Genular Protein ID: 2095641604

Symbol: STXB1_MOUSE

Name: Syntaxin-binding protein 1

UniProtKB Accession Codes:

O08599 A2ARS2 A2ARS3 A2ARS4 Q5WAC6 Q8VD51

Database IDs:

Citations:

PubMed ID: 8824310

Title: A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants.

PubMed ID: 8824310

DOI: 10.1523/jneurosci.16-21-06695.1996

PubMed ID: 9705297

Title: Genomic structure of MUNC18-1 protein, which is involved in docking and fusion of synaptic vesicles in brain.

PubMed ID: 9705297

DOI: 10.1074/jbc.273.34.21642

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22039235

Title: Insight into the role of Ca2+-binding protein 5 in vesicle exocytosis.

PubMed ID: 22039235

DOI: 10.1167/iovs.11-8246

PubMed ID: 21445306

Title: Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis.

PubMed ID: 21445306

DOI: 10.1371/journal.pone.0017999

PubMed ID: 28821673

Title: UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.

PubMed ID: 28821673

DOI: 10.1523/jneurosci.0338-17.2017

Sequence Information:

Length: 594
Mass: 67569
Checksum: 2DD0715F875CE0F3
Sequence:

MAPIGLKAVV GEKIMHDVIK KVKKKGEWKV LVVDQLSMRM LSSCCKMTDI MTEGITIVED 
INKRREPLPS LEAVYLITPS EKSVHSLISD FKDPPTAKYR AAHVFFTDSC PDALFNELVK 
SRAAKVIKTL TEINIAFLPY ESQVYSLDSA DSFQSFYSPH KAQMKNPILE RLAEQIATLC 
ATLKEYPAVR YRGEYKDNAL LAQLIQDKLD AYKADDPTMG EGPDKARSQL LILDRGFDPS 
SPVLHELTFQ AMSYDLLPIE NDVYKYETSG IGEARVKEVL LDEDDDLWIA LRHKHIAEVS 
QEVTRSLKDF SSSKRMNTGE KTTMRDLSQM LKKMPQYQKE LSKYSTHLHL AEDCMKHYQG 
TVDKLCRVEQ DLAMGTDAEG EKIKDPMRAI VPILLDANVS TYDKIRIILL YIFLKNGITE 
ENLNKLIQHA QIPPEDSEII TNMAHLGVPI VTDSTLRRRS KPERKERISE QTYQLSRWTP 
IIKDIMEDTI EDKLDTKHYP YISTRSSASF STTAVSARYG HWHKNKAPGE YRSGPRLIIF 
ILGGVSLNEM RCAYEVTQAN GKWEVLIGST HILTPQKLLD TLKKLNKTDE EISS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Stxbp1

Associated with

Other Information

A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants. PubMed ID: 8824310

Genomic structure of MUNC18-1 protein, which is involved in docking and fusion of synaptic vesicles in brain. PubMed ID: 9705297

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Insight into the role of Ca2+-binding protein 5 in vesicle exocytosis. PubMed ID: 22039235

Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis. PubMed ID: 21445306

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans. PubMed ID: 28821673