Details for: ALAD

Gene ID: 210

Symbol: ALAD

Ensembl ID: ENSG00000148218

Description: aminolevulinate dehydratase

Associated with

Other Information

Genular Protein ID: 2248547344

Symbol: HEM2_HUMAN

Name: Delta-aminolevulinic acid dehydratase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3463993

Title: Human delta-aminolevulinate dehydratase: nucleotide sequence of a full-length cDNA clone.

PubMed ID: 3463993

DOI: 10.1073/pnas.83.20.7703

PubMed ID: 1678509

Title: RsaI polymorphism in the human delta-aminolevulinate dehydratase gene at 9q34.

PubMed ID: 1678509

DOI: 10.1093/nar/19.15.4307-a

PubMed ID: 1569184

Title: Cloning and expression of the defective genes from a patient with delta-aminolevulinate dehydratase porphyria.

PubMed ID: 1569184

DOI: 10.1172/jci115732

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 3092810

Title: Identification of lysine at the active site of human 5-aminolevulinate dehydratase.

PubMed ID: 3092810

DOI: 10.1042/bj2360447

PubMed ID: 1769358

Title: The delta-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes.

PubMed ID: 1769358

DOI: 10.1016/s0013-9351(05)80001-5

PubMed ID: 11032836

Title: The molecular mechanism of lead inhibition of human porphobilinogen synthase.

PubMed ID: 11032836

DOI: 10.1074/jbc.m007663200

PubMed ID: 17966070

Title: Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis.

PubMed ID: 17966070

DOI: 10.1080/15287390701550946

PubMed ID: 19812033

Title: Allosteric inhibition of human porphobilinogen synthase.

PubMed ID: 19812033

DOI: 10.1074/jbc.m109.026294

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12897770

Title: Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.

PubMed ID: 12897770

DOI: 10.1038/nsb963

PubMed ID: 1716854

Title: Molecular characterization of the human delta-aminolevulinate dehydratase 2 (ALAD2) allele: implications for molecular screening of individuals for genetic susceptibility to lead poisoning.

PubMed ID: 1716854

PubMed ID: 2063868

Title: Delta-aminolevulinate dehydratase deficient porphyria: identification of the molecular lesions in a severely affected homozygote.

PubMed ID: 2063868

PubMed ID: 1309003

Title: Cloning and expression of the defective genes in delta-aminolevulinate dehydratase porphyria: compound heterozygosity in this hereditary liver disease.

PubMed ID: 1309003

PubMed ID: 10519994

Title: A novel mutation of delta-aminolaevulinate dehydratase in a healthy child with 12% erythrocyte enzyme activity.

PubMed ID: 10519994

DOI: 10.1046/j.1365-2141.1999.01647.x

PubMed ID: 10706561

Title: Novel molecular defects of the delta-aminolevulinate dehydratase gene in a patient with inherited acute hepatic porphyria.

PubMed ID: 10706561

DOI: 10.1002/hep.510310321

PubMed ID: 16398658

Title: Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient.

PubMed ID: 16398658

DOI: 10.1111/j.1365-2141.2005.05852.x

PubMed ID: 17236137

Title: ALAD porphyria is a conformational disease.

PubMed ID: 17236137

DOI: 10.1086/511444

Sequence Information:

  • Length: 330
  • Mass: 36295
  • Checksum: E005F3055F6D9403
  • Sequence:
  • MQPQSVLHSG YFHPLLRAWQ TATTTLNASN LIYPIFVTDV PDDIQPITSL PGVARYGVKR 
    LEEMLRPLVE EGLRCVLIFG VPSRVPKDER GSAADSEESP AIEAIHLLRK TFPNLLVACD 
    VCLCPYTSHG HCGLLSENGA FRAEESRQRL AEVALAYAKA GCQVVAPSDM MDGRVEAIKE 
    ALMAHGLGNR VSVMSYSAKF ASCFYGPFRD AAKSSPAFGD RRCYQLPPGA RGLALRAVDR 
    DVREGADMLM VKPGMPYLDI VREVKDKHPD LPLAVYHVSG EFAMLWHGAQ AGAFDLKAAV 
    LEAMTAFRRA GADIIITYYT PQLLQWLKEE

Genular Protein ID: 523822687

Symbol: B7Z3I9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 313
  • Mass: 34520
  • Checksum: EA8A783C37E9C899
  • Sequence:
  • MQPQSVLHSG YFHPLLRAWQ TATTTLNASN LIYPIFVTYG VKRLEEMLRP LVEEGLRCVL 
    IFGVPSRVPK DERGSAADSE ESPAIEAIHL LRKTFPNLLV ACDVCLCPYT SHGHCGLLSE 
    NGAFRAEESR QRLAEVALAY AKAGCQVVAP SDMMDGRVEA IKEALMAHGL GNRVSVMSYS 
    AKFASCFYGP FRDAAKSSPA FGDRRCYQLP PGARGLALRA VDRDVREGAD MLMVKPGMPY 
    LDIVREVKDK HPDLPLAVYH VSGEFAMLWH GAQAGAFDLK AAVLEAMTAF RRAGADIIIT 
    YYTPQLLQWL KEE

Genular Protein ID: 53946838

Symbol: Q6ZMU0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 359
  • Mass: 39050
  • Checksum: 4AD5E8C53B11BAED
  • Sequence:
  • MPPTSSTPSL SRPGLGQAGK PDTGSHPPPT ISTSIFLSCF PTIPLSRPRT TGPSHSYQSI 
    SHPRSCRDVP DDIQPITSLP GVARYGVKRL EEMLRPLVEE GLRCVLIFGV PSRVPKDERG 
    SAADSEESPA IEAIHLLRKT FPNLLVACDV CLCPYTSHGH CGLLSENGAF RAEESRQRLA 
    EVALAYAKAG CQVVAPSDMM DGRVEAIKEA LMAHGLGNRV SVMSYSAKFA SCFYGPFRDA 
    AKSSPAFGDR RCYQLPPGAR GLALRAVDRD VREGADMLMV KPGMLYLDIV REVKDKHPDL 
    PLAVYHVSGE FAMLWHGAQA GAFDLKAAVL EAMTAFRRAG ADIIITYYTP QLLQWLKEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.