Details for: Tbx5

Gene ID: 21388

Symbol: Tbx5

Ensembl ID: ENSMUSG00000018263

Description: T-box 5

Associated with

  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Yap1- and wwtr1 (taz)-stimulated gene expression
    (R-MMU-2032785)
  • Atrial septum development
    (GO:0003283)
  • Atrial septum morphogenesis
    (GO:0060413)
  • Atrioventricular bundle cell differentiation
    (GO:0003167)
  • Atrioventricular node cell development
    (GO:0060928)
  • Atrioventricular node cell fate commitment
    (GO:0060929)
  • Atrioventricular valve morphogenesis
    (GO:0003181)
  • Bundle of his cell to purkinje myocyte communication by electrical coupling
    (GO:0086054)
  • Bundle of his development
    (GO:0003166)
  • Cardiac left ventricle formation
    (GO:0003218)
  • Cardiac muscle cell differentiation
    (GO:0055007)
  • Cardiac muscle cell proliferation
    (GO:0060038)
  • Cell-cell signaling
    (GO:0007267)
  • Cell-cell signaling involved in cardiac conduction
    (GO:0086019)
  • Cell fate specification
    (GO:0001708)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic forelimb morphogenesis
    (GO:0035115)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Endocardial cushion development
    (GO:0003197)
  • Forelimb morphogenesis
    (GO:0035136)
  • Heart development
    (GO:0007507)
  • Lung development
    (GO:0030324)
  • Morphogenesis of an epithelium
    (GO:0002009)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of cardiac muscle cell proliferation
    (GO:0060044)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pattern specification process
    (GO:0007389)
  • Pericardium development
    (GO:0060039)
  • Positive regulation of cardiac conduction
    (GO:1903781)
  • Positive regulation of cardiac muscle cell proliferation
    (GO:0060045)
  • Positive regulation of cardioblast differentiation
    (GO:0051891)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gap junction assembly
    (GO:1903598)
  • Positive regulation of secondary heart field cardioblast proliferation
    (GO:0072513)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex
    (GO:0032991)
  • Protein-dna complex
    (GO:0032993)
  • Protein binding
    (GO:0005515)
  • Regulation of atrial cardiac muscle cell membrane depolarization
    (GO:0060371)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sinoatrial node development
    (GO:0003163)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription regulator complex
    (GO:0005667)
  • Transdifferentiation
    (GO:0060290)
  • Ventricular cardiac muscle tissue development
    (GO:0003229)
  • Ventricular septum development
    (GO:0003281)

Other Information

Genular Protein ID: 592904736

Symbol: TBX5_MOUSE

Name: T-box transcription factor TBX5

UniProtKB Accession Codes:

P70326 Q9R003

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DIP 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 56 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10373308

Title: Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome.

PubMed ID: 10373308

DOI: 10.1006/dbio.1999.9298

PubMed ID: 8878690

Title: Evolution of mouse T-box genes by tandem duplication and cluster dispersion.

PubMed ID: 8878690

DOI: 10.1093/genetics/144.1.249

PubMed ID: 8853987

Title: Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development.

PubMed ID: 8853987

DOI: 10.1002/(sici)1097-0177(199608)206:4<379::aid-aja4>3.0.co;2-f

Sequence Information:

  • Length: 518
  • Mass: 57832
  • Checksum: 4990A802EB56624B
  • Sequence:
    • MADTDEGFGL ARTPLEPDSK DRSCDSKPES ALGAPSKSPS SPQAAFTQQG MEGIKVFLHE 
RELWLKFHEV GTEMIITKAG RRMFPSYKVK VTGLNPKTKY ILLMDIVPAD DHRYKFADNK 
WSVTGKAEPA MPGRLYVHPD SPATGAHWMR QLVSFQKLKL TNNHLDPFGH IILNSMHKYQ 
PRLHIVKADE NNGFGSKNTA FCTHVFPETA FIAVTSYQNH KITQLKIENN PFAKGFRGSD 
DLELHRMSRM QSKEYPVVPR STVRHKVTSN HSPFSSETRA LSTSSNLGSQ YQCENGVSGP 
SQDLLPPPNP YPLAQEHSQI YHCTKRKDEE CSSTEHPYKK PYMETSPSEE DTFYRSGYPQ 
QQGLSTSYRT ESAQRQACMY ASSAPPSEPV PSLEDISCNT WPSMPSYSSC TVTTVQPMDR 
LPYQHFSAHF TSGPLVPRLA GMANHGSPQL GEGMFQHQTS VAHQPVVRQC GPQTGLQSPG 
GLQPPEFLYT HGVPRTLSPH QYHSVHGVGM VPEWSENS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.