Genular: Defining Cellular Identity and Function

Details for: Sdc1

Gene ID: 20969

Symbol: Sdc1

Ensembl ID: ENSMUSG00000020592

Description: syndecan 1

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-MMU-1971475)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Chondroitin sulfate/dermatan sulfate metabolism
(R-MMU-1793185)
Cytokine signaling in immune system
(R-MMU-1280215)
Extracellular matrix organization
(R-MMU-1474244)
Glycosaminoglycan metabolism
(R-MMU-1630316)
Hemostasis
(R-MMU-109582)
Heparan sulfate/heparin (hs-gag) metabolism
(R-MMU-1638091)
Hs-gag biosynthesis
(R-MMU-2022928)
Hs-gag degradation
(R-MMU-2024096)
Immune system
(R-MMU-168256)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Metabolism of fat-soluble vitamins
(R-MMU-6806667)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Non-integrin membrane-ecm interactions
(R-MMU-3000171)
Other interleukin signaling
(R-MMU-449836)
Retinoid metabolism and transport
(R-MMU-975634)
Sensory perception
(R-MMU-9709957)
Signaling by interleukins
(R-MMU-449147)
Syndecan interactions
(R-MMU-3000170)
Visual phototransduction
(R-MMU-2187338)
Canonical wnt signaling pathway
(GO:0060070)
Cargo receptor activity
(GO:0038024)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Golgi lumen
(GO:0005796)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Myoblast development
(GO:0048627)
Plasma membrane
(GO:0005886)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of extracellular exosome assembly
(GO:1903553)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Receptor-mediated endocytosis
(GO:0006898)

Other Information

Proteins

SDC1_MOUSE

Genular Protein ID: 2766739846

Symbol: SDC1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P18828 Q62278 Q9WVD2

Database IDs:

Citations:

PubMed ID: 2494194

Title: Molecular cloning of syndecan, an integral membrane proteoglycan.

PubMed ID: 2494194

DOI: 10.1083/jcb.108.4.1547

PubMed ID: 8349612

Title: Structural organization and genomic sequence of mouse syndecan-1 gene.

PubMed ID: 8349612

DOI: 10.1016/s0021-9258(19)85331-0

PubMed ID: 10373479

Title: Molecular polymorphism of the syndecans. Identification of a hypo-glycanated murine syndecan-1 splice variant.

PubMed ID: 10373479

DOI: 10.1074/jbc.274.26.18667

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8496192

Title: Organization and promoter activity of the mouse syndecan-1 gene.

PubMed ID: 8496192

DOI: 10.1016/s0021-9258(18)82143-3

PubMed ID: 8163535

Title: Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1.

PubMed ID: 8163535

DOI: 10.1016/s0021-9258(17)32716-3

PubMed ID: 8898217

Title: Msx1 controls inductive signaling in mammalian tooth morphogenesis.

PubMed ID: 8898217

DOI: 10.1242/dev.122.10.3035

PubMed ID: 10684261

Title: Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase.

PubMed ID: 10684261

DOI: 10.1083/jcb.148.4.811

PubMed ID: 16156648

Title: Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site.

PubMed ID: 16156648

DOI: 10.1021/bi050620i

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20361982

Title: The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.

PubMed ID: 20361982

DOI: 10.1016/j.jmb.2010.03.047

Sequence Information:

Length: 311
Mass: 32905
Checksum: 283FEC396FF40FCE
Sequence:

MRRAALWLWL CALALRLQPA LPQIVAVNVP PEDQDGSGDD SDNFSGSGTG ALPDTLSRQT 
PSTWKDVWLL TATPTAPEPT SSNTETAFTS VLPAGEKPEE GEPVLHVEAE PGFTARDKEK 
EVTTRPRETV QLPITQRAST VRVTTAQAAV TSHPHGGMQP GLHETSAPTA PGQPDHQPPR 
VEGGGTSVIK EVVEDGTANQ LPAGEGSGEQ DFTFETSGEN TAVAAVEPGL RNQPPVDEGA 
TGASQSLLDR KEVLGGVIAG GLVGLIFAVC LVAFMLYRMK KKDEGSYSLE EPKQANGGAY 
QKPTKQEEFY A

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sdc1

Associated with

Other Information

Molecular cloning of syndecan, an integral membrane proteoglycan. PubMed ID: 2494194

Structural organization and genomic sequence of mouse syndecan-1 gene. PubMed ID: 8349612

Molecular polymorphism of the syndecans. Identification of a hypo-glycanated murine syndecan-1 splice variant. PubMed ID: 10373479

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Organization and promoter activity of the mouse syndecan-1 gene. PubMed ID: 8496192

Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1. PubMed ID: 8163535

Msx1 controls inductive signaling in mammalian tooth morphogenesis. PubMed ID: 8898217

Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase. PubMed ID: 10684261

Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site. PubMed ID: 16156648

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. PubMed ID: 20361982