Genular: Defining Cellular Identity and Function

Details for: Hnf1b

Gene ID: 21410

Symbol: Hnf1b

Ensembl ID: ENSMUSG00000020679

Description: HNF1 homeobox B

Associated with

Anterior/posterior pattern specification
(GO:0009952)
Apoptotic process
(GO:0006915)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Circadian regulation of gene expression
(GO:0032922)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryonic digestive tract morphogenesis
(GO:0048557)
Embryonic morphogenesis
(GO:0048598)
Endocrine pancreas development
(GO:0031018)
Endodermal cell fate specification
(GO:0001714)
Endoderm development
(GO:0007492)
Endoderm formation
(GO:0001706)
Epithelial cell proliferation
(GO:0050673)
Epithelium development
(GO:0060429)
Genitalia development
(GO:0048806)
Hepatoblast differentiation
(GO:0061017)
Hindbrain development
(GO:0030902)
Identical protein binding
(GO:0042802)
Inner cell mass cell differentiation
(GO:0001826)
Insulin secretion
(GO:0030073)
Intracellular membrane-bounded organelle
(GO:0043231)
Kidney development
(GO:0001822)
Kidney morphogenesis
(GO:0060993)
Liver development
(GO:0001889)
Mesenchymal cell apoptotic process involved in metanephros development
(GO:1900200)
Mesonephric duct development
(GO:0072177)
Mesonephric duct formation
(GO:0072181)
Mesonephric tubule development
(GO:0072164)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
(GO:0061296)
Negative regulation of mesenchymal cell apoptotic process involved in metanephros development
(GO:1900212)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nephric duct development
(GO:0072176)
Nephric duct formation
(GO:0072179)
Notch signaling pathway
(GO:0007219)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pancreas development
(GO:0031016)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Pronephric nephron tubule development
(GO:0039020)
Pronephros development
(GO:0048793)
Protein-containing complex binding
(GO:0044877)
Protein-dna complex assembly
(GO:0065004)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of branch elongation involved in ureteric bud branching
(GO:0072095)
Regulation of pronephros size
(GO:0035565)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of wnt signaling pathway
(GO:0030111)
Response to glucose
(GO:0009749)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Transcription regulator complex
(GO:0005667)
Ureteric bud elongation
(GO:0060677)

Other Information

Proteins

Hepatocyte nuclear factor 1-beta

Genular Protein ID: 727891872

Symbol: HNF1B_MOUSE

Name: Hepatocyte nuclear factor 1-beta

UniProtKB Accession Codes:

P27889 Q5NC37 Q8R162 Q9CS26 Q9R1W1 Q9R1W2 Q9WTL5 Q9WTL6

Database IDs:

Citations:

PubMed ID: 1673925

Title: LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia.

PubMed ID: 1673925

DOI: 10.1002/j.1460-2075.1991.tb07664.x

PubMed ID: 10331425

Title: Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait.

PubMed ID: 10331425

DOI: 10.2337/diabetes.48.5.1168

PubMed ID: 11456274

Title: Sequence analysis of candidate genes for common susceptibility to type 1 and type 2 diabetes in mice.

PubMed ID: 11456274

DOI: 10.1507/endocrj.48.241

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 558
Mass: 61588
Checksum: D4F2BC92B64374A6
Sequence:

MVSKLTSLQQ ELLSALLSSG VTKEVLIQAL EELLPSPNFG VKLETLPLSP GSGADLDTKP 
VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT EEAAEQRAEV DRMLSEDPWR 
AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL SQHLNKGTPM KTQKRAALYT WYVRKQREIL 
RQFNQTVQSS GNMTDKSSQD QLLFLFPEFS QQNQGPGQSE DTCSEPTNKK MRRNRFKWGP 
ASQQILYQAY DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF 
ANRRKEEAFR QKLAMDAYSS NQTHNLNPLL THGSPHHQPS SSPPNKMSGV RYNQPGNNEV 
TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHSLLSPDS KMQITVSGGG LPPVSTLTNI 
HSLSHHNPQQ SQNLIMTPLS GVMAIAQSLN TSQAQGVPVI NSVASSLAAL QPVQFSQQLH 
SPHQQPLMQQ SPGSHMAQQP FMAAVTQLQN SHMYAHKQEP PQYSHTSRFP SAMVVTDTSS 
INTLTSMSSS KQCPLQAW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hnf1b

Associated with

Other Information

LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. PubMed ID: 1673925

Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait. PubMed ID: 10331425

Sequence analysis of candidate genes for common susceptibility to type 1 and type 2 diabetes in mice. PubMed ID: 11456274

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079