Genular: Defining Cellular Identity and Function

Details for: Slc6a6

Gene ID: 21366

Symbol: Slc6a6

Ensembl ID: ENSMUSG00000030096

Description: solute carrier family 6 (neurotransmitter transporter, taurine), member 6

Associated with

Amino acid transport across the plasma membrane
(R-MMU-352230)
Na+/cl- dependent neurotransmitter transporters
(R-MMU-442660)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-MMU-425366)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-MMU-425393)
Transport of small molecules
(R-MMU-382551)
Alanine transmembrane transporter activity
(GO:0022858)
Alanine transport
(GO:0032328)
Amino acid:sodium symporter activity
(GO:0005283)
Amino acid import across plasma membrane
(GO:0089718)
Amino acid transmembrane transporter activity
(GO:0015171)
Amino acid transport
(GO:0006865)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Beta-alanine transmembrane transporter activity
(GO:0001761)
Beta-alanine transport
(GO:0001762)
Cell projection
(GO:0042995)
Dendrite
(GO:0030425)
Gaba-ergic synapse
(GO:0098982)
Gamma-aminobutyric acid:sodium:chloride symporter activity
(GO:0005332)
Gamma-aminobutyric acid import
(GO:0051939)
Gamma-aminobutyric acid transmembrane transporter activity
(GO:0015185)
Import across plasma membrane
(GO:0098739)
Membrane
(GO:0016020)
Microvillus membrane
(GO:0031528)
Modulation of chemical synaptic transmission
(GO:0050804)
Neuronal cell body
(GO:0043025)
Neurotransmitter transport
(GO:0006836)
Nitrogen compound transport
(GO:0071705)
Plasma membrane
(GO:0005886)
Plasma membrane protein complex
(GO:0098797)
Positive regulation of cell differentiation
(GO:0045597)
Postsynaptic membrane
(GO:0045211)
Sodium ion transmembrane transport
(GO:0035725)
Symporter activity
(GO:0015293)
Taurine:sodium symporter activity
(GO:0005369)
Taurine binding
(GO:0030977)
Taurine transmembrane transporter activity
(GO:0005368)
Taurine transport
(GO:0015734)

Other Information

Proteins

Sodium- and chloride-dependent taurine transporter

Genular Protein ID: 863457544

Symbol: SC6A6_MOUSE

Name: Sodium- and chloride-dependent taurine transporter

UniProtKB Accession Codes:

O35316 P31642 Q91WI2

Database IDs:

Citations:

PubMed ID: 1465453

Title: Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain.

PubMed ID: 1465453

DOI: 10.1073/pnas.89.24.12145

PubMed ID: 9375654

Title: Molecular characterization and in situ localization of a mouse retinal taurine transporter.

PubMed ID: 9375654

DOI: 10.1046/j.1471-4159.1997.69062238.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22896705

Title: Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents.

PubMed ID: 22896705

DOI: 10.1074/jbc.m112.368175

PubMed ID: 30270321

Title: Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6.

PubMed ID: 30270321

DOI: 10.1248/bpb.b18-00168

Sequence Information:

Length: 621
Mass: 69856
Checksum: 4D3E4ACFDB7D7EA2
Sequence:

MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEADGKPPQ REKWSSKIDF VLSVAGGFVG 
LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEVI IGQYTSEGGI TCWEKICPLF 
SGIGYASIVI VSLLNVYYIV ILAWATYYLF HSFQKDLPWA HCNHSWNTPQ CMEDTLRRNE 
SHWVSLSTAN FTSPVIEFWE RNVLSLSSGI DNPGSLKWDL ALCLLLVWLV CFFCIWKGVR 
STGKVVYFTA TFPFAMLLVL LVRGLTLPGA GEGIKFYLYP DISRLGDPQV WIDAGTQIFF 
SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF MAQEQGVDIA 
DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL DSQFVEVEGQ ITSLVDLYPS 
FLRKGYRREI FIAILCSISY LLGLTMVTEG GMYVFQLFDY YAASGVCLLW VAFFECFVIA 
WIYGGDNLYD GIEDMIGYRP GPWMKYSWAV ITPALCVGCF VFSLVKYVPL TYNKVYRYPD 
WAIGLGWGLA LSSMLCIPLV IVILLCRTEG PLRVRIKYLI TPREPNRWAV EREGATPFHS 
RVTLMNGALM KPSHVIVETM M

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc6a6

Associated with

Other Information

Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain. PubMed ID: 1465453

Molecular characterization and in situ localization of a mouse retinal taurine transporter. PubMed ID: 9375654

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. PubMed ID: 22896705