Genular: Defining Cellular Identity and Function

Details for: Zeb1

Gene ID: 21417

Symbol: Zeb1

Ensembl ID: ENSMUSG00000024238

Description: zinc finger E-box binding homeobox 1

Associated with

Anatomical structure development
(GO:0048856)
Animal organ development
(GO:0048513)
Cartilage development
(GO:0051216)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Cellular response to amino acid stimulus
(GO:0071230)
Central nervous system development
(GO:0007417)
Chromatin binding
(GO:0003682)
Cochlea morphogenesis
(GO:0090103)
Cytosol
(GO:0005829)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
E-box binding
(GO:0070888)
Embryonic camera-type eye morphogenesis
(GO:0048596)
Embryonic morphogenesis
(GO:0048598)
Embryonic skeletal system morphogenesis
(GO:0048704)
Epithelial cell proliferation
(GO:0050673)
Keratinocyte proliferation
(GO:0043616)
Metal ion binding
(GO:0046872)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of endothelial cell differentiation
(GO:0045602)
Negative regulation of epithelial cell differentiation
(GO:0030857)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of keratinocyte proliferation
(GO:0010839)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pattern specification process
(GO:0007389)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of mesenchymal cell proliferation
(GO:0010464)
Regulation of smooth muscle cell differentiation
(GO:0051150)
Regulation of t cell differentiation in thymus
(GO:0033081)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Semicircular canal morphogenesis
(GO:0048752)
Sequence-specific dna binding
(GO:0043565)

Other Information

Proteins

Zinc finger homeobox protein 1a

Genular Protein ID: 2215047007

Symbol: ZEB1_MOUSE

Name: Zinc finger homeobox protein 1a

UniProtKB Accession Codes:

Q64318 A4QPD2 Q62519

Database IDs:

Citations:

PubMed ID: 8964504

Title: Organization of the gene encoding transcriptional repressor deltaEF1 and cross-species conservation of its domains.

PubMed ID: 8964504

DOI: 10.1016/0378-1119(96)00185-0

PubMed ID: 8647466

Title: Cloning of a cDNA encoding a mouse transcriptional repressor displaying striking sequence conservation across vertebrates.

PubMed ID: 8647466

DOI: 10.1016/0378-1119(95)00824-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19935649

Title: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

PubMed ID: 19935649

DOI: 10.1038/ncb1998

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20713358

Title: Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells.

PubMed ID: 20713358

DOI: 10.1074/jbc.m110.165027

PubMed ID: 20346398

Title: Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation.

PubMed ID: 20346398

DOI: 10.1016/j.mcn.2010.03.006

Sequence Information:

Length: 1117
Mass: 122465
Checksum: D1FAC2D048D34237
Sequence:

MADGPRCKRR KQANPRRNNV TNYNTVVEAN SDSDDEDKLH IVEEESITDA ADCEGGMPDD 
ELPADQTVLP GGSDRGGGAK NCWQDNVKDN ECDSDAENEQ NHDPNVEEFL QQQDTAVIYP 
EAPEEDQRQG TPEASSHDEN GTPDAFSQLL TCPYCDRGYK RFTSLKEHIK YRHEKNEDNF 
SCSLCSYTFA YRTQLERHMT SHKSGREQRH VTQSGGNRKF KCTECGKAFK YKHHLKEHLR 
IHSGEKPYEC PNCKKRFSHS GSYSSHISSK KCISLMPVNG RPRSGLKTSQ CSSPSLSTSP 
GSPTRPQIRQ KIENKPLQEP LSVNQIKTEP VDYEFKPIVV ASGINCSTPL QNGVFSSGGQ 
LQATSSPQGV VQAVVLPTVG LVSPISINLS DIQNVLKVAV DGNVIRQVLE TNQASLASKE 
QEAVSASPIQ QGGHSVISAI SLPLVDQDGT TKIIINYSLE QPSQLQVVPQ NLKKEIPAPT 
NSCKSEKLPE DLTVKSETDK SFEGARDDST CLLCEDCPGD LNALPELKHY DPECPAQPPP 
PAPATEKPES SASSAGNGDL SPSQPPLKNL LSLLKAYYAL NAQPSTEELS KIADSVNLPL 
DGVKKWFEKM QAGQIPGQSP DPPSPGTGSV NIPTKTDEQP QPADGNEPQE DSTRGQSPVK 
IRSSPVLPVG SAMNGSRSCT SSPSPLNLCS ARNPQGYSCV AEGAQEEPQV EPLDLSLPKQ 
QGELLERSTV SSVYQNSVYS VQEEPLNLSC AKKEPQKDSC VTDSEPVVNV VPPSANPINI 
AIPTVTAQLP TIVAIADQNS VPCLRALAAN KQTILIPQVA YTYSATVSPA VQEPPVKVIQ 
PNGNQDERQD TSSEGVSTVE DQNDSDSTPP KKKTRKTENG MYACDLCDKI FQKSSSLLRH 
KYEHTGKRPH ECGICRKAFK HKHHLIEHMR LHSGEKPYQC DKCGKRFSHS GSYSQHMNHR 
YSYCKRGAED RDAMEQEDAG PEVLPEVLAT EHVGARASPS QADSDERESL TREEDEDSEK 
EEEEEDKEME ELQEGKECEN PQGEEEEEEE EEEEEEEEEE EEVEADEAEH EAAAKTDGTV 
EVGAAQQAGS LEQKASESEM ESESESEQLS EEKTNEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Zeb1

Associated with

Other Information

Organization of the gene encoding transcriptional repressor deltaEF1 and cross-species conservation of its domains. PubMed ID: 8964504

Cloning of a cDNA encoding a mouse transcriptional repressor displaying striking sequence conservation across vertebrates. PubMed ID: 8647466

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. PubMed ID: 19935649

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells. PubMed ID: 20713358

Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation. PubMed ID: 20346398