Genular: Defining Cellular Identity and Function

Details for: Tbx2

Gene ID: 21385

Symbol: Tbx2

Ensembl ID: ENSMUSG00000000093

Description: T-box 2

Associated with

Aorta morphogenesis
(GO:0035909)
Apoptotic process
(GO:0006915)
Atrioventricular canal development
(GO:0036302)
Atrioventricular canal morphogenesis
(GO:1905222)
Cardiac jelly development
(GO:1905072)
Cardiac muscle cell myoblast differentiation
(GO:0060379)
Cardiac muscle tissue development
(GO:0048738)
Cell fate specification
(GO:0001708)
Cellular senescence
(GO:0090398)
Chromatin
(GO:0000785)
Cochlea morphogenesis
(GO:0090103)
Cytoplasm
(GO:0005737)
Developmental growth involved in morphogenesis
(GO:0060560)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Embryonic camera-type eye morphogenesis
(GO:0048596)
Embryonic digit morphogenesis
(GO:0042733)
Endocardial cushion formation
(GO:0003272)
Endocardial cushion morphogenesis
(GO:0003203)
Epithelial tube branching involved in lung morphogenesis
(GO:0060441)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Heart morphogenesis
(GO:0003007)
Histone deacetylase binding
(GO:0042826)
Mammary placode formation
(GO:0060596)
Melanocyte proliferation
(GO:0097325)
Mesenchymal cell proliferation involved in lung development
(GO:0060916)
Multicellular organism development
(GO:0007275)
Muscle cell fate determination
(GO:0007521)
Negative regulation of cardiac chamber formation
(GO:1901211)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of heart looping
(GO:1901208)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neurogenesis
(GO:0022008)
Notch signaling pathway
(GO:0007219)
Nucleus
(GO:0005634)
Outflow tract morphogenesis
(GO:0003151)
Outflow tract septum morphogenesis
(GO:0003148)
Pharyngeal system development
(GO:0060037)
Pigment metabolic process involved in pigmentation
(GO:0043474)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of cell cycle g1/s phase transition
(GO:1902808)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to retinoic acid
(GO:0032526)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Roof of mouth development
(GO:0060021)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Smooth muscle cell differentiation
(GO:0051145)
Transcription regulator complex
(GO:0005667)
Ureteric peristalsis
(GO:0072105)

Other Information

Proteins

T-box transcription factor TBX2
Q3UET7_MOUSE

Genular Protein ID: 2349599838

Symbol: TBX2_MOUSE

Name: T-box transcription factor TBX2

UniProtKB Accession Codes:

Q60707 Q5SSP7

Database IDs:

Citations:

PubMed ID: 7920656

Title: An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus.

PubMed ID: 7920656

DOI: 10.1038/ng0794-383

PubMed ID: 10770922

Title: The gene encoding the T-box Factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes.

PubMed ID: 10770922

DOI: 10.1074/jbc.m000035200

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8853987

Title: Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development.

PubMed ID: 8853987

DOI: 10.1002/(sici)1097-0177(199608)206:4<379::aid-aja4>3.0.co;2-f

PubMed ID: 9710594

Title: Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter.

PubMed ID: 9710594

DOI: 10.1128/mcb.18.9.5099

PubMed ID: 11867218

Title: Murine Tbx2 contains domains that activate and repress gene transcription.

PubMed ID: 11867218

DOI: 10.1016/s0378-1119(01)00878-2

PubMed ID: 12023302

Title: Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation.

PubMed ID: 12023302

DOI: 10.1101/gad.222902

PubMed ID: 15459098

Title: Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development.

PubMed ID: 15459098

DOI: 10.1242/dev.01378

PubMed ID: 16222716

Title: Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway.

PubMed ID: 16222716

DOI: 10.1002/dvdy.20575

PubMed ID: 18025091

Title: UV-mediated regulation of the anti-senescence factor Tbx2.

PubMed ID: 18025091

DOI: 10.1074/jbc.m705651200

PubMed ID: 22186728

Title: Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfbeta2 pathway.

PubMed ID: 22186728

DOI: 10.1242/dev.067058

PubMed ID: 26486273

Title: Microphthalmia-associated transcription factor/T-box factor-2 axis acts through Cyclin D1 to regulate melanocyte proliferation.

PubMed ID: 26486273

DOI: 10.1111/cpr.12227

PubMed ID: 27720610

Title: Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.

PubMed ID: 27720610

DOI: 10.1016/j.devcel.2016.08.007

PubMed ID: 26971330

Title: The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2.

PubMed ID: 26971330

DOI: 10.1007/s11010-016-2680-7

PubMed ID: 28910203

Title: The T-Box Transcription Factor TBX2 Regulates Cell Proliferation in the Retinal Pigment Epithelium.

PubMed ID: 28910203

DOI: 10.1080/02713683.2017.1338351

PubMed ID: 30599067

Title: Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.

PubMed ID: 30599067

DOI: 10.1007/s00018-018-2998-2

PubMed ID: 33795231

Title: Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse.

PubMed ID: 33795231

DOI: 10.1242/dev.195651

PubMed ID: 33731112

Title: Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung.

PubMed ID: 33731112

DOI: 10.1186/s12931-021-01679-y

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 711
Mass: 75081
Checksum: 1C38BF1D25E1FF60
Sequence:

MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALGK PLPDPGLAGA 
AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE VEDDPKVTLE AKELWDQFHK 
LGTEMVITKS GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP 
EMPKRMYIHP DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN 
DILKLPYSTF RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT 
LPTLRLYEEH CKPERDGAES DASSCDPPPA REPPPSPSAA PSPLRLHRAR AEEKPGAADS 
DPEPERTGEE RSAAPLGRSP SRDASPARLT EPERSRERRS PERCSKEPTE GGGDGPFSLR 
SLEKERPEAR RKDEGRKDVG EGKEPSLAPL VVQTDSASPL GAGHLPGLAF SSHLHGQQFF 
GPLGAGQPLF LHPGQFAMGP GAFSAMGMGH LLASVAGGSG SSGGAGPGTA AGLDAGGLGP 
AASAASTAAP FPFHLSQHML ASQGIPMPTF GGLFPYPYTY MAAAAAAASA LPATSAAAAA 
AAAAGSLSRS PFLGSARPRL RFSPYQIPVT IPPSTSLLTT GLAAEGSKGG NSREPSPLPE 
LALRKVGGPS RGALSPSGSA KEAASELQSI QRLVSGLESQ RALSPGRESP K

Genular Protein ID: 1329252259

Symbol: Q3UET7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UET7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 701
Mass: 74083
Checksum: 9DE915AD729479F8
Sequence:

MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALGK PLPDPGLAGA AAAAAAAAAA 
AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE VEDDPKVTLE AKELWDQFHK LGTEMVITKS 
GRRMFPPFKV RVSGLDKKAK YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP 
DSPATGEQWM AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF 
RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT LPTLRLYEEH 
CKPERDGAES DASSCDPPPA REPPPSPSAA PSPLRLHRAR AEEKPGAADS DPEPERTGEE 
RSAAPLGRSP SRDASPARLT EPERSRERRS PERCSKEPTE GGGDGPFSLR SLEKERPEAR 
RKDEGRKDVG EGKEPSLAPL VVQTDSASPL GAGHLPGLAF SSHLHGQQFF GPLGAGQPLF 
LHPGQFAMGP GAFSAMGMGH LLASVAGGSG SSGGAGPGTA AGLDAGGLGP AASAASTAAP 
FPFHLSQHML ASQGIPMPTF GGLFPYPYTY MAAAAAAASA LPATSAAAAA AAAAGSLSRS 
PFLGSARPRL RFSPYQIPVT IPPSTSLLTT GLAAEGSKGG NSREPSPLPE LALRKVGGPS 
RGALSPSGSA KEAASELQSI QRLVSGLESQ RALSPGRESP K

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tbx2

Associated with

Other Information

An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. PubMed ID: 7920656

The gene encoding the T-box Factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes. PubMed ID: 10770922

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. PubMed ID: 8853987

Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter. PubMed ID: 9710594

Murine Tbx2 contains domains that activate and repress gene transcription. PubMed ID: 11867218

Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. PubMed ID: 12023302

Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. PubMed ID: 15459098

Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway. PubMed ID: 16222716

UV-mediated regulation of the anti-senescence factor Tbx2. PubMed ID: 18025091

Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfbeta2 pathway. PubMed ID: 22186728

Microphthalmia-associated transcription factor/T-box factor-2 axis acts through Cyclin D1 to regulate melanocyte proliferation. PubMed ID: 26486273

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung. PubMed ID: 27720610

The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2. PubMed ID: 26971330

The T-Box Transcription Factor TBX2 Regulates Cell Proliferation in the Retinal Pigment Epithelium. PubMed ID: 28910203

Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease. PubMed ID: 30599067

Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. PubMed ID: 33795231

Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung. PubMed ID: 33731112

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073