Genular: Defining Cellular Identity and Function

Details for: Tal1

Gene ID: 21349

Symbol: Tal1

Ensembl ID: ENSMUSG00000028717

Description: T cell acute lymphocytic leukemia 1

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-MMU-8939236)
Transcriptional regulation by runx1
(R-MMU-8878171)
Angiogenesis
(GO:0001525)
Astrocyte fate commitment
(GO:0060018)
Cell differentiation
(GO:0030154)
Cell fate commitment
(GO:0045165)
Central nervous system neuron differentiation
(GO:0021953)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Definitive hemopoiesis
(GO:0060216)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Embryonic hemopoiesis
(GO:0035162)
Enzyme binding
(GO:0019899)
Erythrocyte differentiation
(GO:0030218)
Erythrocyte maturation
(GO:0043249)
Generation of neurons
(GO:0048699)
Hemangioblast cell differentiation
(GO:0060217)
Hematopoietic stem cell differentiation
(GO:0060218)
Hemopoiesis
(GO:0030097)
Histone deacetylase binding
(GO:0042826)
Locomotory behavior
(GO:0007626)
Megakaryocyte development
(GO:0035855)
Megakaryocyte differentiation
(GO:0030219)
Multicellular organism development
(GO:0007275)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Platelet formation
(GO:0030220)
Positive regulation of cell division
(GO:0051781)
Positive regulation of chromatin organization
(GO:1905269)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of mitotic cell cycle
(GO:0045931)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of cell population proliferation
(GO:0042127)
Regulation of mast cell differentiation
(GO:0060375)
Regulation of myeloid cell differentiation
(GO:0045637)
Regulation of somatic stem cell population maintenance
(GO:1904672)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Spinal cord association neuron differentiation
(GO:0021527)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

T-cell acute lymphocytic leukemia protein 1 homolog

Genular Protein ID: 2566448086

Symbol: TAL1_MOUSE

Name: T-cell acute lymphocytic leukemia protein 1 homolog

UniProtKB Accession Codes:

P22091

Database IDs:

Citations:

PubMed ID: 1704135

Title: Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL.

PubMed ID: 1704135

DOI: 10.1073/pnas.88.3.869

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9391090

Title: The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.

PubMed ID: 9391090

DOI: 10.1073/pnas.94.25.13707

PubMed ID: 11904294

Title: Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells.

PubMed ID: 11904294

DOI: 10.1074/jbc.m109812200

PubMed ID: 16407974

Title: ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.

PubMed ID: 16407974

DOI: 10.1038/sj.emboj.7600934

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23980096

Title: Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.

PubMed ID: 23980096

DOI: 10.1084/jem.20130512

Sequence Information:

Length: 329
Mass: 34279
Checksum: 189480B6B93CB371
Sequence:

MTERPPSEAA RSDPQLEGQD AAEARMAPPH LVLLNGVAKE TSRAAPAEPP VIELGARSGA 
GGGPASGGGA ARDLKGRDAV AAEARLRVPT TELCRPPGPA PAPAPASAPA ELPGDGRMVQ 
LSPPALAAPA GPGRALLYSL SQPLASLGSG FFGEPDAFPM FTNNNRVKRR PSPYEMEISD 
GPHTKVVRRI FTNSRERWRQ QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA 
KLLNDQEEEG TQRAKPGKDP VVGAGGGGAG GGIPPEDLLQ DVLSPNSSCG SSLDGAASPD 
SYTEEPTPKH TSRSLHPALL PAADGAGPR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tal1

Associated with

Other Information

Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL. PubMed ID: 1704135

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. PubMed ID: 9391090

Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells. PubMed ID: 11904294

ETO2 coordinates cellular proliferation and differentiation during erythropoiesis. PubMed ID: 16407974

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. PubMed ID: 23980096