Genular: Defining Cellular Identity and Function

Details for: Syt1

Gene ID: 20979

Symbol: Syt1

Ensembl ID: ENSMUSG00000035864

Description: synaptotagmin I

Associated with

Acetylcholine neurotransmitter release cycle
(R-MMU-264642)
Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Dopamine neurotransmitter release cycle
(R-MMU-212676)
Gaba synthesis, release, reuptake and degradation
(R-MMU-888590)
Glutamate neurotransmitter release cycle
(R-MMU-210500)
Membrane trafficking
(R-MMU-199991)
Neuronal system
(R-MMU-112316)
Neurotransmitter release cycle
(R-MMU-112310)
Norepinephrine neurotransmitter release cycle
(R-MMU-181430)
Serotonin neurotransmitter release cycle
(R-MMU-181429)
Transmission across chemical synapses
(R-MMU-112315)
Vesicle-mediated transport
(R-MMU-5653656)
Axon
(GO:0030424)
Calcium-dependent activation of synaptic vesicle fusion
(GO:0099502)
Calcium-dependent phospholipid binding
(GO:0005544)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion-regulated exocytosis of neurotransmitter
(GO:0048791)
Calcium ion binding
(GO:0005509)
Calcium ion sensor activity
(GO:0061891)
Calmodulin binding
(GO:0005516)
Cell differentiation
(GO:0030154)
Cellular response to calcium ion
(GO:0071277)
Clathrin binding
(GO:0030276)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Dense core granule
(GO:0031045)
Detection of calcium ion
(GO:0005513)
Excitatory synapse
(GO:0060076)
Exocytic vesicle
(GO:0070382)
Fast, calcium ion-dependent exocytosis of neurotransmitter
(GO:0098746)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
Hippocampal mossy fiber to ca3 synapse
(GO:0098686)
Identical protein binding
(GO:0042802)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Neuron projection
(GO:0043005)
Neuron projection terminus
(GO:0044306)
Neurotransmitter secretion
(GO:0007269)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Phosphatidylserine binding
(GO:0001786)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of calcium ion-dependent exocytosis
(GO:0045956)
Positive regulation of calcium ion-dependent exocytosis of neurotransmitter
(GO:1903235)
Positive regulation of dendrite extension
(GO:1903861)
Positive regulation of dopamine secretion
(GO:0033603)
Positive regulation of synaptic transmission
(GO:0050806)
Positive regulation of vesicle fusion
(GO:0031340)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein heterooligomerization
(GO:0051291)
Regulation of calcium ion-dependent exocytosis
(GO:0017158)
Regulation of dopamine secretion
(GO:0014059)
Regulation of regulated secretory pathway
(GO:1903305)
Regulation of synaptic transmission, glutamatergic
(GO:0051966)
Regulation of synaptic vesicle exocytosis
(GO:2000300)
Response to calcium ion
(GO:0051592)
Secretory granule
(GO:0030141)
Snare binding
(GO:0000149)
Spontaneous neurotransmitter secretion
(GO:0061669)
Synapse
(GO:0045202)
Synaptic vesicle
(GO:0008021)
Synaptic vesicle endocytosis
(GO:0048488)
Synaptic vesicle exocytosis
(GO:0016079)
Synaptic vesicle membrane
(GO:0030672)
Synchronous neurotransmitter secretion
(GO:0071911)
Syntaxin-1 binding
(GO:0017075)
Syntaxin-3 binding
(GO:0030348)
Syntaxin binding
(GO:0019905)
Vesicle docking
(GO:0048278)

Other Information

Proteins

SYT1_MOUSE

Genular Protein ID: 285331103

Symbol: SYT1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P46096

Database IDs:

Citations:

PubMed ID: 7961887

Title: Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II.

PubMed ID: 7961887

DOI: 10.1016/s0021-9258(19)62031-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11242035

Title: Synaptotagmin I functions as a calcium regulator of release probability.

PubMed ID: 11242035

DOI: 10.1038/35065004

PubMed ID: 15466855

Title: SV2B regulates synaptotagmin 1 by direct interaction.

PubMed ID: 15466855

DOI: 10.1074/jbc.m407502200

PubMed ID: 17190793

Title: Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release.

PubMed ID: 17190793

DOI: 10.1083/jcb.200607021

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21496647

Title: Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.

PubMed ID: 21496647

DOI: 10.1016/j.cell.2011.03.034

PubMed ID: 23345244

Title: Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins.

PubMed ID: 23345244

DOI: 10.1523/jneurosci.4087-12.2013

PubMed ID: 27052163

Title: PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery.

PubMed ID: 27052163

DOI: 10.1016/j.celrep.2016.03.005

Sequence Information:

Length: 421
Mass: 47418
Checksum: 7FDEFF37170BD169
Sequence:

MVSASRPEAL AAPVTTVATL VPHNATEPAS PGEGKEDAFS KLKQKFMNEL HKIPLPPWAL 
IAIAIVAVLL VVTCCFCVCK KCLFKKKNKK KGKEKGGKNA INMKDVKDLG KTMKDQALKD 
DDAETGLTDG EEKEEPKEEE KLGKLQYSLD YDFQNNQLLV GIIQAAELPA LDMGGTSDPY 
VKVFLLPDKK KKFETKVHRK TLNPVFNEQF TFKVPYSELG GKTLVMAVYD FDRFSKHDII 
GEFKVPMNTV DFGHVTEEWR DLQSAEKEEQ EKLGDICFSL RYVPTAGKLT VVILEAKNLK 
KMDVGGLSDP YVKIHLMQNG KRLKKKKTTI KKNTLNPYYN ESFSFEVPFE QIQKVQVVVT 
VLDYDKIGKN DAIGKVFVGY NSTGAELRHW SDMLANPRRP IAQWHTLQVE EEVDAMLAVK 
K

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Syt1

Associated with

Other Information

Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II. PubMed ID: 7961887

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Synaptotagmin I functions as a calcium regulator of release probability. PubMed ID: 11242035

SV2B regulates synaptotagmin 1 by direct interaction. PubMed ID: 15466855

Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. PubMed ID: 17190793

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. PubMed ID: 21496647

Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins. PubMed ID: 23345244

PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery. PubMed ID: 27052163