Details for: Syk
Associated with
Other Information
Genular Protein ID: 1089175055
Symbol: KSYK_MOUSE
Name: Tyrosine-protein kinase SYK
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7477352
Title: Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk.
PubMed ID: 7477352
DOI: 10.1038/378298a0
PubMed ID: 7639745
Title: Molecular characterization of the murine syk protein tyrosine kinase cDNA, transcripts and protein.
PubMed ID: 7639745
PubMed ID: 7513017
Title: Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.
PubMed ID: 7513017
PubMed ID: 7538118
Title: Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation.
PubMed ID: 7538118
PubMed ID: 7477353
Title: Syk tyrosine kinase required for mouse viability and B-cell development.
PubMed ID: 7477353
DOI: 10.1038/378303a0
PubMed ID: 9171347
Title: The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.
PubMed ID: 9171347
PubMed ID: 11672534
Title: Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr.
PubMed ID: 11672534
PubMed ID: 12077122
Title: Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase.
PubMed ID: 12077122
PubMed ID: 11940607
Title: Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
PubMed ID: 11940607
PubMed ID: 12771181
Title: Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.
PubMed ID: 12771181
DOI: 10.1084/jem.20021686
PubMed ID: 12522250
Title: Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.
PubMed ID: 12522250
PubMed ID: 15143214
Title: NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling.
PubMed ID: 15143214
PubMed ID: 15956283
Title: Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
PubMed ID: 15956283
PubMed ID: 15845454
Title: Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.
PubMed ID: 15845454
PubMed ID: 16174766
Title: A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.
PubMed ID: 16174766
PubMed ID: 16456001
Title: Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
PubMed ID: 16456001
PubMed ID: 17086186
Title: Integrin signaling in neutrophils and macrophages uses adapters containing immunoreceptor tyrosine-based activation motifs.
PubMed ID: 17086186
DOI: 10.1038/ni1407
PubMed ID: 17353363
Title: Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption.
PubMed ID: 17353363
PubMed ID: 17947660
Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
PubMed ID: 17947660
PubMed ID: 18369315
Title: The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.
PubMed ID: 18369315
PubMed ID: 19797524
Title: Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
PubMed ID: 19797524
PubMed ID: 19124738
Title: RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells.
PubMed ID: 19124738
PubMed ID: 19339971
Title: Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
PubMed ID: 19339971
DOI: 10.1038/nature07965
PubMed ID: 19219027
Title: Identification of a dendritic cell receptor that couples sensing of necrosis to immunity.
PubMed ID: 19219027
DOI: 10.1038/nature07750
PubMed ID: 19098920
Title: Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils.
PubMed ID: 19098920
DOI: 10.1038/ni.1686
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 22496641
Title: CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex.
PubMed ID: 22496641
PubMed ID: 26195794
Title: Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.
PubMed ID: 26195794
PubMed ID: 33782605
Title: Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.
PubMed ID: 33782605
Sequence Information:
- Length: 629
- Mass: 71376
- Checksum: 2F98D21601F8224E
- Sequence:
MAGSAVDSAN HLTYFFGNIT REEAEDYLVQ GGMTDGLYLL RQSRNYLGGF ALSVAHNRKA HHYTIERELN GTYAISGGRA HASPADLCHY HSQEPDGLIC LLKKPFNRPP GVQPKTGPFE DLKENLIREY VKQTWNLQGQ ALEQAIISQK PQLEKLIATT AHEKMPWFHG NISRDESEQT VLIGSKTNGK FLIRARDNSG SYALCLLHEG KVLHYRIDRD KTGKLSIPEG KKFDTLWQLV EHYSYKPDGL LRVLTVPCQK IGAQMGHPGS PNAHPVTWSP GGIISRIKSY SFPKPGHKKP APPQGSRPES TVSFNPYEPT GGPWGPDRGL QREALPMDTE VYESPYADPE EIRPKEVYLD RSLLTLEDNE LGSGNFGTVK KGYYQMKKVV KTVAVKILKN EANDPALKDE LLAEANVMQQ LDNPYIVRMI GICEAESWML VMEMAELGPL NKYLQQNRHI KDKNIIELVH QVSMGMKYLE ESNFVHRDLA ARNVLLVTQH YAKISDFGLS KALRADENYY KAQTHGKWPV KWYAPECINY YKFSSKSDVW SFGVLMWEAF SYGQKPYRGM KGSEVTAMLE KGERMGCPAG CPREMYDLMN LCWTYDVENR PGFTAVELRL RNYYYDVVN
Genular Protein ID: 857843212
Symbol: Q6P1E0_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 629
- Mass: 71342
- Checksum: 75291D2AF1E346CC
- Sequence:
MAGSAVDSAN HLTYLFGNIT REEAEDYLVQ GGMTDGLYLL RQSRNYLGGF ALSVAHNRKA HHYTIERELN GTYAISGGRA HASPADLCHY HSQEPDGLIC LLKKPFNRPP GVQPKTGPFE DLKENLIREY VKQTWNLQGQ ALEQAIISQK PQLEKLIATT AHEKMPWFHG NISRDESEQT VLIGSKTNGK FLIRARDNSG SYALCLLHEG KVLHYRIDRD KTGKLSIPEG KKFDTLWQLV EHYSYKPDGL LRVLTVPCQK IGAQMGHPGS PNAHPVTWSP GGIISRIKSY SFPKPGHKKP APPQGSRPES TVSFNPYEPT GGPWGPDRGL QREALPMDTE VYESPYADPE EIRPKEVYLD RSLLTLEDNE LGSGNFGTVK KGYYQMKKVV KTVAVKILKN EANDPALKDE LLAEANVMQQ LDNPYIVRMI GICEAESWML VMEMAELGPL NKYLQQNRHI KDKNIIELVH QVSMGMKYLE ESNFVHRDLA ARNVLLVTQH YAKISDFGLS KALRADENYY KAQTHGKWPV KWYAPECINY YKFSSKSDVW SFGVLMWEAF SYGQKPYRGM KGSEVTAMLE KGERMGCPAG CPREMYDLMN LCWTYDVENR PGFTAVELRL RNYYYDVVN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.