Details for: ALDH1A1

Gene ID: 216

Symbol: ALDH1A1

Ensembl ID: ENSG00000165092

Description: aldehyde dehydrogenase 1 family member A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4
    Marker Score: 5376
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.56
    Marker Score: 3412
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.56
    Marker Score: 4303.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.4
    Marker Score: 29534
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.37
    Marker Score: 2251
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.32
    Marker Score: 2598
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.24
    Marker Score: 24137
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.13
    Marker Score: 10252
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.02
    Marker Score: 5517
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.93
    Marker Score: 10073
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.86
    Marker Score: 7656
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.83
    Marker Score: 1509
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.8
    Marker Score: 17853
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.75
    Marker Score: 1026
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.71
    Marker Score: 4490
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.7
    Marker Score: 9585
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.7
    Marker Score: 2882
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.63
    Marker Score: 6645
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.6
    Marker Score: 2737
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.53
    Marker Score: 7223.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.51
    Marker Score: 21214
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.51
    Marker Score: 10805
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.49
    Marker Score: 86205
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.48
    Marker Score: 5636
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.43
    Marker Score: 4622
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.39
    Marker Score: 1235
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.36
    Marker Score: 5560
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.36
    Marker Score: 682
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.32
    Marker Score: 2896
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.32
    Marker Score: 2003
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.28
    Marker Score: 1127
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.26
    Marker Score: 6691.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.24
    Marker Score: 1311
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.23
    Marker Score: 25170
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.21
    Marker Score: 925
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.21
    Marker Score: 890
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.17
    Marker Score: 2538.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.17
    Marker Score: 9091
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.09
    Marker Score: 5475
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.03
    Marker Score: 5838.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.99
    Marker Score: 2567.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.98
    Marker Score: 2056
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.97
    Marker Score: 922
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.96
    Marker Score: 4147
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.95
    Marker Score: 674
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.93
    Marker Score: 1676
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.9
    Marker Score: 9142
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.89
    Marker Score: 48385
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.86
    Marker Score: 1589
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.85
    Marker Score: 11000.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.81
    Marker Score: 1190
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.8
    Marker Score: 2552
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.8
    Marker Score: 855
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.8
    Marker Score: 1602
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.77
    Marker Score: 407
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.75
    Marker Score: 1681
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.71
    Marker Score: 385
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.69
    Marker Score: 636
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.68
    Marker Score: 417
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.64
    Marker Score: 35009
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.63
    Marker Score: 1799
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.63
    Marker Score: 10456
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 1.62
    Marker Score: 913
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.6
    Marker Score: 408
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.59
    Marker Score: 504
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.57
    Marker Score: 1589
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.54
    Marker Score: 1103
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.52
    Marker Score: 20080
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.52
    Marker Score: 788
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.52
    Marker Score: 15658
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.52
    Marker Score: 3598.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.48
    Marker Score: 2283
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.48
    Marker Score: 1045
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.46
    Marker Score: 1370
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166814
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.45
    Marker Score: 912
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.45
    Marker Score: 465
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.45
    Marker Score: 3300
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.44
    Marker Score: 500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.44
    Marker Score: 1200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.41
    Marker Score: 1657
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.39
    Marker Score: 1722
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.38
    Marker Score: 3261
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.37
    Marker Score: 1434
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.37
    Marker Score: 7361
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.37
    Marker Score: 5896
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.35
    Marker Score: 328
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.35
    Marker Score: 1431
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.32
    Marker Score: 628
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.32
    Marker Score: 527
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.32
    Marker Score: 2676
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.31
    Marker Score: 359
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.31
    Marker Score: 1403
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.29
    Marker Score: 253
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 1.28
    Marker Score: 358
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.27
    Marker Score: 481
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.27
    Marker Score: 298
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.27
    Marker Score: 1344
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.26
    Marker Score: 11101
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.26
    Marker Score: 475

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Other Information

**Key characteristics:** * ALDH1A1 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including the anterior lens cell, retina horizontal cell, lens epithelial cell, ciliated columnar cell of the tracheobronchial tree, nasal mucosa goblet cell, thyroid follicular cell, basal cell of epithelium of trachea, hepatoblast, secretory cell, and ciliated cell. * It is a highly conserved protein, with a high degree of sequence homology observed among different species. **Pathways and functions:** * ALDH1A1 is involved in multiple metabolic pathways, including the metabolism of aldehydes, amino acids, carbohydrates, and lipids. * It plays a role in the detoxification of various chemicals, including acetaldehyde, benzoquinone, and 2-oxoglutarate. * It is also involved in the regulation of cell signaling pathways, through the activation of nuclear receptors. * ALDH1A1 is also involved in the regulation of retinal development and function. **Clinical significance:** * Mutations in ALDH1A1 have been linked to several human diseases, including aldehydes, amino acid, and lipid disorders. * These disorders can lead to a variety of clinical symptoms, including liver damage, neurological problems, and cancer. * Therefore, ALDH1A1 is an important target for the treatment of these diseases. **Additional notes:** * ALDH1A1 is a highly regulated protein, with its expression being controlled by a variety of factors, including growth factors, hormones, and environmental cues. * It is also a substrate for a number of signaling molecules, including retinoic acid and the growth factor receptor EGFR. * ALDH1A1 is a promising target for the treatment of cancer and other diseases that are characterized by abnormal metabolism.

Genular Protein ID: 2942757979

Symbol: AL1A1_HUMAN

Name: ALDH-E1

UniProtKB Accession Codes:

P00352 O00768 Q5SYR1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 85 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 5 EMBL 22 EMDB 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 22 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 28 PDBsum 20 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 3 RefSeq 1 Rhea 26 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UniPathway 1 UniProtKB 6 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2591967

Title: Genomic structure of the human cytosolic aldehyde dehydrogenase gene.

PubMed ID: 2591967

DOI: 10.1016/0888-7543(89)90127-4

PubMed ID: 8214422

Title: Cloning and expression of the full-length cDNAs encoding human liver class 1 and class 2 aldehyde dehydrogenase.

PubMed ID: 8214422

DOI: 10.1111/j.1530-0277.1993.tb00849.x

PubMed ID: 19296407

Title: Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydes.

PubMed ID: 19296407

DOI: 10.1080/15287390802706371

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8493914

Title: Biological role of human cytosolic aldehyde dehydrogenase 1: hormonal response, retinal oxidation and implication in testicular feminization.

PubMed ID: 8493914

DOI: 10.1007/978-1-4615-2904-0_5

PubMed ID: 6723659

Title: Aldehyde dehydrogenase from human liver. Primary structure of the cytoplasmic isoenzyme.

PubMed ID: 6723659

DOI: 10.1111/j.1432-1033.1984.tb08150.x

PubMed ID: 4015823

Title: Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases.

PubMed ID: 4015823

DOI: 10.1016/0741-8329(85)90024-2

PubMed ID: 2987944

Title: Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2.

PubMed ID: 2987944

DOI: 10.1073/pnas.82.11.3771

PubMed ID: 3676276

Title: Active site of human liver aldehyde dehydrogenase.

PubMed ID: 3676276

DOI: 10.1021/bi00392a015

PubMed ID: 2776714

Title: Aldehyde dehydrogenase from human erythrocytes: structural relationship to the liver cytosolic isozyme.

PubMed ID: 2776714

DOI: 10.1159/000469006

PubMed ID: 12941160

Title: Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA.

PubMed ID: 12941160

DOI: 10.1089/104454903322216671

PubMed ID: 15623782

Title: Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress.

PubMed ID: 15623782

DOI: 10.1167/iovs.04-0120

PubMed ID: 17175089

Title: Identification of 3-deoxyglucosone dehydrogenase as aldehyde dehydrogenase 1A1 (retinaldehyde dehydrogenase 1).

PubMed ID: 17175089

DOI: 10.1016/j.biochi.2006.11.005

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33495566

Title: PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling.

PubMed ID: 33495566

DOI: 10.1038/s42003-020-01644-3

PubMed ID: 26373694

Title: Structural, biochemical, and computational studies reveal the mechanism of selective aldehyde dehydrogenase 1A1 inhibition by cytotoxic duocarmycin analogues.

PubMed ID: 26373694

DOI: 10.1002/anie.201505749

PubMed ID: 25450233

Title: Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.

PubMed ID: 25450233

DOI: 10.1016/j.cbi.2014.10.028

PubMed ID: 25634381

Title: Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.

PubMed ID: 25634381

DOI: 10.1021/jm501900s

Sequence Information:

  • Length: 501
  • Mass: 54862
  • Checksum: B26464DC7168348E
  • Sequence:
    • MSSSGTPDLP VLLTDLKIQY TKIFINNEWH DSVSGKKFPV FNPATEEELC QVEEGDKEDV 
DKAVKAARQA FQIGSPWRTM DASERGRLLY KLADLIERDR LLLATMESMN GGKLYSNAYL 
NDLAGCIKTL RYCAGWADKI QGRTIPIDGN FFTYTRHEPI GVCGQIIPWN FPLVMLIWKI 
GPALSCGNTV VVKPAEQTPL TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDID 
KVAFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVLA DADLDNAVEF AHHGVFYHQG 
QCCIAASRIF VEESIYDEFV RRSVERAKKY ILGNPLTPGV TQGPQIDKEQ YDKILDLIES 
GKKEGAKLEC GGGPWGNKGY FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSLDDVIKR 
ANNTFYGLSA GVFTKDIDKA ITISSALQAG TVWVNCYGVV SAQCPFGGFK MSGNGRELGE 
YGFHEYTEVK TVTVKISQKN S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.