Details for: Tfap2a

Gene ID: 21418

Symbol: Tfap2a

Ensembl ID: ENSMUSG00000021359

Description: transcription factor AP-2, alpha

Associated with

  • Activation of the tfap2 (ap-2) family of transcription factors
    (R-MMU-8866907)
  • Developmental biology
    (R-MMU-1266738)
  • Gastrulation
    (R-MMU-9758941)
  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Negative regulation of activity of tfap2 (ap-2) family transcription factors
    (R-MMU-8866904)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Specification of the neural plate border
    (R-MMU-9834899)
  • Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation
    (R-MMU-8869496)
  • Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
    (R-MMU-8864260)
  • Anatomical structure development
    (GO:0048856)
  • Anterior neuropore closure
    (GO:0021506)
  • Basement membrane organization
    (GO:0071711)
  • Bone morphogenesis
    (GO:0060349)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to iron ion
    (GO:0071281)
  • Chromatin binding
    (GO:0003682)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Cornea development in camera-type eye
    (GO:0061303)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Embryonic body morphogenesis
    (GO:0010172)
  • Embryonic camera-type eye morphogenesis
    (GO:0048596)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic forelimb morphogenesis
    (GO:0035115)
  • Embryonic pattern specification
    (GO:0009880)
  • Epidermal growth factor receptor signaling pathway
    (GO:0007173)
  • Epidermis morphogenesis
    (GO:0048730)
  • Eyelid development in camera-type eye
    (GO:0061029)
  • Face morphogenesis
    (GO:0060325)
  • Fibroblast migration
    (GO:0010761)
  • Forebrain neuron development
    (GO:0021884)
  • Forelimb morphogenesis
    (GO:0035136)
  • Identical protein binding
    (GO:0042802)
  • Inner ear morphogenesis
    (GO:0042472)
  • Keratinocyte development
    (GO:0003334)
  • Kidney development
    (GO:0001822)
  • Lens induction in camera-type eye
    (GO:0060235)
  • Lens morphogenesis in camera-type eye
    (GO:0002089)
  • Metanephric nephron development
    (GO:0072210)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of epidermal growth factor receptor signaling pathway
    (GO:0042059)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of transcription by competitive promoter binding
    (GO:0010944)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nervous system development
    (GO:0007399)
  • Neural crest cell development
    (GO:0014032)
  • Neural tube closure
    (GO:0001843)
  • Neuron apoptotic process
    (GO:0051402)
  • Nuclear receptor corepressor activity
    (GO:0140536)
  • Oculomotor nerve formation
    (GO:0021623)
  • Optic cup structural organization
    (GO:0003409)
  • Optic vesicle morphogenesis
    (GO:0003404)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Positive regulation of bone mineralization
    (GO:0030501)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of fibroblast migration
    (GO:0010763)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of tooth mineralization
    (GO:0070172)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of neuron differentiation
    (GO:0045664)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Roof of mouth development
    (GO:0060021)
  • Sensory organ development
    (GO:0007423)
  • Sensory perception of sound
    (GO:0007605)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal system morphogenesis
    (GO:0048705)
  • Skin development
    (GO:0043588)
  • Sympathetic nervous system development
    (GO:0048485)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coactivator activity
    (GO:0003713)
  • Transcription corepressor activity
    (GO:0003714)
  • Trigeminal nerve development
    (GO:0021559)

Other Information

Genular Protein ID: 3044738965

Symbol: AP2A_MOUSE

Name: Transcription factor AP-2-alpha

UniProtKB Accession Codes:

P34056 Q60740 Q60741 Q60742 Q60743 Q62067 Q62068 Q62069 Q91VX0 Q9CRY4

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 14 GO 82 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SMR 1 STRING 1 TreeFam 1 UCSC 2 UniProtKB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8233835

Title: The complete murine cDNA sequence of the transcription factor AP-2.

PubMed ID: 8233835

DOI: 10.1093/nar/21.20.4844

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7750631

Title: Alternative mRNAs encode multiple isoforms of transcription factor AP-2 during murine embryogenesis.

PubMed ID: 7750631

DOI: 10.1006/dbio.1995.1121

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 1989904

Title: Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.

PubMed ID: 1989904

DOI: 10.1101/gad.5.1.105

PubMed ID: 12504852

Title: Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells.

PubMed ID: 12504852

DOI: 10.1006/geno.2002.7005

PubMed ID: 15475956

Title: Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.

PubMed ID: 15475956

DOI: 10.1038/ng1446

Sequence Information:

  • Length: 437
  • Mass: 47971
  • Checksum: 901F456EE07AE69C
  • Sequence:
    • MLWKLTDNIK YEDCEDRHDG TSNGTARLPQ LGTVGQSPYT SAPPLSHTPN ADFQPPYFPP 
PYQPIYPQSQ DPYSHVNDPY SLNPLHAQPQ PQHPGWPGQR QSQESGLLHT HRGLPHQLSG 
LDPRRDYRRH EDLLHGPHAL GSGLGDLPIH SLPHAIEDVP HVEDPGINIP DQTVIKKGPV 
SLSKSNSNAV SAIPINKDNL FGGVVNPNEV FCSVPGRLSL LSSTSKYKVT VAEVQRRLSP 
PECLNASLLG GVLRRAKSKN GGRSLREKLD KIGLNLPAGR RKAANVTLLT SLVEGEAVHL 
ARDFGYVCET EFPAKAVAEF LNRQHSDPNE QVARKNMLLA TKQICKEFTD LLAQDRSPLG 
NSRPNPILEP GIQSCLTHFN LISHGFGSPA VCAAVTALQN YLTEALKAMD KMYLSNNPNS 
HTDNSAKSSD KEEKHRK

Genular Protein ID: 2694182496

Symbol: A0A0R4J1E6_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J1E6

Database IDs:

AGR 1 ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 4 GeneTree 1 InterPro 3 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 437
  • Mass: 47957
  • Checksum: FB70628F7E02E3ED
  • Sequence:
    • MLWKLTDNIK YEDCEDRHDG TSNGTARLPQ LGTVGQSPYT SAPPLSHTPN ADFQPPYFPP 
PYQPIYPQSQ DPYSHVNDPY SLNPLHAQPQ PQHPGWPGQR QSQESGLLHT HRGLPHQLSG 
LDPRRDYRRH EDLLHGPHGL GSGLGDLPIH SLPHAIEDVP HVEDPGINIP DQTVIKKGPV 
SLSKSNSNAV SAIPINKDNL FGGVVNPNEV FCSVPGRLSL LSSTSKYKVT VAEVQRRLSP 
PECLNASLLG GVLRRAKSKN GGRSLREKLD KIGLNLPAGR RKAANVTLLT SLVEGEAVHL 
ARDFGYVCET EFPAKAVAEF LNRQHSDPNE QVARKNMLLA TKQICKEFTD LLAQDRSPLG 
NSRPNPILEP GIQSCLTHFN LISHGFGSPA VCAAVTALQN YLTEALKAMD KMYLSNNPNS 
HTDNSAKSSD KEEKHRK

Genular Protein ID: 950117358

Symbol: Q3UL09_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UL09

Database IDs:

AGR 1 ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Genevisible 1 InterPro 3 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 1 UCSC 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 319
  • Mass: 34864
  • Checksum: 7F09E6F6B353604F
  • Sequence:
    • MKMLWKLTDN IKYEDCEDRH DGTSNGTARL PQLGTVGQSP YTSAPPLSHT PNADFQPPYF 
PPPYQPIYPQ SQDPYSHVND PYSLNPLHAQ PQPQHPGWPG QRQSQESGLL HTHRGLPHQL 
SGLDPRRDYR RHEDLLHGPH GLGSGLGDLP IHSLPHAIED VPHVEDPGIN IPDQTVIKKG 
PVSLSKSNSN AVSAIPINKD NLFGGVVNPN EVFCSVPGRL SLLSSTSKYK VTVAEVQRRL 
SPPECLNASL LGGVLRRAKS KNGGRSLREK LDKIGLNLPA GRRKAANVTL LTSLVEGKQI 
CLLSGRELST WGWGGVDNI

Genular Protein ID: 1683969140

Symbol: A0A286YCU0_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A286YCU0

Database IDs:

AGR 1 ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 4 GeneTree 1 InterPro 3 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 433
  • Mass: 47335
  • Checksum: 25DE6A24B6B6EC43
  • Sequence:
    • MSILAKMGDW QDRHDGTSNG TARLPQLGTV GQSPYTSAPP LSHTPNADFQ PPYFPPPYQP 
IYPQSQDPYS HVNDPYSLNP LHAQPQPQHP GWPGQRQSQE SGLLHTHRGL PHQLSGLDPR 
RDYRRHEDLL HGPHGLGSGL GDLPIHSLPH AIEDVPHVED PGINIPDQTV IKKGPVSLSK 
SNSNAVSAIP INKDNLFGGV VNPNEVFCSV PGRLSLLSST SKYKVTVAEV QRRLSPPECL 
NASLLGGVLR RAKSKNGGRS LREKLDKIGL NLPAGRRKAA NVTLLTSLVE GEAVHLARDF 
GYVCETEFPA KAVAEFLNRQ HSDPNEQVAR KNMLLATKQI CKEFTDLLAQ DRSPLGNSRP 
NPILEPGIQS CLTHFNLISH GFGSPAVCAA VTALQNYLTE ALKAMDKMYL SNNPNSHTDN 
SAKSSDKEEK HRK

Genular Protein ID: 354603169

Symbol: A0A286YD43_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A286YD43

Database IDs:

AGR 1 ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 4 GeneTree 1 InterPro 3 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 466
  • Mass: 50886
  • Checksum: 22C9BB5FC65EBDCA
  • Sequence:
    • MNSVVVDTPY FGGLPTLGLW NGFSRVVEAL RLISSSPSRL AFFQDRHDGT SNGTARLPQL 
GTVGQSPYTS APPLSHTPNA DFQPPYFPPP YQPIYPQSQD PYSHVNDPYS LNPLHAQPQP 
QHPGWPGQRQ SQESGLLHTH RGLPHQLSGL DPRRDYRRHE DLLHGPHGLG SGLGDLPIHS 
LPHAIEDVPH VEDPGINIPD QTVIKKGPVS LSKSNSNAVS AIPINKDNLF GGVVNPNEVF 
CSVPGRLSLL SSTSKYKVTV AEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRSLREKLDK 
IGLNLPAGRR KAANVTLLTS LVEGEAVHLA RDFGYVCETE FPAKAVAEFL NRQHSDPNEQ 
VARKNMLLAT KQICKEFTDL LAQDRSPLGN SRPNPILEPG IQSCLTHFNL ISHGFGSPAV 
CAAVTALQNY LTEALKAMDK MYLSNNPNSH TDNSAKSSDK EEKHRK

Genular Protein ID: 99370822

Symbol: Q8BPN4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BPN4

Database IDs:

AGR 1 ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 GeneTree 1 InterPro 3 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 3 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 431
  • Mass: 47078
  • Checksum: 17CCBD6197FB56FD
  • Sequence:
    • MLVHSFSAMD RHDGTSNGTA RLPQLGTVGQ SPYTSAPPLS HTPNADFQPP YFPPPYQPIY 
PQSQDPYSHV NDPYSLNPLH AQPQPQHPGW PGQRQSQESG LLHTHRGLPH QLSGLDPRRD 
YRRHEDLLHG PHGLGSGLGD LPIHSLPHAI EDVPHVEDPG INIPDQTVIK KGPVSLSKSN 
SNAVSAIPIN KDNLFGGVVN PNEVFCSVPG RLSLLSSTSK YKVTVAEVQR RLSPPECLNA 
SLLGGVLRRA KSKNGGRSLR EKLDKIGLNL PAGRRKAANV TLLTSLVEGE AVHLARDFGY 
VCETEFPAKA VAEFLNRQHS DPNEQVARKN MLLATKQICK EFTDLLAQDR SPLGNSRPNP 
ILEPGIQSCL THFNLISHGF GSPAVCAAVT ALQNYLTEAL KAMDKMYLSN NPNSHTDNSA 
KSSDKEEKHR K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.