Details for: ALCAM

Gene ID: 214

Symbol: ALCAM

Ensembl ID: ENSG00000170017

Description: activated leukocyte cell adhesion molecule

Associated with

Other Information

Genular Protein ID: 2116669436

Symbol: CD166_HUMAN

Name: CD166 antigen

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7760007

Title: Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand.

PubMed ID: 7760007

DOI: 10.1084/jem.181.6.2213

PubMed ID: 15496415

Title: Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function.

PubMed ID: 15496415

DOI: 10.1074/jbc.m407776200

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9502422

Title: MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule).

PubMed ID: 9502422

PubMed ID: 8823162

Title: Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM.

PubMed ID: 8823162

DOI: 10.1021/bi961038k

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15048703

Title: Frontline: Optimal T cell activation requires the engagement of CD6 and CD166.

PubMed ID: 15048703

DOI: 10.1002/eji.200424856

PubMed ID: 15294938

Title: Relevance of CD6-mediated interactions in T cell activation and proliferation.

PubMed ID: 15294938

DOI: 10.4049/jimmunol.173.4.2262

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16352806

Title: Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.

PubMed ID: 16352806

DOI: 10.1182/blood-2005-09-3881

PubMed ID: 16914752

Title: CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.

PubMed ID: 16914752

DOI: 10.1128/mcb.00688-06

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23169771

Title: Novel role for ALCAM in lymphatic network formation and function.

PubMed ID: 23169771

DOI: 10.1096/fj.12-217844

PubMed ID: 24740813

Title: CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche.

PubMed ID: 24740813

DOI: 10.1182/blood-2014-03-565721

PubMed ID: 24945728

Title: Modulation of CD6 function through interaction with galectin-1 and -3.

PubMed ID: 24945728

DOI: 10.1016/j.febslet.2014.05.064

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29263213

Title: ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth.

PubMed ID: 29263213

DOI: 10.4049/jimmunol.1700553

PubMed ID: 8520490

Title: Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM.

PubMed ID: 8520490

DOI: 10.1002/pro.5560040822

PubMed ID: 26146185

Title: Structures of CD6 and its ligand CD166 give insight into their interaction.

PubMed ID: 26146185

DOI: 10.1016/j.str.2015.05.019

Sequence Information:

  • Length: 583
  • Mass: 65102
  • Checksum: 68FEFD67C14B0C57
  • Sequence:
  • MESKGASSCR LLFCLLISAT VFRPGLGWYT VNSAYGDTII IPCRLDVPQN LMFGKWKYEK 
    PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL NLSENYTLSI SNARISDEKR FVCMLVTEDN 
    VFEAPTIVKV FKQPSKPEIV SKALFLETEQ LKKLGDCISE DSYPDGNITW YRNGKVLHPL 
    EGAVVIIFKK EMDPVTQLYT MTSTLEYKTT KADIQMPFTC SVTYYGPSGQ KTIHSEQAVF 
    DIYYPTEQVT IQVLPPKNAI KEGDNITLKC LGNGNPPPEE FLFYLPGQPE GIRSSNTYTL 
    TDVRRNATGD YKCSLIDKKS MIASTAITVH YLDLSLNPSG EVTRQIGDAL PVSCTISASR 
    NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE GLKKRESLTL IVEGKPQIKM 
    TKKTDPSGLS KTIICHVEGF PKPAIQWTIT GSGSVINQTE ESPYINGRYY SKIIISPEEN 
    VTLTCTAENQ LERTVNSLNV SAISIPEHDE ADEISDENRE KVNDQAKLIV GIVVGLLLAA 
    LVAGVVYWLY MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA

Genular Protein ID: 1452217731

Symbol: B3KNN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 555
  • Mass: 61941
  • Checksum: D2323DF06D268153
  • Sequence:
  • MESKGASSCR LLFCLLISAT VFRPGLGWYT VNSAYGDTII IPCRLDVPQN LMFGKWKYEK 
    PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL NLSENYTLSI SNARISDEKR FVCMLVTEDN 
    VFEAPTIVKV FKQPSKPEIV SKALFLETEQ LKKLGDCISE DSYPDGNITW YRNGKVLHPL 
    EGAVVIIFKK EMDPVTQLYT MTSTLEYKTT KADIQMPFTC SVTYYGPSGQ KTIHSEQAVF 
    DIYYPTEQVT IQVLPPKNAI KEGDNITLKC LGNGNPPPEE FLFYLPGQPE GIRSSNTYTL 
    MDVRRNATGD YKCSLIDKKS MIASTAITVH YLDLSLNPSG EVTRQIGDAL PVSCTISASR 
    NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE GLKKRESLTL IVEGKPQIKM 
    TKKTDPSGLS KTIICHVEGF PKPAIQWTIT GSGSVINQTE ESPYINGRYY SKIIISPEEN 
    VTLTCTAENQ LERTVNSLNV SAISIPEHDE ADEISDENRE KVNDQAKLIV GIVVGLLLAA 
    LVAGVVYWLY MKKSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.