Details for: ABCA3

Gene ID: 21

Symbol: ABCA3

Ensembl ID: ENSG00000167972

Description: ATP binding cassette subfamily A member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.5023
    Cell Significance Index: -22.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.1643
    Cell Significance Index: -21.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 48.7903
    Cell Significance Index: -23.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.1746
    Cell Significance Index: -17.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.3400
    Cell Significance Index: -17.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.8433
    Cell Significance Index: -22.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.9446
    Cell Significance Index: -21.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3179
    Cell Significance Index: -9.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0399
    Cell Significance Index: 409.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.0291
    Cell Significance Index: 44.4300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 1.7304
    Cell Significance Index: 21.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.5608
    Cell Significance Index: 44.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5047
    Cell Significance Index: 92.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1165
    Cell Significance Index: 400.4600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.0585
    Cell Significance Index: 14.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0061
    Cell Significance Index: 695.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8441
    Cell Significance Index: 10.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8247
    Cell Significance Index: 55.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8035
    Cell Significance Index: 35.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7539
    Cell Significance Index: 28.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7280
    Cell Significance Index: 12.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6296
    Cell Significance Index: 476.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6270
    Cell Significance Index: 38.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5783
    Cell Significance Index: 13.8700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.3071
    Cell Significance Index: 2.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2463
    Cell Significance Index: 222.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2106
    Cell Significance Index: 30.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1893
    Cell Significance Index: 18.7300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1782
    Cell Significance Index: 3.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1113
    Cell Significance Index: 18.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1112
    Cell Significance Index: 22.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0837
    Cell Significance Index: 9.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0832
    Cell Significance Index: 4.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0702
    Cell Significance Index: 13.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0557
    Cell Significance Index: 4.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0542
    Cell Significance Index: 34.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0455
    Cell Significance Index: 2.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0246
    Cell Significance Index: 37.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0225
    Cell Significance Index: 42.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0220
    Cell Significance Index: 29.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0213
    Cell Significance Index: 1.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0148
    Cell Significance Index: 27.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0009
    Cell Significance Index: 0.4700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0104
    Cell Significance Index: -4.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0153
    Cell Significance Index: -2.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0162
    Cell Significance Index: -0.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0176
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0223
    Cell Significance Index: -16.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0228
    Cell Significance Index: -16.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0232
    Cell Significance Index: -1.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0248
    Cell Significance Index: -1.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0267
    Cell Significance Index: -0.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0290
    Cell Significance Index: -16.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0298
    Cell Significance Index: -13.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0325
    Cell Significance Index: -5.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0413
    Cell Significance Index: -25.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0466
    Cell Significance Index: -0.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0604
    Cell Significance Index: -17.3900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0625
    Cell Significance Index: -0.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0660
    Cell Significance Index: -7.6900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0665
    Cell Significance Index: -0.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0752
    Cell Significance Index: -3.4100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1006
    Cell Significance Index: -1.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1032
    Cell Significance Index: -13.3300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1035
    Cell Significance Index: -1.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1081
    Cell Significance Index: -13.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1182
    Cell Significance Index: -2.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1182
    Cell Significance Index: -24.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1230
    Cell Significance Index: -2.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1247
    Cell Significance Index: -12.7400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1280
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1342
    Cell Significance Index: -15.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1344
    Cell Significance Index: -18.4600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1490
    Cell Significance Index: -0.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1582
    Cell Significance Index: -5.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1589
    Cell Significance Index: -5.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1808
    Cell Significance Index: -1.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1830
    Cell Significance Index: -5.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1882
    Cell Significance Index: -2.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1961
    Cell Significance Index: -20.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1981
    Cell Significance Index: -23.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2077
    Cell Significance Index: -26.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2151
    Cell Significance Index: -10.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2235
    Cell Significance Index: -6.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2249
    Cell Significance Index: -16.7600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2277
    Cell Significance Index: -4.9200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2570
    Cell Significance Index: -6.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2581
    Cell Significance Index: -20.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2646
    Cell Significance Index: -16.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2780
    Cell Significance Index: -6.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2843
    Cell Significance Index: -20.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2947
    Cell Significance Index: -15.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3069
    Cell Significance Index: -5.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3097
    Cell Significance Index: -6.6000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3300
    Cell Significance Index: -3.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3399
    Cell Significance Index: -7.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3402
    Cell Significance Index: -21.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3488
    Cell Significance Index: -12.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3883
    Cell Significance Index: -9.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transmembrane Transporter**: ABCA3 is a member of the ATP-binding cassette (ABC) transporter family, characterized by its ability to transport lipids and other molecules across the cell membrane. 2. **Surfactant Homeostasis**: ABCA3 plays a critical role in maintaining surfactant homeostasis in the lungs, which is essential for reducing surface tension and preventing alveolar collapse. 3. **Phospholipid Efflux**: ABCA3 is responsible for the efflux of phospholipids, such as phosphatidylcholine, from the cell membrane, which is essential for maintaining lipid homeostasis. 4. **Lung Development**: ABCA3 is also involved in lung development, particularly in the formation of lamellar bodies, which are essential for surfactant production and secretion. **Pathways and Functions** 1. **Abc-family Proteins Mediated Transport**: ABCA3 functions as a member of the ABC family of transporters, which are involved in the transport of lipids, steroids, and other molecules across the cell membrane. 2. **Lipid Homeostasis**: ABCA3 plays a critical role in maintaining lipid homeostasis in the lungs, which is essential for preventing lipid accumulation and promoting surfactant homeostasis. 3. **Surfactant Metabolism**: ABCA3 is involved in the metabolism of surfactant lipids, including phospholipid metabolism and phospholipid efflux. 4. **Xenobiotic Transport**: ABCA3 also functions as a xenobiotic transporter, responsible for the export of lipophilic compounds from the cell. **Clinical Significance** 1. **Surfactant Protein Deficiency (SPD)**: Mutations in the ABCA3 gene have been associated with SPD, a disease characterized by impaired surfactant production and secretion, leading to respiratory distress and impaired lung function. 2. **Pulmonary Alveolar Proteinosis (PAP)**: ABCA3 mutations have also been linked to PAP, a disease characterized by the accumulation of surfactant lipids in the lungs, leading to respiratory distress and impaired lung function. 3. **Lung Development Disorders**: Mutations in the ABCA3 gene can also disrupt lung development, leading to respiratory problems and impaired lung function. 4. **Cystic Fibrosis**: ABCA3 has also been implicated in cystic fibrosis, a genetic disorder characterized by impaired lung function and respiratory problems. In conclusion, the ABCA3 gene plays a critical role in maintaining lung function and surfactant homeostasis. Mutations in the ABCA3 gene have been associated with various lung diseases, including surfactant protein deficiency and pulmonary alveolar proteinosis. Further research is needed to fully understand the mechanisms underlying ABCA3 function and its role in lung disease.

Genular Protein ID: 4186138437

Symbol: ABCA3_HUMAN

Name: ABC-C transporter

UniProtKB Accession Codes:

Q99758 B2RU09 Q54A95 Q6P5P9 Q92473

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 26 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 12 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 1 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8706931

Title: Primary structure of a novel ABC transporter with a chromosomal localization on the band encoding the multidrug resistance-associated protein.

PubMed ID: 8706931

DOI: 10.1016/0014-5793(96)00700-4

PubMed ID: 9027511

Title: The cloning of a human ABC gene (ABC3) mapping to chromosome 16p13.3.

PubMed ID: 9027511

DOI: 10.1006/geno.1996.4500

PubMed ID: 11718719

Title: ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells.

PubMed ID: 11718719

DOI: 10.1016/s0014-5793(01)03056-3

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 16959783

Title: Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency.

PubMed ID: 16959783

DOI: 10.1074/jbc.m600071200

PubMed ID: 17574245

Title: ABCA3-mediated choline-phospholipids uptake into intracellular vesicles in A549 cells.

PubMed ID: 17574245

DOI: 10.1016/j.febslet.2007.05.078

PubMed ID: 20863830

Title: The surfactant lipid transporter ABCA3 is N-terminally cleaved inside LAMP3-positive vesicles.

PubMed ID: 20863830

DOI: 10.1016/j.febslet.2010.09.026

PubMed ID: 24142515

Title: Disruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3.

PubMed ID: 24142515

DOI: 10.1152/ajplung.00184.2013

PubMed ID: 25817392

Title: ABCA3 protects alveolar epithelial cells against free cholesterol induced cell death.

PubMed ID: 25817392

DOI: 10.1016/j.bbalip.2015.03.004

PubMed ID: 27352740

Title: Homooligomerization of ABCA3 and its functional significance.

PubMed ID: 27352740

DOI: 10.3892/ijmm.2016.2650

PubMed ID: 26903515

Title: Functional Validation of ABCA3 as a Miltefosine Transporter in Human Macrophages: IMPACT ON INTRACELLULAR SURVIVAL OF LEISHMANIA (VIANNIA) PANAMENSIS.

PubMed ID: 26903515

DOI: 10.1074/jbc.m115.688168

PubMed ID: 27031696

Title: Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases.

PubMed ID: 27031696

DOI: 10.1371/journal.pone.0152594

PubMed ID: 28887056

Title: Quantification of volume and lipid filling of intracellular vesicles carrying the ABCA3 transporter.

PubMed ID: 28887056

DOI: 10.1016/j.bbamcr.2017.08.013

PubMed ID: 31473345

Title: Metabolic labelling of choline phospholipids probes ABCA3 transport in lamellar bodies.

PubMed ID: 31473345

DOI: 10.1016/j.bbalip.2019.158516

PubMed ID: 15044640

Title: ABCA3 gene mutations in newborns with fatal surfactant deficiency.

PubMed ID: 15044640

DOI: 10.1056/nejmoa032178

PubMed ID: 15976379

Title: ABCA3 mutations associated with pediatric interstitial lung disease.

PubMed ID: 15976379

DOI: 10.1164/rccm.200503-504oc

PubMed ID: 16728712

Title: Alteration of the pulmonary surfactant system in full-term infants with hereditary ABCA3 deficiency.

PubMed ID: 16728712

DOI: 10.1164/rccm.200509-1535oc

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 25712598

Title: Respiratory failure in a term infant with cis and trans mutations in ABCA3.

PubMed ID: 25712598

DOI: 10.1038/jp.2014.236

PubMed ID: 27177387

Title: Tools to explore ABCA3 mutations causing interstitial lung disease.

PubMed ID: 27177387

DOI: 10.1002/ppul.23471

Sequence Information:

  • Length: 1704
  • Mass: 191362
  • Checksum: 606735C504839D0D
  • Sequence:
    • MAVLRQLALL LWKNYTLQKR KVLVTVLELF LPLLFSGILI WLRLKIQSEN VPNATIYPGQ 
SIQELPLFFT FPPPGDTWEL AYIPSHSDAA KTVTETVRRA LVINMRVRGF PSEKDFEDYI 
RYDNCSSSVL AAVVFEHPFN HSKEPLPLAV KYHLRFSYTR RNYMWTQTGS FFLKETEGWH 
TTSLFPLFPN PGPREPTSPD GGEPGYIREG FLAVQHAVDR AIMEYHADAA TRQLFQRLTV 
TIKRFPYPPF IADPFLVAIQ YQLPLLLLLS FTYTALTIAR AVVQEKERRL KEYMRMMGLS 
SWLHWSAWFL LFFLFLLIAA SFMTLLFCVK VKPNVAVLSR SDPSLVLAFL LCFAISTISF 
SFMVSTFFSK ANMAAAFGGF LYFFTYIPYF FVAPRYNWMT LSQKLCSCLL SNVAMAMGAQ 
LIGKFEAKGM GIQWRDLLSP VNVDDDFCFG QVLGMLLLDS VLYGLVTWYM EAVFPGQFGV 
PQPWYFFIMP SYWCGKPRAV AGKEEEDSDP EKALRNEYFE AEPEDLVAGI KIKHLSKVFR 
VGNKDRAAVR DLNLNLYEGQ ITVLLGHNGA GKTTTLSMLT GLFPPTSGRA YISGYEISQD 
MVQIRKSLGL CPQHDILFDN LTVAEHLYFY AQLKGLSRQK CPEEVKQMLH IIGLEDKWNS 
RSRFLSGGMR RKLSIGIALI AGSKVLILDE PTSGMDAISR RAIWDLLQRQ KSDRTIVLTT 
HFMDEADLLG DRIAIMAKGE LQCCGSSLFL KQKYGAGYHM TLVKEPHCNP EDISQLVHHH 
VPNATLESSA GAELSFILPR ESTHRFEGLF AKLEKKQKEL GIASFGASIT TMEEVFLRVG 
KLVDSSMDIQ AIQLPALQYQ HERRASDWAV DSNLCGAMDP SDGIGALIEE ERTAVKLNTG 
LALHCQQFWA MFLKKAAYSW REWKMVAAQV LVPLTCVTLA LLAINYSSEL FDDPMLRLTL 
GEYGRTVVPF SVPGTSQLGQ QLSEHLKDAL QAEGQEPREV LGDLEEFLIF RASVEGGGFN 
ERCLVAASFR DVGERTVVNA LFNNQAYHSP ATALAVVDNL LFKLLCGPHA SIVVSNFPQP 
RSALQAAKDQ FNEGRKGFDI ALNLLFAMAF LASTFSILAV SERAVQAKHV QFVSGVHVAS 
FWLSALLWDL ISFLIPSLLL LVVFKAFDVR AFTRDGHMAD TLLLLLLYGW AIIPLMYLMN 
FFFLGAATAY TRLTIFNILS GIATFLMVTI MRIPAVKLEE LSKTLDHVFL VLPNHCLGMA 
VSSFYENYET RRYCTSSEVA AHYCKKYNIQ YQENFYAWSA PGVGRFVASM AASGCAYLIL 
LFLIETNLLQ RLRGILCALR RRRTLTELYT RMPVLPEDQD VADERTRILA PSPDSLLHTP 
LIIKELSKVY EQRVPLLAVD RLSLAVQKGE CFGLLGFNGA GKTTTFKMLT GEESLTSGDA 
FVGGHRISSD VGKVRQRIGY CPQFDALLDH MTGREMLVMY ARLRGIPERH IGACVENTLR 
GLLLEPHANK LVRTYSGGNK RKLSTGIALI GEPAVIFLDE PSTGMDPVAR RLLWDTVARA 
RESGKAIIIT SHSMEECEAL CTRLAIMVQG QFKCLGSPQH LKSKFGSGYS LRAKVQSEGQ 
QEALEEFKAF VDLTFPGSVL EDEHQGMVHY HLPGRDLSWA KVFGILEKAK EKYGVDDYSV 
SQISLEQVFL SFAHLQPPTA EEGR

Genular Protein ID: 3319153392

Symbol: Q4LE27_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE27

Database IDs:

ARBA 7 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 PhylomeDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 1708
  • Mass: 191318
  • Checksum: E64C1D2ACEDA199B
  • Sequence:
    • TAPPPSPSLP LQDRAATSAH LALFTLSFQS TFLLFPAGCS AYLNLLRPPT SLAALGVPFS 
KTMAVLRQLA LLLWKNYTLQ KRKVLVTVLE LFLPLLFSGI LIWLRLKIQS ENVPNATIYP 
GQSIQELPLF FTFPPPGDTW ELAYIPSHSD AAKTVTETVR RALVINMRVR GFPSEKDFED 
YIRYDNCSSS VLAAVVFEHP FNHSKEPLPL AVKYHLRFSY TRRNYMWTQT GSFFLKETEG 
WHTTSLFPLF PNPGPREPTS PDGGEPGYIR EGFLAVQHAV DRAIMEYHAD AATRQLFQRL 
TVTIKRFPYP PFIADPFLVA IQYQLPLLLL LSFTYTALTI ARAVVQEKER RLKEYMRMMG 
LSSWLHWSAW FLLFFLFLLI AASFMTLLFC VKVKPNVAVL SRSDPSLVLA FLLCFAISTI 
SFSFMVSTFF SKGMGIQWRD LLSPVNVDDD FCFGQVLGML LLDSVLYGLV TWYMEAVFPG 
QFGVPQPWYF FIMPSYWCGK PRAVAGKEEE DSDPEKALRN EYFEAEPEDL VAGIKIKHLS 
KVFRVGNKDR AAVRDLNLNL YEGQITVLLG HNGAGKTTTL SMLTGLFPPT SGRAYISGYE 
ISQDMVQIRK SLGLCPQHDI LFDNLTVAEH LYFYAQLKGL SRQKCPEEVK QMLHIIGLED 
KWNSRSRFLS GGMRRKLSIG IALIAGSKVL ILDEPTSGMD AISRRAIWDL LQRQKSDRTI 
VLTTHFMDEA DLLGDRIAIM AKGELQCCGS SLFLKQKYGA GYHMTLVKEP HCNPEDISQL 
VHHHVPNATL ESSAGAELSF ILPRESTHRF EGLFAKLEKK QKELGIASFG ASITTMEEVF 
LRVGKLVDSS MDIQAIQLPA LQYQHERRAS DWAVDSNLCG AMDPSDGIGA LIEEERTAVK 
LNTGLALHCQ QFWAMFLKKA AYSWREWKMV AAQVLVPLTC VTLALLAINY SSELFDDPML 
RLTLGEYGRT VVPFSVPGTS QLGQQLSEHL KDALQAEGQE PREVLGDLEE FLIFRASVEG 
GGFNERCLVA ASFRDVGERT VVNALFNNQA YHSPATALAV VDNLLFKLLC GPHASIVVSN 
FPQPRSALQA AKDQFNEGRK GFDIALNLLF AMAFLASTFS ILAVSERAVQ AKHVQFVSGV 
HVASFWLSAL LWDLISFLIP SLLLLVVFKA FDVRAFTRDG HMADTLLLLL LYGWAIIPLM 
YLMNFFFLGA ATAYTRLTIF NILSGIATFL MVTIMRIPAV KLEELSKTLD HVFLVLPNHC 
LGMAVSSFYE NYETRRYCTS SEVAAHYCKK YNIQYQENFY AWSAPGVGRF VASMAASGCA 
YLILLFLIET NLLQRLRGIL CALRRRRTLT ELYTRMPVLP EDQDVADERT RILAPSPDSL 
LHTPLIIKEL SKVYEQRVPL LAVDRLSLAV QKGECFGLLG FNGAGKTTTF KMLTGEESLT 
SGDAFVGGHR ISSDVGKVRQ RIGYCPQFDA LLDHMTGREM LVMYARLRGI PERHIGACVE 
NTLRGLLLEP HANKLVRTYS GGNKRKLSTG IALIGEPAVI FLDEPSTGMD PVARRLLWDT 
VARARESGKA IIITSHSMEE CEALCTRLAI MVQGQFKCLG SPQHLKSKFG SGYSLRAKVQ 
SEGQQEALEE FKAFVDLTFP GSVLEDEHQG MVHYHLPGRD LSWAKVFGIL EKAKEKYGVD 
DYSVSQISLE QVFLSFAHLQ PPTAEEGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.