Details for: Tfec

Gene ID: 21426

Symbol: Tfec

Ensembl ID: ENSMUSG00000029553

Description: transcription factor EC

Associated with

  • Cellular response to heat
    (GO:0034605)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Other Information

Genular Protein ID: 2873922558

Symbol: TFEC_MOUSE

Name: Transcription factor EC

UniProtKB Accession Codes:

Q9WTW4 Q3TWR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10036191

Title: Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members.

PubMed ID: 10036191

DOI: 10.1006/geno.1998.5588

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7958932

Title: microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.

PubMed ID: 7958932

DOI: 10.1101/gad.8.22.2770

PubMed ID: 9973413

Title: TFEC is a macrophage-restricted member of the microphthalmia-TFE subfamily of basic helix-loop-helix leucine zipper transcription factors.

PubMed ID: 9973413

PubMed ID: 11818452

Title: The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.

PubMed ID: 11818452

PubMed ID: 15459106

Title: Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10.

PubMed ID: 15459106

DOI: 10.1242/dev.01300

PubMed ID: 15908341

Title: Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor.

PubMed ID: 15908341

DOI: 10.4049/jimmunol.174.11.7111

Sequence Information:

  • Length: 317
  • Mass: 35144
  • Checksum: 668F186489D63AA8
  • Sequence:
    • MTFDCRVCDQ TLKRAQPPAA SCMPLAEHEP MSPDSDAGCA GNPFTNLLAL GKKDGAEKWH 
LSGSILDVYS DEQGISSANA GLTDAPCPSI LPMRKEIAET DGRALAKERQ KKDNHNLIER 
RRRYNINYRI KELGTLIPKS NDPDMRWNKG TILKASVDYI KWLQKEQQRA RELEHRQKKL 
EHANRQLRLR IQELEIQARA HGLPILASLG TADVGTHITK QQTHPERNLG GCCLQLTPTQ 
GTSPEFYEQA VAFSDPLSHF TDLSFSAALK EEQRLDGMLL SDTICPFGTD PLLSAISPAV 
SKASSRSSLS SEDGDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.