Details for: ALB

Gene ID: 213

Symbol: ALB

Ensembl ID: ENSG00000163631

Description: albumin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 25.3800
    Cell Significance Index: 427.5300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 21.7777
    Cell Significance Index: 58.3400
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 13.2180
    Cell Significance Index: 45.9900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 8.5852
    Cell Significance Index: 49.4400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 7.5797
    Cell Significance Index: 59.8400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 6.5264
    Cell Significance Index: 24.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 6.2419
    Cell Significance Index: 1238.7400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 5.7353
    Cell Significance Index: 92.2200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 4.5258
    Cell Significance Index: 66.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.7195
    Cell Significance Index: 635.1300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 2.9598
    Cell Significance Index: 42.4200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 2.1620
    Cell Significance Index: 21.3300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.7248
    Cell Significance Index: 4.5500
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.7012
    Cell Significance Index: 17.2700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.6363
    Cell Significance Index: 15.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3294
    Cell Significance Index: 99.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1745
    Cell Significance Index: 28.4500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.0439
    Cell Significance Index: 15.8600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9619
    Cell Significance Index: 5.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9298
    Cell Significance Index: 24.9200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.9154
    Cell Significance Index: 15.0900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.4857
    Cell Significance Index: 5.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4195
    Cell Significance Index: 47.8900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1284
    Cell Significance Index: 2.1600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.1203
    Cell Significance Index: 1.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1156
    Cell Significance Index: 13.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0344
    Cell Significance Index: 2.7300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0227
    Cell Significance Index: 0.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0124
    Cell Significance Index: 1.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0072
    Cell Significance Index: 2.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.6800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0019
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0016
    Cell Significance Index: 1.1500
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0005
    Cell Significance Index: -0.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0013
    Cell Significance Index: -0.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0022
    Cell Significance Index: -0.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0048
    Cell Significance Index: -2.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0079
    Cell Significance Index: -1.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0088
    Cell Significance Index: -5.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0119
    Cell Significance Index: -0.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0129
    Cell Significance Index: -0.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0168
    Cell Significance Index: -0.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0188
    Cell Significance Index: -2.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0198
    Cell Significance Index: -1.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0237
    Cell Significance Index: -3.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0239
    Cell Significance Index: -3.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0246
    Cell Significance Index: -0.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0265
    Cell Significance Index: -1.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0284
    Cell Significance Index: -2.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0286
    Cell Significance Index: -0.7400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0288
    Cell Significance Index: -0.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0331
    Cell Significance Index: -0.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0332
    Cell Significance Index: -5.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0377
    Cell Significance Index: -0.5400
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0446
    Cell Significance Index: -0.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0447
    Cell Significance Index: -2.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0486
    Cell Significance Index: -5.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0503
    Cell Significance Index: -3.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0516
    Cell Significance Index: -1.0800
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0553
    Cell Significance Index: -0.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0556
    Cell Significance Index: -3.1200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0619
    Cell Significance Index: -0.7900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0645
    Cell Significance Index: -0.6500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0659
    Cell Significance Index: -0.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0661
    Cell Significance Index: -6.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0682
    Cell Significance Index: -2.3900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0684
    Cell Significance Index: -0.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0716
    Cell Significance Index: -3.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0717
    Cell Significance Index: -1.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0733
    Cell Significance Index: -2.4000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0754
    Cell Significance Index: -1.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0754
    Cell Significance Index: -3.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0760
    Cell Significance Index: -2.4200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0765
    Cell Significance Index: -1.0000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0800
    Cell Significance Index: -1.1000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0823
    Cell Significance Index: -0.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0832
    Cell Significance Index: -5.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0835
    Cell Significance Index: -2.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0869
    Cell Significance Index: -4.0500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0882
    Cell Significance Index: -1.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0925
    Cell Significance Index: -2.6400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0945
    Cell Significance Index: -0.5000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0947
    Cell Significance Index: -1.2300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0962
    Cell Significance Index: -1.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0972
    Cell Significance Index: -2.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0988
    Cell Significance Index: -5.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0993
    Cell Significance Index: -1.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1031
    Cell Significance Index: -3.2600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1036
    Cell Significance Index: -2.5900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1043
    Cell Significance Index: -1.3100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1099
    Cell Significance Index: -0.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **High Abundance:** Albumin is the most abundant protein in the blood, making up approximately 60% of the total protein content. 2. **Multiple Binding Sites:** Albumin has multiple binding sites for various ligands, including hormones, drugs, and toxins. 3. **Water-Conserving Properties:** Albumin helps to regulate water balance in the body by binding and transporting water-soluble substances. 4. **Antioxidant Properties:** Albumin has antioxidant properties, helping to protect cells from oxidative damage. 5. **Scavenging Function:** Albumin can bind and remove toxins, such as bilirubin and heme, from the bloodstream. **Pathways and Functions:** 1. **Antioxidant Activity:** Albumin has antioxidant properties, protecting cells from oxidative damage. 2. **Binding and Uptake of Ligands:** Albumin binds and transports hormones, drugs, and toxins, regulating their levels and activity. 3. **Cellular Oxidant Detoxification:** Albumin helps to remove reactive oxygen species (ROS) from the bloodstream, protecting cells from oxidative damage. 4. **Cellular Response to Stimuli:** Albumin plays a role in regulating cellular responses to stimuli, such as inflammation and stress. 5. **Heme Biosynthesis and Degradation:** Albumin is involved in the regulation of heme biosynthesis and degradation, influencing iron homeostasis. 6. **Hormone Regulation:** Albumin binds and transports hormones, such as insulin-like growth factor (IGF), regulating their activity and transport. 7. **Toxin Removal:** Albumin binds and removes toxins, such as bilirubin and heme, from the bloodstream. **Clinical Significance:** 1. **Hemostasis:** Albumin plays a critical role in maintaining hemostasis, regulating blood clotting and preventing excessive bleeding. 2. **Liver Disease:** Albumin is often used as a marker of liver function, with low levels indicating liver disease or cirrhosis. 3. **Malnutrition:** Albumin is an important indicator of nutritional status, with low levels indicating malnutrition or malabsorption. 4. **Kidney Disease:** Albumin is involved in the regulation of kidney function, with low levels indicating kidney disease or impairment. 5. **Inflammation:** Albumin plays a role in regulating inflammatory responses, with altered levels indicating inflammation or infection. In conclusion, albumin is a multifaceted protein with diverse roles in maintaining physiological homeostasis and responding to various cellular stimuli. Its clinical significance extends to the diagnosis and management of various diseases, including liver disease, malnutrition, kidney disease, and inflammation. Further research is necessary to fully elucidate the mechanisms by which albumin regulates various physiological and pathological processes.

Genular Protein ID: 3504955921

Symbol: ALBU_HUMAN

Name: Albumin

UniProtKB Accession Codes:

P02768 E7ESS9 O95574 P04277 Q13140 Q645G4 Q68DN5 Q6UXK4 Q86YG0 Q8IUK7 Q9P157 Q9P1I7 Q9UHS3 Q9UJZ0

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 28 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 100 PDBsum 100 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 REPRODUCTION-2DPAGE 3 RNAct 1 Reactome 12 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6171778

Title: The sequence of human serum albumin cDNA and its expression in E. coli.

PubMed ID: 6171778

DOI: 10.1093/nar/9.22.6103

PubMed ID: 6275391

Title: Nucleotide sequence and the encoded amino acids of human serum albumin mRNA.

PubMed ID: 6275391

DOI: 10.1073/pnas.79.1.71

PubMed ID: 3009475

Title: Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4.

PubMed ID: 3009475

DOI: 10.1016/s0021-9258(19)62680-3

PubMed ID: 11483580

Title: Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.

PubMed ID: 11483580

DOI: 10.1101/gr.175501

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 2419329

Title: The human albumin gene. Characterization of the 5' and 3' flanking regions and the polymorphic gene transcripts.

PubMed ID: 2419329

DOI: 10.1016/s0021-9258(17)35775-7

PubMed ID: 1225573

Title: Complete amino acid sequence of human serum albumin.

PubMed ID: 1225573

DOI: 10.1016/0014-5793(75)80242-0

PubMed ID: 7895732

Title: The human myocardial two-dimensional gel protein database: update 1994.

PubMed ID: 7895732

DOI: 10.1002/elps.11501501209

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 3087352

Title: The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin.

PubMed ID: 3087352

DOI: 10.1016/0006-291x(86)90429-8

PubMed ID: 2437111

Title: Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s).

PubMed ID: 2437111

DOI: 10.1016/s0021-9258(18)45523-8

PubMed ID: 955075

Title: Lysine residue 199 of human serum albumin is modified by acetylsalicylic acid.

PubMed ID: 955075

DOI: 10.1016/0014-5793(76)80496-6

PubMed ID: 15047055

Title: Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides.

PubMed ID: 15047055

DOI: 10.1016/j.jasms.2003.11.014

PubMed ID: 656055

Title: Lysine residue 240 of human serum albumin is involved in high-affinity binding of bilirubin.

PubMed ID: 656055

DOI: 10.1042/bj1710453

PubMed ID: 6853480

Title: The principal site of nonenzymatic glycosylation of human serum albumin in vivo.

PubMed ID: 6853480

DOI: 10.1016/s0021-9258(18)32384-6

PubMed ID: 6234017

Title: Effect of serum albumin on siderophore-mediated utilization of transferrin iron.

PubMed ID: 6234017

DOI: 10.1021/bi00305a003

PubMed ID: 6706980

Title: Nonenzymatic glycosylation of human serum albumin alters its conformation and function.

PubMed ID: 6706980

DOI: 10.1016/s0021-9258(17)43168-1

PubMed ID: 3759977

Title: Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites.

PubMed ID: 3759977

DOI: 10.1016/s0021-9258(18)67052-8

PubMed ID: 8134387

Title: A nucleotide insertion and frameshift cause analbuminemia in an Italian family.

PubMed ID: 8134387

DOI: 10.1073/pnas.91.6.2275

PubMed ID: 9183005

Title: Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma.

PubMed ID: 9183005

DOI: 10.1111/j.1432-1033.1997.00676.x

PubMed ID: 19021548

Title: Albumin as a zinc carrier: properties of its high-affinity zinc-binding site.

PubMed ID: 19021548

DOI: 10.1042/bst0361317

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28330995

Title: Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.

PubMed ID: 28330995

DOI: 10.1073/pnas.1618291114

PubMed ID: 2727704

Title: Three-dimensional structure of human serum albumin.

PubMed ID: 2727704

DOI: 10.1126/science.2727704

PubMed ID: 2374930

Title: Structure of human serum albumin.

PubMed ID: 2374930

DOI: 10.1126/science.2374930

PubMed ID: 1630489

Title: Atomic structure and chemistry of human serum albumin.

PubMed ID: 1630489

DOI: 10.1038/358209a0

PubMed ID: 9731778

Title: Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites.

PubMed ID: 9731778

DOI: 10.1038/1869

PubMed ID: 10388840

Title: Crystal structure of human serum albumin at 2.5-A resolution.

PubMed ID: 10388840

DOI: 10.1093/protein/12.6.439

PubMed ID: 10940303

Title: Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures.

PubMed ID: 10940303

DOI: 10.1074/jbc.m005460200

PubMed ID: 11743713

Title: Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids.

PubMed ID: 11743713

DOI: 10.1006/jmbi.2000.5208

PubMed ID: 28567254

Title: Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins.

PubMed ID: 28567254

DOI: 10.1039/c6sc02267g

PubMed ID: 3828358

Title: Albumin Canterbury (313 Lys-->Asn). A point mutation in the second domain of serum albumin.

PubMed ID: 3828358

DOI: 10.1016/0167-4838(87)90088-4

PubMed ID: 3474609

Title: Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning.

PubMed ID: 3474609

DOI: 10.1073/pnas.84.13.4413

PubMed ID: 3479777

Title: Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations.

PubMed ID: 3479777

DOI: 10.1073/pnas.84.22.8001

PubMed ID: 2911589

Title: Identical structural changes in inherited albumin variants from different populations.

PubMed ID: 2911589

DOI: 10.1073/pnas.86.2.434

PubMed ID: 2762316

Title: Point substitutions in Japanese alloalbumins.

PubMed ID: 2762316

DOI: 10.1073/pnas.86.16.6092

PubMed ID: 2404284

Title: Point substitutions in albumin genetic variants from Asia.

PubMed ID: 2404284

DOI: 10.1073/pnas.87.1.497

PubMed ID: 2104980

Title: Albumin Redhill (-1 Arg, 320 Ala-->Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site.

PubMed ID: 2104980

DOI: 10.1073/pnas.87.1.26

PubMed ID: 2247440

Title: Mutations in genetic variants of human serum albumin found in Italy.

PubMed ID: 2247440

DOI: 10.1073/pnas.87.22.8721

PubMed ID: 2068071

Title: A donor splice mutation and a single-base deletion produce two carboxyl-terminal variants of human serum albumin.

PubMed ID: 2068071

DOI: 10.1073/pnas.88.14.5959

PubMed ID: 1946412

Title: Genetic variants of serum albumin in Americans and Japanese.

PubMed ID: 1946412

DOI: 10.1073/pnas.88.21.9853

PubMed ID: 1859851

Title: Structural characterization of a glycoprotein variant of human serum albumin: albumin Casebrook (494 Asp-->Asn).

PubMed ID: 1859851

DOI: 10.1016/0925-4439(91)90023-3

PubMed ID: 1347703

Title: Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions.

PubMed ID: 1347703

DOI: 10.1016/0167-4838(92)90207-t

PubMed ID: 1518850

Title: Alloalbuminemia in Sweden: structural study and phenotypic distribution of nine albumin variants.

PubMed ID: 1518850

DOI: 10.1073/pnas.89.17.8225

PubMed ID: 8513793

Title: The structural characterization and bilirubin-binding properties of albumin Herborn, a [Lys240-->Glu] albumin mutant.

PubMed ID: 8513793

DOI: 10.1111/j.1432-1033.1993.tb17939.x

PubMed ID: 8347685

Title: Albumin Hawkes Bay; a low level variant caused by loss of a sulphydryl group at position 177.

PubMed ID: 8347685

DOI: 10.1016/0925-4439(93)90151-p

PubMed ID: 7902134

Title: Protein and DNA sequence analysis of a 'private' genetic variant: albumin Ortonovo (Glu-505-->Lys).

PubMed ID: 7902134

DOI: 10.1016/0925-4439(93)90117-j

PubMed ID: 8022807

Title: Genetic variants of human serum albumin in Italy: point mutants and a carboxyl-terminal variant.

PubMed ID: 8022807

DOI: 10.1073/pnas.91.14.6476

PubMed ID: 8048949

Title: An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families.

PubMed ID: 8048949

DOI: 10.1006/bbrc.1994.1998

PubMed ID: 7852505

Title: Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia.

PubMed ID: 7852505

DOI: 10.1210/jcem.80.2.7852505

PubMed ID: 9329347

Title: A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred.

PubMed ID: 9329347

DOI: 10.1210/jcem.82.10.4276

PubMed ID: 9589637

Title: Familial dysalbuminemic hypertriiodothyroninemia: a new, dominantly inherited albumin defect.

PubMed ID: 9589637

DOI: 10.1210/jcem.83.5.4815

PubMed ID: 11680902

Title: Towards defining the urinary proteome using liquid chromatography-tandem mass spectrometry I. Profiling an unfractionated tryptic digest.

PubMed ID: 11680902

DOI: 10.1002/1615-9861(200101)1:1<93::aid-prot93>3.0.co;2-3

PubMed ID: 11168369

Title: A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges.

PubMed ID: 11168369

DOI: 10.1046/j.1432-1033.2001.01899.x

Sequence Information:

  • Length: 609
  • Mass: 69367
  • Checksum: F88FF61DD242E818
  • Sequence:
    • MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA FAQYLQQCPF 
EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT VATLRETYGE MADCCAKQEP 
ERNECFLQHK DDNPNLPRLV RPEVDVMCTA FHDNEETFLK KYLYEIARRH PYFYAPELLF 
FAKRYKAAFT ECCQAADKAA CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV 
ARLSQRFPKA EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK 
ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF LGMFLYEYAR 
RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE FKPLVEEPQN LIKQNCELFE 
QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV 
LNQLCVLHEK TPVSDRVTKC CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL 
SEKERQIKKQ TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV 
AASQAALGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.