Genular: Defining Cellular Identity and Function

Details for: Hnf1a

Gene ID: 21405

Symbol: Hnf1a

Ensembl ID: ENSMUSG00000029556

Description: HNF1 homeobox A

Associated with

Apoptotic nuclear changes
(GO:0030262)
Bile acid and bile salt transport
(GO:0015721)
Bile acid biosynthetic process
(GO:0006699)
Blastocyst development
(GO:0001824)
Bone resorption
(GO:0045453)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to leucine
(GO:0071233)
Cellular response to rapamycin
(GO:0072752)
Cholesterol metabolic process
(GO:0008203)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Embryonic limb morphogenesis
(GO:0030326)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid transport
(GO:0015908)
Glucose homeostasis
(GO:0042593)
Glucose import
(GO:0046323)
Heme biosynthetic process
(GO:0006783)
Identical protein binding
(GO:0042802)
Insulin secretion
(GO:0030073)
Liver development
(GO:0001889)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of mirna processing
(GO:1903799)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Pancreas development
(GO:0031016)
Paraxial mesoderm formation
(GO:0048341)
Photoreceptor outer segment
(GO:0001750)
Placenta development
(GO:0001890)
Positive regulation of atp biosynthetic process
(GO:2001171)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mitochondrial membrane potential
(GO:0010918)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Pronucleus
(GO:0045120)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein localization
(GO:0008104)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of hormone secretion
(GO:0046883)
Regulation of nadp metabolic process
(GO:1902031)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of wnt signaling pathway
(GO:0030111)
Renal glucose absorption
(GO:0035623)
Reproductive structure development
(GO:0048608)
Response to glucose
(GO:0009749)
Response to oxidative stress
(GO:0006979)
Reverse cholesterol transport
(GO:0043691)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription coregulator binding
(GO:0001221)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

Hepatocyte nuclear factor 1-alpha
Q66JY7_MOUSE

Genular Protein ID: 3926187934

Symbol: HNF1A_MOUSE

Name: Hepatocyte nuclear factor 1-alpha

UniProtKB Accession Codes:

P22361 E9QP86

Database IDs:

Citations:

PubMed ID: 2263635

Title: Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1.

PubMed ID: 2263635

DOI: 10.1073/pnas.87.24.9838

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 1354855

Title: Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1).

PubMed ID: 1354855

DOI: 10.1093/nar/20.16.4199

PubMed ID: 9566924

Title: Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse.

PubMed ID: 9566924

DOI: 10.1128/mcb.18.5.3059

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 19289501

Title: Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.

PubMed ID: 19289501

DOI: 10.1128/mcb.01389-08

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 30555544

Title: Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity.

PubMed ID: 30555544

DOI: 10.7150/thno.28676

PubMed ID: 11106484

Title: High-resolution structure of the HNF-1alpha dimerization domain.

PubMed ID: 11106484

DOI: 10.1021/bi001996t

PubMed ID: 10966642

Title: Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.

PubMed ID: 10966642

DOI: 10.1038/78966

PubMed ID: 11439029

Title: The dimerization domain of HNF-1alpha: structure and plasticity of an intertwined four-helix bundle with application to diabetes mellitus.

PubMed ID: 11439029

DOI: 10.1006/jmbi.2001.4780

Sequence Information:

Length: 628
Mass: 67253
Checksum: 737920D47BA1F081
Sequence:

MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLMVG EGPLDKGESC GGSRGDLTEL 
PNGLGETRGS EDDTDDDGED FAPPILKELE NLSPEEAAHQ KAVVESLLQE DPWRVAKMVK 
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA 
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE 
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYNGPP PGPGPGPALP 
AHSSPGLPTT TLSPSKVHGV RYGQSATSEA AEVPSSSGGP LVTVSAALHQ VSPTGLEPSS 
LLSTEAKLVS ATGGPLPPVS TLTALHSLEQ TSPGLNQQPQ NLIMASLPGV MTIGPGEPAS 
LGPTFTNTGA STLVIGLAST QAQSVPVINS MGSSLTTLQP VQFSQPLHPS YQQPLMPPVQ 
SHVAQSPFMA TMAQLQSPHA LYSHKPEVAQ YTHTSLLPQT MLITDTNLST LASLTPTKQV 
FTSDTEASSE PGLHEPPSPA TTIHIPSQDP SNIQHLQPAH RLSTSPTVSS SSLVLYQSSD 
SNGHSHLLPS NHSVIETFIS TQMASSSQ

Genular Protein ID: 2568938318

Symbol: Q66JY7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q66JY7

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 628
Mass: 67226
Checksum: 1C8D8B3AA685D653
Sequence:

MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLMVG EGPLDKGESC GGSRGDLTEL 
PNGLGETRGS EDDTDDDGED FAPPILKELE NLSPEEAAHQ KAVVESLLQE DPWRVAKMVK 
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA 
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKSPSKEERE TLVEECNRAE 
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYNGPP PGPGPGPALP 
AHSSPGLPTT TLSPSKVHGV RYGQSATSEA AEVPSSSGGP LVTVSAALHQ VSPTGLEPSS 
LLSTEAKLVS ATGGPLPPVS TLTALHSLEQ TSPGLNQQPQ NLIMASLPGV MTIGPGEPAS 
LGPTFTNTGA STLVIGLAST QAQSVPVINS MGSSLTTLQP VQFSQPLHPS YQQPLMPPVQ 
SHVAQSPFMA TMAQLQSPHA LYSHKPEVAQ YTHTSLLPQT MLITDTNLST LASLTPTKQV 
FTSDTEASSE PGLHEPPSPA TTIHIPSQDP SNIQHLQPAH RLSTSPTVSS SSLVLYQSSD 
SNGHSHLLPS NHSVIETFIS TQMASSSQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hnf1a

Associated with

Other Information

Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. PubMed ID: 2263635

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1). PubMed ID: 1354855

Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. PubMed ID: 9566924

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. PubMed ID: 18630941

Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver. PubMed ID: 19289501

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity. PubMed ID: 30555544

High-resolution structure of the HNF-1alpha dimerization domain. PubMed ID: 11106484

Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha. PubMed ID: 10966642

The dimerization domain of HNF-1alpha: structure and plasticity of an intertwined four-helix bundle with application to diabetes mellitus. PubMed ID: 11439029

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334