Details for: ABCA3

Gene ID: 21

Symbol: ABCA3

Ensembl ID: ENSG00000167972

Description: ATP binding cassette subfamily A member 3

Associated with

Cells (max top 100)

  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.18
    Marker Score: 20698
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.86
    Marker Score: 4599
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.58
    Marker Score: 41348
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.91
    Marker Score: 17937
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.87
    Marker Score: 69036
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.84
    Marker Score: 7492.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.79
    Marker Score: 109781
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.78
    Marker Score: 8213
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.77
    Marker Score: 18328
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.75
    Marker Score: 34847.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.74
    Marker Score: 58854.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.72
    Marker Score: 16377
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.72
    Marker Score: 65455
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.72
    Marker Score: 25756
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.69
    Marker Score: 6993.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.68
    Marker Score: 12875
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.65
    Marker Score: 14205
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.64
    Marker Score: 685
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.63
    Marker Score: 6319
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.49
    Marker Score: 2297
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169018
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.45
    Marker Score: 2431
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.31
    Marker Score: 27986
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.26
    Marker Score: 6586
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.25
    Marker Score: 342
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.25
    Marker Score: 1761
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.24
    Marker Score: 898.5
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.23
    Marker Score: 6591
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.18
    Marker Score: 528
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.11
    Marker Score: 3158
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.1
    Marker Score: 8325
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.07
    Marker Score: 681
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2161
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.03
    Marker Score: 2357
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48032
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1
    Marker Score: 655
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 666
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.94
    Marker Score: 4915
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14431
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5211
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.88
    Marker Score: 2954
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.88
    Marker Score: 1060
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.87
    Marker Score: 506
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.84
    Marker Score: 3515.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.82
    Marker Score: 261
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.81
    Marker Score: 1948
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 608.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.79
    Marker Score: 457
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.78
    Marker Score: 387
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.77
    Marker Score: 459
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.75
    Marker Score: 289
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.74
    Marker Score: 215
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 428
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.69
    Marker Score: 794
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.69
    Marker Score: 4144
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.69
    Marker Score: 1203
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.68
    Marker Score: 380
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.65
    Marker Score: 735
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 200
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.64
    Marker Score: 645
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 415
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.62
    Marker Score: 772
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.61
    Marker Score: 763.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.6
    Marker Score: 172
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 283
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.59
    Marker Score: 191
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 368
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.57
    Marker Score: 494
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.57
    Marker Score: 684
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.55
    Marker Score: 184
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.54
    Marker Score: 1267
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.54
    Marker Score: 2242
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.54
    Marker Score: 2250
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.54
    Marker Score: 492.5
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.51
    Marker Score: 169
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.49
    Marker Score: 148
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.46
    Marker Score: 234.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 205
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.46
    Marker Score: 1013
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.45
    Marker Score: 735
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.44
    Marker Score: 931
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.44
    Marker Score: 589
**Key characteristics:** - The ABCA3 protein is a type II transmembrane protein that is expressed in a variety of cell types. - It is a highly conserved protein, with a sequence similar to ABCA1 and ABCA4. - ABCA3 is a multi-pass membrane protein that is composed of eight transmembrane domains. - It is a member of the ATP-binding cassette family of proteins, which are involved in the transport of molecules between the cell and the extracellular environment. **Pathways and functions:** - ABCA3 is involved in a variety of cellular processes, including: - Abc-family proteins mediated transport - Abc-type xenobiotic transporter activity - Abc transporters in lipid homeostasis - Atpase-coupled transmembrane transporter activity - Atp binding - Atp hydrolysis activity - It is also involved in the metabolism of proteins, phosphatidylcholine flippase activity, and phospholipid transfer activity. **Clinical significance:** - Mutations in the ABCA3 gene have been linked to several human diseases, including: - Smdp3 disease - Diseases associated with surfactant metabolism - Diseases of metabolism - Disorders of transmembrane transporters - Lipid transporter activity - Metabolism of proteins

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.