ALDH1A1 | ENSG00000165092 | NCBI 216

Details for: ALDH1A1

Gene ID: 216

Symbol: ALDH1A1

Ensembl ID: ENSG00000165092

Description: aldehyde dehydrogenase 1 family member A1

Associated with

Biological oxidations
(R-HSA-211859)
Ethanol oxidation
(R-HSA-71384)
Fructose catabolism
(R-HSA-70350)
Fructose metabolism
(R-HSA-5652084)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Phase i - functionalization of compounds
(R-HSA-211945)
Ra biosynthesis pathway
(R-HSA-5365859)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by retinoic acid
(R-HSA-5362517)
Signal transduction
(R-HSA-162582)
3-deoxyglucosone dehydrogenase activity
(GO:0106373)
Aldehyde dehydrogenase (nad+) activity
(GO:0004029)
Aminobutyraldehyde dehydrogenase activity
(GO:0019145)
Androgen binding
(GO:0005497)
Axon
(GO:0030424)
Benzaldehyde dehydrogenase (nad+) activity
(GO:0018479)
Cellular aldehyde metabolic process
(GO:0006081)
Cellular detoxification of aldehyde
(GO:0110095)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Fructosamine catabolic process
(GO:0030392)
Gamma-aminobutyric acid biosynthetic process
(GO:0009449)
Glyceraldehyde-3-phosphate dehydrogenase (nad+) (non-phosphorylating) activity
(GO:0043878)
Gtpase activator activity
(GO:0005096)
Maintenance of lens transparency
(GO:0036438)
Nad binding
(GO:0051287)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Protein binding
(GO:0005515)
Retinal dehydrogenase activity
(GO:0001758)
Retinoid metabolic process
(GO:0001523)
Retinol metabolic process
(GO:0042572)
Synapse
(GO:0045202)

Other Information

Proteins

ALDH-E1

Genular Protein ID: 2942757979

Symbol: AL1A1_HUMAN

Name: ALDH-E1

UniProtKB Accession Codes:

P00352 O00768 Q5SYR1

Database IDs:

Citations:

PubMed ID: 2591967

Title: Genomic structure of the human cytosolic aldehyde dehydrogenase gene.

PubMed ID: 2591967

DOI: 10.1016/0888-7543(89)90127-4

PubMed ID: 8214422

Title: Cloning and expression of the full-length cDNAs encoding human liver class 1 and class 2 aldehyde dehydrogenase.

PubMed ID: 8214422

DOI: 10.1111/j.1530-0277.1993.tb00849.x

PubMed ID: 19296407

Title: Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydes.

PubMed ID: 19296407

DOI: 10.1080/15287390802706371

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8493914

Title: Biological role of human cytosolic aldehyde dehydrogenase 1: hormonal response, retinal oxidation and implication in testicular feminization.

PubMed ID: 8493914

DOI: 10.1007/978-1-4615-2904-0_5

PubMed ID: 6723659

Title: Aldehyde dehydrogenase from human liver. Primary structure of the cytoplasmic isoenzyme.

PubMed ID: 6723659

DOI: 10.1111/j.1432-1033.1984.tb08150.x

PubMed ID: 4015823

Title: Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases.

PubMed ID: 4015823

DOI: 10.1016/0741-8329(85)90024-2

PubMed ID: 2987944

Title: Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2.

PubMed ID: 2987944

DOI: 10.1073/pnas.82.11.3771

PubMed ID: 3676276

Title: Active site of human liver aldehyde dehydrogenase.

PubMed ID: 3676276

DOI: 10.1021/bi00392a015

PubMed ID: 2776714

Title: Aldehyde dehydrogenase from human erythrocytes: structural relationship to the liver cytosolic isozyme.

PubMed ID: 2776714

DOI: 10.1159/000469006

PubMed ID: 12941160

Title: Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA.

PubMed ID: 12941160

DOI: 10.1089/104454903322216671

PubMed ID: 15623782

Title: Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress.

PubMed ID: 15623782

DOI: 10.1167/iovs.04-0120

PubMed ID: 17175089

Title: Identification of 3-deoxyglucosone dehydrogenase as aldehyde dehydrogenase 1A1 (retinaldehyde dehydrogenase 1).

PubMed ID: 17175089

DOI: 10.1016/j.biochi.2006.11.005

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33495566

Title: PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling.

PubMed ID: 33495566

DOI: 10.1038/s42003-020-01644-3

PubMed ID: 26373694

Title: Structural, biochemical, and computational studies reveal the mechanism of selective aldehyde dehydrogenase 1A1 inhibition by cytotoxic duocarmycin analogues.

PubMed ID: 26373694

DOI: 10.1002/anie.201505749

PubMed ID: 25450233

Title: Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.

PubMed ID: 25450233

DOI: 10.1016/j.cbi.2014.10.028

PubMed ID: 25634381

Title: Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.

PubMed ID: 25634381

DOI: 10.1021/jm501900s

Sequence Information:

Length: 501
Mass: 54862
Checksum: B26464DC7168348E
Sequence:

MSSSGTPDLP VLLTDLKIQY TKIFINNEWH DSVSGKKFPV FNPATEEELC QVEEGDKEDV 
DKAVKAARQA FQIGSPWRTM DASERGRLLY KLADLIERDR LLLATMESMN GGKLYSNAYL 
NDLAGCIKTL RYCAGWADKI QGRTIPIDGN FFTYTRHEPI GVCGQIIPWN FPLVMLIWKI 
GPALSCGNTV VVKPAEQTPL TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDID 
KVAFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVLA DADLDNAVEF AHHGVFYHQG 
QCCIAASRIF VEESIYDEFV RRSVERAKKY ILGNPLTPGV TQGPQIDKEQ YDKILDLIES 
GKKEGAKLEC GGGPWGNKGY FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSLDDVIKR 
ANNTFYGLSA GVFTKDIDKA ITISSALQAG TVWVNCYGVV SAQCPFGGFK MSGNGRELGE 
YGFHEYTEVK TVTVKISQKN S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ALDH1A1

Associated with

Other Information

Genomic structure of the human cytosolic aldehyde dehydrogenase gene. PubMed ID: 2591967

Cloning and expression of the full-length cDNAs encoding human liver class 1 and class 2 aldehyde dehydrogenase. PubMed ID: 8214422

Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydes. PubMed ID: 19296407

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Biological role of human cytosolic aldehyde dehydrogenase 1: hormonal response, retinal oxidation and implication in testicular feminization. PubMed ID: 8493914

Aldehyde dehydrogenase from human liver. Primary structure of the cytoplasmic isoenzyme. PubMed ID: 6723659

Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases. PubMed ID: 4015823

Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. PubMed ID: 2987944

Active site of human liver aldehyde dehydrogenase. PubMed ID: 3676276

Aldehyde dehydrogenase from human erythrocytes: structural relationship to the liver cytosolic isozyme. PubMed ID: 2776714

Molecular cloning and baculovirus expression of the rabbit corneal aldehyde dehydrogenase (ALDH1A1) cDNA. PubMed ID: 12941160

Role of aldehyde dehydrogenase isozymes in the defense of rat lens and human lens epithelial cells against oxidative stress. PubMed ID: 15623782

Identification of 3-deoxyglucosone dehydrogenase as aldehyde dehydrogenase 1A1 (retinaldehyde dehydrogenase 1). PubMed ID: 17175089

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling. PubMed ID: 33495566

Structural, biochemical, and computational studies reveal the mechanism of selective aldehyde dehydrogenase 1A1 inhibition by cytotoxic duocarmycin analogues. PubMed ID: 26373694

Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. PubMed ID: 25450233

Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. PubMed ID: 25634381