Genular: Defining Cellular Identity and Function

Details for: Skp1

Gene ID: 21402

Symbol: Skp1

Ensembl ID: ENSMUSG00000036309

Description: S-phase kinase-associated protein 1

Associated with

Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Cytokine signaling in immune system
(R-MMU-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-MMU-5607761)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Degradation of gli1 by the proteasome
(R-MMU-5610780)
Dna replication
(R-MMU-69306)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fbxl7 down-regulates aurka during mitotic entry and in early mitosis
(R-MMU-8854050)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
G1 phase
(R-MMU-69236)
G1/s transition
(R-MMU-69206)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-MMU-9762114)
Hedgehog 'off' state
(R-MMU-5610787)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Interleukin-17 signaling
(R-MMU-448424)
Iron uptake and transport
(R-MMU-917937)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Map3k8 (tpl2)-dependent mapk1/3 activation
(R-MMU-5684264)
Map kinase activation
(R-MMU-450294)
Metabolism of proteins
(R-MMU-392499)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Neddylation
(R-MMU-8951664)
Nik-->noncanonical nf-kb signaling
(R-MMU-5676590)
Nuclear events mediated by nfe2l2
(R-MMU-9759194)
Orc1 removal from chromatin
(R-MMU-68949)
Post-translational protein modification
(R-MMU-597592)
Prolactin receptor signaling
(R-MMU-1170546)
Regulation of apc/c activators between g1/s and early anaphase
(R-MMU-176408)
Regulation of bach1 activity
(R-MMU-9708530)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Regulation of runx2 expression and activity
(R-MMU-8939902)
Rna polymerase ii transcription
(R-MMU-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Scf-beta-trcp mediated degradation of emi1
(R-MMU-174113)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Tcr signaling
(R-MMU-202403)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transport of small molecules
(R-MMU-382551)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Beta-catenin binding
(GO:0008013)
Chromatin remodeling
(GO:0006338)
Cullin family protein binding
(GO:0097602)
F-box domain binding
(GO:1990444)
Molecular function activator activity
(GO:0140677)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein monoubiquitination
(GO:0006513)
Protein polyubiquitination
(GO:0000209)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase-substrate adaptor activity
(GO:1990756)
Ubiquitin ligase complex scaffold activity
(GO:0160072)

Other Information

Proteins

S-phase kinase-associated protein 1

Genular Protein ID: 2997892724

Symbol: SKP1_MOUSE

Name: S-phase kinase-associated protein 1

UniProtKB Accession Codes:

Q9WTX5 Q8C5H6

Database IDs:

Citations:

PubMed ID: 10097128

Title: Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

PubMed ID: 10097128

DOI: 10.1073/pnas.96.7.3859

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9990853

Title: Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP.

PubMed ID: 9990853

DOI: 10.1101/gad.13.3.284

PubMed ID: 11735228

Title: Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.

PubMed ID: 11735228

DOI: 10.1006/geno.2001.6658

PubMed ID: 12140560

Title: E3 ubiquitin ligase that recognizes sugar chains.

PubMed ID: 12140560

DOI: 10.1038/nature00890

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19996097

Title: Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.

PubMed ID: 19996097

DOI: 10.1074/jbc.m109.046284

PubMed ID: 23319590

Title: SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation.

PubMed ID: 23319590

DOI: 10.1074/jbc.m112.426882

PubMed ID: 29937374

Title: Autophagy regulates the liver clock and glucose metabolism by degrading CRY1.

PubMed ID: 29937374

DOI: 10.1016/j.cmet.2018.05.023

Sequence Information:

Length: 163
Mass: 18672
Checksum: AE184C00BE6556DB
Sequence:

MPTIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV NAAILKKVIQ 
WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL FELILAANYL DIKGLLDVTC 
KTVANMIKGK TPEEIRKTFN IKNDFTEEEE AQVRKENQWC EEK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Skp1

Associated with

Other Information

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. PubMed ID: 10097128

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. PubMed ID: 9990853

Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. PubMed ID: 11735228

E3 ubiquitin ligase that recognizes sugar chains. PubMed ID: 12140560

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. PubMed ID: 19996097

SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation. PubMed ID: 23319590

Autophagy regulates the liver clock and glucose metabolism by degrading CRY1. PubMed ID: 29937374