Genular: Defining Cellular Identity and Function

Details for: Tcf7

Gene ID: 21414

Symbol: Tcf7

Ensembl ID: ENSMUSG00000000782

Description: transcription factor 7, T cell specific

Associated with

Deactivation of the beta-catenin transactivating complex
(R-MMU-3769402)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Formation of the beta-catenin:tcf transactivating complex
(R-MMU-201722)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Repression of wnt target genes
(R-MMU-4641265)
Rna polymerase ii transcription
(R-MMU-73857)
Runx3 regulates wnt signaling
(R-MMU-8951430)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Transcriptional regulation by runx3
(R-MMU-8878159)
Alpha-beta t cell differentiation
(GO:0046632)
Beta-catenin-tcf complex
(GO:1990907)
Beta-catenin binding
(GO:0008013)
Canonical wnt signaling pathway
(GO:0060070)
Canonical wnt signaling pathway involved in negative regulation of apoptotic process
(GO:0044336)
Cellular response to interleukin-4
(GO:0071353)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity
(GO:0001217)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Embryonic digestive tract morphogenesis
(GO:0048557)
Embryonic genitalia morphogenesis
(GO:0030538)
Embryonic hindgut morphogenesis
(GO:0048619)
Euchromatin
(GO:0000791)
Gamma-delta t cell differentiation
(GO:0042492)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube development
(GO:0021915)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gamma-delta t cell differentiation
(GO:0045586)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
T cell receptor v(d)j recombination
(GO:0033153)
Transcription cis-regulatory region binding
(GO:0000976)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

TCF7_MOUSE
Q80UF1_MOUSE

Genular Protein ID: 2192384256

Symbol: TCF7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q00417

Database IDs:

Citations:

PubMed ID: 1827138

Title: Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.

PubMed ID: 1827138

DOI: 10.1084/jem.173.5.1133

PubMed ID: 8622675

Title: Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties.

PubMed ID: 8622675

DOI: 10.1128/mcb.16.3.745

PubMed ID: 10489374

Title: Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

PubMed ID: 10489374

DOI: 10.1126/science.285.5435.1923

PubMed ID: 11477404

Title: The beta-catenin-TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.

PubMed ID: 11477404

DOI: 10.1038/90623

PubMed ID: 17218525

Title: Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13.

PubMed ID: 17218525

DOI: 10.1126/science.1135344

PubMed ID: 23562159

Title: A network of high-mobility group box transcription factors programs innate interleukin-17 production.

PubMed ID: 23562159

DOI: 10.1016/j.immuni.2013.01.010

PubMed ID: 27713059

Title: Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.

PubMed ID: 27713059

DOI: 10.1016/j.ydbio.2016.10.001

PubMed ID: 30413363

Title: Interleukin-17-Producing gammadelta T Cells Originate from SOX13+ Progenitors that Are Independent of gammadeltaTCR Signaling.

PubMed ID: 30413363

DOI: 10.1016/j.immuni.2018.09.010

Sequence Information:

Length: 419
Mass: 45465
Checksum: C49C39AE8871C2C0
Sequence:

MPQLDSGGGG AGRGDDLGAP DELLAFQDEG EEQDDKNRDS PVGPERDLAE LKSSLVNESE 
GAAAGAGVPG PGVRVHGEAE GAPEALGREH TSQRLFPDKL PESLEDGLKA PECTSGMYKE 
TVYSAFNLLM PYPPASGAGQ HPQPQPPLHN KPGQPPHGVP QLSPLYEHFS SPHPTPAPAD 
ISQKQGVHRP LQTPDLSGFY SLTSGSMGQL PHTVSWPSPP LYPLSPSCGY RQHFPAPTAA 
PGAPYPRFTH PSLMLGSGVP GHPAAIPHPA IVPSSGKQEL QPYDRNLKTQ AEPKAEKEAK 
KPVIKKPLNA FMLYMKEMRA KVIAECTLKE SAAINQILGR RWHALSREEQ AKYYELARKE 
RQLHMQLYPG WSARDNYGKK KRRSREKHQE STTGGKRNAF GTYPEKAAAP APFLPMTVL

Genular Protein ID: 2611149059

Symbol: Q80UF1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q80UF1

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 303
Mass: 33609
Checksum: 14CC7C3E326EAC92
Sequence:

MYKETVYSAF NLLMPYPPAS GAGQHPQPQP PLHNKPGQPP HGVPQLSPLY EHFSSPHPTP 
APADISQKQG VHRPLQTPDL SGFYSLTSGS MGQLPHTVSW PSPPLYPLSP SCGYRQHFPA 
PTAAPGAPYP RFTHPSLMLG SGVPGHPAAI PHPAIVPSSG KQELQPYDRN LKTQAEPKAE 
KEAKKPVIKK PLNAFMLYMK EMRAKVIAEC TLKESAAINQ ILGRRWHALS REEQAKYYEL 
ARKERQLHMQ LYPGWSARDN YGKKKRRSRE KHQESTTGGK RNAFGTYPEK AAAPAPFLPM 
TVL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tcf7

Associated with

Other Information

Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers. PubMed ID: 1827138

Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. PubMed ID: 8622675

Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. PubMed ID: 10489374

The beta-catenin-TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival. PubMed ID: 11477404

Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. PubMed ID: 17218525

A network of high-mobility group box transcription factors programs innate interleukin-17 production. PubMed ID: 23562159

Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. PubMed ID: 27713059

Interleukin-17-Producing gammadelta T Cells Originate from SOX13+ Progenitors that Are Independent of gammadeltaTCR Signaling. PubMed ID: 30413363

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073