Details for: Tbx6

Gene ID: 21389

Symbol: Tbx6

Ensembl ID: ENSMUSG00000030699

Description: T-box 6

Associated with

  • Cell fate specification
    (GO:0001708)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Heart looping
    (GO:0001947)
  • Mesodermal cell fate specification
    (GO:0007501)
  • Mesoderm formation
    (GO:0001707)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of neuron maturation
    (GO:0014043)
  • Negative regulation of neuron projection development
    (GO:0010977)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Signal transduction involved in regulation of gene expression
    (GO:0023019)
  • Somite rostral/caudal axis specification
    (GO:0032525)
  • Vasculogenesis
    (GO:0001570)

Other Information

Genular Protein ID: 1818681206

Symbol: TBX6_MOUSE

Name: T-box transcription factor TBX6

UniProtKB Accession Codes:

P70327 B2RU37 Q5SDA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 21 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8878690

Title: Evolution of mouse T-box genes by tandem duplication and cluster dispersion.

PubMed ID: 8878690

DOI: 10.1093/genetics/144.1.249

PubMed ID: 8954725

Title: Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation.

PubMed ID: 8954725

DOI: 10.1006/dbio.1996.0326

PubMed ID: 15545628

Title: WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos.

PubMed ID: 15545628

DOI: 10.1101/gad.1248604

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9490412

Title: Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6.

PubMed ID: 9490412

DOI: 10.1038/35624

PubMed ID: 18575602

Title: Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling.

PubMed ID: 18575602

DOI: 10.1371/journal.pone.0002511

PubMed ID: 21331042

Title: Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells.

PubMed ID: 21331042

DOI: 10.1038/nature09729

Sequence Information:

  • Length: 436
  • Mass: 47006
  • Checksum: DBAAD94C88E9CC4B
  • Sequence:
    • MYHPRELYPS LGTGYRLGHP QPGADSTFPP ALTEGYRYPD LDTSKLDCFL SGIEAAPHTL 
AAAAPLPLLP SALGPETAPP PPEALHSLPG VSLSLENQEL WKEFSAVGTE MIITKAGRRM 
FPACRVSVTG LDPEARYLFL LDVVPVDGAR YRWQGQHWEP SGKAEPRLPD RVYIHPDSPA 
TGAHWMRQPV SFHRVKLTNS TLDPHGHLIL HSMHKYQPRI HLVRATQLCS QHWGGVASFR 
FPETTFISVT AYQNPRITQL KIAANPFAKG FRENGRNCKR ERDARVKRKL RGPEPVATEA 
CGSGDTPGGP CDSTLGGDIR DSDPEQAPTP QEAASASAPP CGGPSAEAYL LHPAAFHGAP 
SHLPARTPSF AEAPDPGRPA PYSAAFLDLQ PGPGGSAYQA APSVPSFAPH FIQGGPFPLP 
YPGPGGYLDM GSKPMY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.