Details for: ALCAM

Gene ID: 214

Symbol: ALCAM

Ensembl ID: ENSG00000170017

Description: activated leukocyte cell adhesion molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 8.49
    Marker Score: 11940
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 6.23
    Marker Score: 25956.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.36
    Marker Score: 10429
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 3.6
    Marker Score: 1189
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.44
    Marker Score: 25940
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.37
    Marker Score: 4062
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.31
    Marker Score: 2212
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.24
    Marker Score: 10630
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 3.21
    Marker Score: 924.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3
    Marker Score: 1749
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.91
    Marker Score: 10007
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.81
    Marker Score: 6450
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.8
    Marker Score: 1383
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.79
    Marker Score: 1321.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.78
    Marker Score: 5076
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.78
    Marker Score: 24136
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.73
    Marker Score: 1895
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6
    Marker Score: 41776
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.58
    Marker Score: 2950
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.58
    Marker Score: 2232
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.5
    Marker Score: 5486.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.44
    Marker Score: 52045.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.37
    Marker Score: 9808
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.31
    Marker Score: 15028.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.29
    Marker Score: 1132
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.29
    Marker Score: 662
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.28
    Marker Score: 2817
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.26
    Marker Score: 4301
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.19
    Marker Score: 16275.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.17
    Marker Score: 20435
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.16
    Marker Score: 38324.5
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.13
    Marker Score: 584
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.11
    Marker Score: 13724
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.11
    Marker Score: 7800
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.09
    Marker Score: 1216.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.03
    Marker Score: 1756
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.01
    Marker Score: 10584
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.99
    Marker Score: 1307
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.97
    Marker Score: 2460
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.95
    Marker Score: 9013
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.94
    Marker Score: 1130
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.94
    Marker Score: 1003
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.93
    Marker Score: 2248
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.91
    Marker Score: 19760
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.91
    Marker Score: 557
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.88
    Marker Score: 48164
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.88
    Marker Score: 1978
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.82
    Marker Score: 36135
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.81
    Marker Score: 4923
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.79
    Marker Score: 10855.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.76
    Marker Score: 6816
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.76
    Marker Score: 2126
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.76
    Marker Score: 5008
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.75
    Marker Score: 966
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.74
    Marker Score: 60200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.74
    Marker Score: 811
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.69
    Marker Score: 64215.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.68
    Marker Score: 768
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.68
    Marker Score: 752
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.65
    Marker Score: 3120
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.63
    Marker Score: 590
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.6
    Marker Score: 59107
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.57
    Marker Score: 417
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.56
    Marker Score: 396
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.54
    Marker Score: 2373
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.53
    Marker Score: 3113
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.51
    Marker Score: 4344.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.5
    Marker Score: 561
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.47
    Marker Score: 3811.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.47
    Marker Score: 7883
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 166922
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.44
    Marker Score: 981
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.43
    Marker Score: 5531
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.43
    Marker Score: 6180
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.43
    Marker Score: 689
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.4
    Marker Score: 565
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.4
    Marker Score: 2481
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.39
    Marker Score: 583
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.39
    Marker Score: 5800.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.38
    Marker Score: 8886
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.38
    Marker Score: 436
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.36
    Marker Score: 11693
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.36
    Marker Score: 2004
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.36
    Marker Score: 3093.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.32
    Marker Score: 1214
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.28
    Marker Score: 637.5
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.28
    Marker Score: 327
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.27
    Marker Score: 1287
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.25
    Marker Score: 4441
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.24
    Marker Score: 2932
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.24
    Marker Score: 6679
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.21
    Marker Score: 2037
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.21
    Marker Score: 854
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.21
    Marker Score: 1076.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.2
    Marker Score: 4898
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.19
    Marker Score: 384
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.18
    Marker Score: 1899
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.18
    Marker Score: 452
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.16
    Marker Score: 1033
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.15
    Marker Score: 4781

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Other Information

**Key characteristics:** - ALCAM is a transmembrane protein with a single IgV domain and a single IgC domain. - It is expressed on a variety of cell types, including epithelial cells, neurons, and endothelial cells. - It is involved in cell adhesion to extracellular matrix proteins, as well as in axon guidance and the development of the nervous system. **Pathways and functions:** - ALCAM is involved in cell adhesion by binding to extracellular matrix proteins, which are important for cell adhesion. - It is also involved in axon guidance, as it is expressed on neurons and is important for the guidance of axons during development. - ALCAM is also involved in the development of the nervous system, as it is expressed on neurons and is important for the guidance of axons during development. **Clinical significance:** - Mutations in the ALCAM gene have been linked to several human diseases, including autism, schizophrenia, and developmental disorders. - ALCAM is a promising target for cancer immunotherapy, as it is expressed on cancer cells and is involved in their migration and invasion. - ALCAM is a promising target for the treatment of neurodegenerative diseases, such as Alzheimer's disease, as it is expressed on neurons and is involved in the development of the nervous system.

Genular Protein ID: 2116669436

Symbol: CD166_HUMAN

Name: CD166 antigen

UniProtKB Accession Codes:

Q13740 B2RNS3 B4DTU0 O60892 Q1HGM8 Q1HGM9 Q6PEY4 Q6ZS95

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 14 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7760007

Title: Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand.

PubMed ID: 7760007

DOI: 10.1084/jem.181.6.2213

PubMed ID: 15496415

Title: Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function.

PubMed ID: 15496415

DOI: 10.1074/jbc.m407776200

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9502422

Title: MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule).

PubMed ID: 9502422

PubMed ID: 8823162

Title: Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM.

PubMed ID: 8823162

DOI: 10.1021/bi961038k

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15048703

Title: Frontline: Optimal T cell activation requires the engagement of CD6 and CD166.

PubMed ID: 15048703

DOI: 10.1002/eji.200424856

PubMed ID: 15294938

Title: Relevance of CD6-mediated interactions in T cell activation and proliferation.

PubMed ID: 15294938

DOI: 10.4049/jimmunol.173.4.2262

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16352806

Title: Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.

PubMed ID: 16352806

DOI: 10.1182/blood-2005-09-3881

PubMed ID: 16914752

Title: CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.

PubMed ID: 16914752

DOI: 10.1128/mcb.00688-06

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23169771

Title: Novel role for ALCAM in lymphatic network formation and function.

PubMed ID: 23169771

DOI: 10.1096/fj.12-217844

PubMed ID: 24740813

Title: CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche.

PubMed ID: 24740813

DOI: 10.1182/blood-2014-03-565721

PubMed ID: 24945728

Title: Modulation of CD6 function through interaction with galectin-1 and -3.

PubMed ID: 24945728

DOI: 10.1016/j.febslet.2014.05.064

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29263213

Title: ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth.

PubMed ID: 29263213

DOI: 10.4049/jimmunol.1700553

PubMed ID: 8520490

Title: Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM.

PubMed ID: 8520490

DOI: 10.1002/pro.5560040822

PubMed ID: 26146185

Title: Structures of CD6 and its ligand CD166 give insight into their interaction.

PubMed ID: 26146185

DOI: 10.1016/j.str.2015.05.019

Sequence Information:

  • Length: 583
  • Mass: 65102
  • Checksum: 68FEFD67C14B0C57
  • Sequence:
    • MESKGASSCR LLFCLLISAT VFRPGLGWYT VNSAYGDTII IPCRLDVPQN LMFGKWKYEK 
PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL NLSENYTLSI SNARISDEKR FVCMLVTEDN 
VFEAPTIVKV FKQPSKPEIV SKALFLETEQ LKKLGDCISE DSYPDGNITW YRNGKVLHPL 
EGAVVIIFKK EMDPVTQLYT MTSTLEYKTT KADIQMPFTC SVTYYGPSGQ KTIHSEQAVF 
DIYYPTEQVT IQVLPPKNAI KEGDNITLKC LGNGNPPPEE FLFYLPGQPE GIRSSNTYTL 
TDVRRNATGD YKCSLIDKKS MIASTAITVH YLDLSLNPSG EVTRQIGDAL PVSCTISASR 
NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE GLKKRESLTL IVEGKPQIKM 
TKKTDPSGLS KTIICHVEGF PKPAIQWTIT GSGSVINQTE ESPYINGRYY SKIIISPEEN 
VTLTCTAENQ LERTVNSLNV SAISIPEHDE ADEISDENRE KVNDQAKLIV GIVVGLLLAA 
LVAGVVYWLY MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA

Genular Protein ID: 1452217731

Symbol: B3KNN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNN9

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 555
  • Mass: 61941
  • Checksum: D2323DF06D268153
  • Sequence:
    • MESKGASSCR LLFCLLISAT VFRPGLGWYT VNSAYGDTII IPCRLDVPQN LMFGKWKYEK 
PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL NLSENYTLSI SNARISDEKR FVCMLVTEDN 
VFEAPTIVKV FKQPSKPEIV SKALFLETEQ LKKLGDCISE DSYPDGNITW YRNGKVLHPL 
EGAVVIIFKK EMDPVTQLYT MTSTLEYKTT KADIQMPFTC SVTYYGPSGQ KTIHSEQAVF 
DIYYPTEQVT IQVLPPKNAI KEGDNITLKC LGNGNPPPEE FLFYLPGQPE GIRSSNTYTL 
MDVRRNATGD YKCSLIDKKS MIASTAITVH YLDLSLNPSG EVTRQIGDAL PVSCTISASR 
NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE GLKKRESLTL IVEGKPQIKM 
TKKTDPSGLS KTIICHVEGF PKPAIQWTIT GSGSVINQTE ESPYINGRYY SKIIISPEEN 
VTLTCTAENQ LERTVNSLNV SAISIPEHDE ADEISDENRE KVNDQAKLIV GIVVGLLLAA 
LVAGVVYWLY MKKSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.