Details for: Tcf15

Gene ID: 21407

Symbol: Tcf15

Ensembl ID: ENSMUSG00000068079

Description: transcription factor 15

Associated with

  • Anterior/posterior pattern specification
    (GO:0009952)
  • Bhlh transcription factor binding
    (GO:0043425)
  • Cell differentiation
    (GO:0030154)
  • Developmental process
    (GO:0032502)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • E-box binding
    (GO:0070888)
  • Ear development
    (GO:0043583)
  • Establishment of epithelial cell apical/basal polarity
    (GO:0045198)
  • Mesenchymal to epithelial transition
    (GO:0060231)
  • Multicellular organism development
    (GO:0007275)
  • Muscle organ development
    (GO:0007517)
  • Muscle organ morphogenesis
    (GO:0048644)
  • Negative regulation of hematopoietic stem cell differentiation
    (GO:1902037)
  • Neuromuscular process controlling posture
    (GO:0050884)
  • Nucleus
    (GO:0005634)
  • Paraxial mesoderm development
    (GO:0048339)
  • Positive regulation of stem cell differentiation
    (GO:2000738)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Post-anal tail morphogenesis
    (GO:0036342)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of extracellular matrix organization
    (GO:1903053)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Respiratory system process
    (GO:0003016)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Skeletal system morphogenesis
    (GO:0048705)
  • Somitogenesis
    (GO:0001756)
  • Stem cell population maintenance
    (GO:0019827)

Other Information

Genular Protein ID: 3931670750

Symbol: TCF15_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q60756 Q60788

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 1 GO 27 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 7729571

Title: Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites.

PubMed ID: 7729571

DOI: 10.1006/dbio.1995.1081

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8825648

Title: Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2.

PubMed ID: 8825648

DOI: 10.1006/geno.1995.1282

PubMed ID: 8041747

Title: Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites.

PubMed ID: 8041747

DOI: 10.1073/pnas.91.15.7066

PubMed ID: 7597044

Title: Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development.

PubMed ID: 7597044

DOI: 10.1073/pnas.92.13.5870

PubMed ID: 8955271

Title: Requirement of the paraxis gene for somite formation and musculoskeletal patterning.

PubMed ID: 8955271

DOI: 10.1038/384570a0

PubMed ID: 15226298

Title: Paraxis is a basic helix-loop-helix protein that positively regulates transcription through binding to specific E-box elements.

PubMed ID: 15226298

DOI: 10.1074/jbc.m401319200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23395635

Title: Tcf15 primes pluripotent cells for differentiation.

PubMed ID: 23395635

DOI: 10.1016/j.celrep.2013.01.017

PubMed ID: 24038871

Title: Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis.

PubMed ID: 24038871

DOI: 10.1002/dvdy.24033

PubMed ID: 25561514

Title: Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake.

PubMed ID: 25561514

DOI: 10.1161/circulationaha.114.013721

PubMed ID: 32669716

Title: Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis.

PubMed ID: 32669716

DOI: 10.1038/s41586-020-2503-6

Sequence Information:

  • Length: 195
  • Mass: 20721
  • Checksum: F659B94C5F125E56
  • Sequence:
    • MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGLEAARRG PGPGSGRRAS 
NGAGPVVVVR QRQAANARER DRTQSVNTAF TALRTLIPTE PVDRKLSKIE TLRLASSYIA 
HLANVLLLGD AADDGQPCFR AAGGGKSAVP AADGRQPRSI CTFCLSNQRK GGSRRDLGGS 
CLKVRGVAPL RGPRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.