Genular: Defining Cellular Identity and Function

Details for: Tap2

Gene ID: 21355

Symbol: Tap2

Ensembl ID: ENSMUSG00000024339

Description: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-MMU-983170)
Antigen processing-cross presentation
(R-MMU-1236975)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Er-phagosome pathway
(R-MMU-1236974)
Immune system
(R-MMU-168256)
Abc-type peptide antigen transporter activity
(GO:0015433)
Abc-type peptide transporter activity
(GO:0015440)
Abc-type transporter activity
(GO:0140359)
Adaptive immune response
(GO:0002250)
Adp binding
(GO:0043531)
Antigen processing and presentation of endogenous peptide antigen via mhc class i
(GO:0019885)
Antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway, tap-dependent
(GO:0002489)
Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-dependent
(GO:0002485)
Antigen processing and presentation of exogenous protein antigen via mhc class ib, tap-dependent
(GO:0002481)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cytosol to endoplasmic reticulum transport
(GO:0046967)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mhc class ib protein binding
(GO:0023029)
Mhc class i peptide loading complex
(GO:0042824)
Mhc class i protein binding
(GO:0042288)
Mhc protein binding
(GO:0042287)
Nuclear speck
(GO:0016607)
Nucleotide binding
(GO:0000166)
Peptide antigen binding
(GO:0042605)
Peptide antigen transport
(GO:0046968)
Peptide transmembrane transporter activity
(GO:1904680)
Peptide transport
(GO:0015833)
Positive regulation of antigen processing and presentation of peptide antigen via mhc class i
(GO:0002591)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Protection from natural killer cell mediated cytotoxicity
(GO:0042270)
Protein-containing complex assembly
(GO:0065003)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein transport
(GO:0015031)
Response to molecule of bacterial origin
(GO:0002237)
Tap1 binding
(GO:0046978)
Tap2 binding
(GO:0046979)
Tapasin binding
(GO:0046980)
Tap complex
(GO:0042825)
T cell mediated cytotoxicity
(GO:0001913)
Transmembrane transport
(GO:0055085)

Other Information

Proteins

Antigen peptide transporter 2

Genular Protein ID: 4077007802

Symbol: TAP2_MOUSE

Name: Antigen peptide transporter 2

UniProtKB Accession Codes:

P36371

Database IDs:

Citations:

PubMed ID: 1339432

Title: Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules.

PubMed ID: 1339432

DOI: 10.1016/s0021-9258(19)49745-7

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 702
Mass: 77445
Checksum: F93DFA38B057AC0A
Sequence:

MALSYLRPWV SLLLADMALL GLLQGSLGNL LPQGLPGLWI EGTLRLGVLW GLLKVGELLG 
LVGTLLPLLC LATPLFFSLR ALVGGTASTS VVRVASASWG WLLAGYGAVA LSWAVWAVLS 
PAGVQEKEPG QENRTLMKRL LKLSRPDLPF LIAAFFFLVV AVWGETLIPR YSGRVIDILG 
GDFDPDAFAS AIFFMCLFSV GSSFSAGCRG GSFLFTMSRI NLRIREQLFS SLLRQDLGFF 
QETKTGELNS RLSSDTSLMS RWLPFNANIL LRSLVKVVGL YFFMLQVSPR LTFLSLLDLP 
LTIAAEKVYN PRHQAVLKEI QDAVAKAGQV VREAVGGLQT VRSFGAEEQE VSHYKEALER 
CRQLWWRRDL EKDVYLVIRR VMALGMQVLI LNCGVQQILA GEVTRGGLLS FLLYQEEVGQ 
YVRNLVYMYG DMLSNVGAAE KVFSYLDRKP NLPQPGILAP PWLEGRVEFQ DVSFSYPRRP 
EKPVLQGLTF TLHPGTVTAL VGPNGSGKST VAALLQNLYQ PTGGQLLLDG EPLTEYDHHY 
LHRQVVLVGQ EPVLFSGSVK DNIAYGLRDC EDAQVMAAAQ AACADDFIGE MTNGINTEIG 
EKGGQLAVGQ KQRLAIARAL VRNPRVLILD EATSALDAQC EQALQNWRSQ GDRTMLVIAH 
RLHTVQNADQ VLVLKQGRLV EHDQLRDGQD VYAHLVQQRL EA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.