Genular: Defining Cellular Identity and Function

Details for: Tbp

Gene ID: 21374

Symbol: Tbp

Ensembl ID: ENSMUSG00000014767

Description: TATA box binding protein

Associated with

B-wich complex positively regulates rrna expression
(R-MMU-5250924)
Epigenetic regulation of gene expression
(R-MMU-212165)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Positive epigenetic regulation of rrna expression
(R-MMU-5250913)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rna polymerase iii transcription
(R-MMU-74158)
Rna polymerase iii transcription initiation
(R-MMU-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-MMU-76061)
Rna polymerase iii transcription initiation from type 2 promoter
(R-MMU-76066)
Rna polymerase iii transcription initiation from type 3 promoter
(R-MMU-76071)
Rna polymerase ii pre-transcription events
(R-MMU-674695)
Rna polymerase ii promoter escape
(R-MMU-73776)
Rna polymerase ii transcribes snrna genes
(R-MMU-6807505)
Rna polymerase ii transcription
(R-MMU-73857)
Rna polymerase ii transcription initiation
(R-MMU-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-MMU-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-MMU-73779)
Rna polymerase i promoter clearance
(R-MMU-73854)
Rna polymerase i promoter escape
(R-MMU-73772)
Rna polymerase i transcription
(R-MMU-73864)
Rna polymerase i transcription initiation
(R-MMU-73762)
Rna polymerase i transcription termination
(R-MMU-73863)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by tp53
(R-MMU-3700989)
Aryl hydrocarbon receptor binding
(GO:0017162)
Chromatin
(GO:0000785)
Core promoter sequence-specific dna binding
(GO:0001046)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor binding
(GO:0140297)
Dna-templated transcription initiation
(GO:0006352)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Euchromatin
(GO:0000791)
Female germ cell nucleus
(GO:0001674)
Female pronucleus
(GO:0001939)
Male germ cell nucleus
(GO:0001673)
Male pronucleus
(GO:0001940)
Mrna transcription by rna polymerase ii
(GO:0042789)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Pronucleus
(GO:0045120)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Rna polymerase ii general transcription initiation factor activity
(GO:0016251)
Rna polymerase ii general transcription initiation factor binding
(GO:0001091)
Rna polymerase iii general transcription initiation factor activity
(GO:0000995)
Rna polymerase ii preinitiation complex assembly
(GO:0051123)
Rna polymerase i transcription regulator complex
(GO:0000120)
Rna polymerase transcription factor sl1 complex
(GO:0005668)
Tfiib-class transcription factor binding
(GO:0001093)
Transcription by rna polymerase ii
(GO:0006366)
Transcription by rna polymerase iii
(GO:0006383)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription factor tfiia complex
(GO:0005672)
Transcription factor tfiid complex
(GO:0005669)

Other Information

Proteins

TATA-box-binding protein

Genular Protein ID: 4280494951

Symbol: TBP_MOUSE

Name: TATA-box-binding protein

UniProtKB Accession Codes:

P29037 O09169 Q80UL8 Q8C3S1

Database IDs:

Citations:

PubMed ID: 1861978

Title: Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID).

PubMed ID: 1861978

DOI: 10.1093/nar/19.14.3861

PubMed ID: 8332475

Title: Structure of a mammalian TBP (TATA-binding protein) gene: isolation of the mouse TBP genome.

PubMed ID: 8332475

DOI: 10.1093/nar/21.11.2769

PubMed ID: 9286694

Title: Linkage of TATA-binding protein and proteasome subunit C5 genes in mice and humans reveals synteny conserved between mammals and invertebrates.

PubMed ID: 9286694

DOI: 10.1006/geno.1997.4839

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 16412700

Title: Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice.

PubMed ID: 16412700

DOI: 10.1016/j.modgep.2005.09.005

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8769130

Title: Promoter structure of the mouse TATA-binding protein (TBP) gene.

PubMed ID: 8769130

DOI: 10.1006/bbrc.1996.1166

PubMed ID: 9050847

Title: Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1.

PubMed ID: 9050847

DOI: 10.1073/pnas.94.5.1733

PubMed ID: 9524124

Title: UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells.

PubMed ID: 9524124

DOI: 10.1093/emboj/17.7.2019

PubMed ID: 10215616

Title: Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300).

PubMed ID: 10215616

DOI: 10.1042/bj3390751

PubMed ID: 10593900

Title: MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression.

PubMed ID: 10593900

DOI: 10.1074/jbc.274.51.36159

PubMed ID: 14612417

Title: The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription.

PubMed ID: 14612417

DOI: 10.1128/mcb.23.23.8773-8785.2003

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26961175

Title: A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission.

PubMed ID: 26961175

DOI: 10.1038/srep22892

Sequence Information:

Length: 316
Mass: 34709
Checksum: A33D776160B4A393
Sequence:

MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ 
QQQQQQQQQQ AVATAAASVQ QSTSQQPTQG ASGQTPQLFH SQTLTTAPLP GTTPLYPSPM 
TPMTPITPAT PASESSGIVP QLQNIVSTVN LGCKLDLKTI ALRARNAEYN PKRFAAVIMR 
IREPRTTALI FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPAKFLDF KIQNMVGSCD 
VKFPIRLEGL VLTHQQFSSY EPELFPGLIY RMIKPRIVLL IFVSGKVVLT GAKVRAEIYE 
AFENIYPILK GFRKTT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tbp

Associated with

Other Information

Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID). PubMed ID: 1861978

Structure of a mammalian TBP (TATA-binding protein) gene: isolation of the mouse TBP genome. PubMed ID: 8332475

Linkage of TATA-binding protein and proteasome subunit C5 genes in mice and humans reveals synteny conserved between mammals and invertebrates. PubMed ID: 9286694

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice. PubMed ID: 16412700

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Promoter structure of the mouse TATA-binding protein (TBP) gene. PubMed ID: 8769130

Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1. PubMed ID: 9050847

UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. PubMed ID: 9524124

Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300). PubMed ID: 10215616

MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. PubMed ID: 10593900

The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. PubMed ID: 14612417

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission. PubMed ID: 26961175