Genular: Defining Cellular Identity and Function

Details for: Tdg

Gene ID: 21665

Symbol: Tdg

Ensembl ID: ENSMUSG00000034674

Description: thymine DNA glycosylase

Associated with

Base excision repair
(R-MMU-73884)
Cleavage of the damaged pyrimidine
(R-MMU-110329)
Depyrimidination
(R-MMU-73928)
Displacement of dna glycosylase by apex1
(R-MMU-110357)
Gene expression (transcription)
(R-MMU-74160)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Resolution of abasic sites (ap sites)
(R-MMU-73933)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of dna damage response and repair proteins
(R-MMU-3108214)
Tet1,2,3 and tdg demethylate dna
(R-MMU-5221030)
Atp binding
(GO:0005524)
Base-excision repair
(GO:0006284)
Base-excision repair, ap site formation
(GO:0006285)
Chloride ion binding
(GO:0031404)
Chromatin organization
(GO:0006325)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna n-glycosylase activity
(GO:0019104)
Dna repair
(GO:0006281)
Double-stranded dna binding
(GO:0003690)
Epigenetic regulation of gene expression
(GO:0040029)
G/t mismatch-specific thymine-dna glycosylase activity
(GO:0141016)
G/u mismatch-specific uracil-dna glycosylase activity
(GO:0043739)
Hydrolase activity
(GO:0016787)
Magnesium ion binding
(GO:0000287)
Mismatch base pair dna n-glycosylase activity
(GO:0000700)
Mismatched dna binding
(GO:0030983)
Negative regulation of chromatin binding
(GO:0035562)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Pml body
(GO:0016605)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase c binding
(GO:0005080)
Protein self-association
(GO:0043621)
Pyrimidine-specific mismatch base pair dna n-glycosylase activity
(GO:0008263)
Regulation of embryonic development
(GO:0045995)
Sodium ion binding
(GO:0031402)
Sumo binding
(GO:0032183)
Transcription coregulator activity
(GO:0003712)
Uracil dna n-glycosylase activity
(GO:0004844)

Other Information

Proteins

G/T mismatch-specific thymine DNA glycosylase

Genular Protein ID: 962960378

Symbol: TDG_MOUSE

Name: G/T mismatch-specific thymine DNA glycosylase

UniProtKB Accession Codes:

P56581 Q3TPW4 Q542A9 Q5U3M4 Q5U3M5 Q6PJW4 Q8BPK0

Database IDs:

Citations:

PubMed ID: 9694815

Title: Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase.

PubMed ID: 9694815

DOI: 10.1074/jbc.273.33.20728

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1631061

Title: Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.

PubMed ID: 1631061

DOI: 10.1073/pnas.89.13.5789

PubMed ID: 21722948

Title: Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.

PubMed ID: 21722948

DOI: 10.1016/j.cell.2011.06.020

PubMed ID: 21278727

Title: Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.

PubMed ID: 21278727

DOI: 10.1038/nature09672

PubMed ID: 21817016

Title: Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.

PubMed ID: 21817016

DOI: 10.1126/science.1210944

Sequence Information:

Length: 421
Mass: 46879
Checksum: A91BB0A5911933BC
Sequence:

MDAEAARSYS LEQVQALYSF PFQQMMAEVP NMAVTTGQQV PAVAPNMATV TEQQVPEDAP 
VQEPAPEAPK RRKRKPRAAE PQEPVEPKKP ATSKKSGKST KSKEKQEKIT DAFKVKRKVD 
RFNGVSEAEL LTKTLPDILT FNLDIVIIGI NPGLMAAYKG HHYPGPGNHF WKCLFMSGLS 
EVQLNHMDDH TLPGKYGIGF TNMVERTTPG SKDLSSKEFR EGGRILVQKL QKYQPRIAVF 
NGKCIYEIFS KEVFGVKVKN LEFGLQPHKI PDTETLCYVM PSSSARCAQF PRAQDKVHYY 
IKLKDLRDQL KGIERNADVQ EVQYTFDLQL AQEDAKKMAV KEEKYDPGYE AAYGGAYGEN 
PCNGEPCGIA SNGLTAHSAE PRGEAAPSDV PNGQWMAQSF AEQIPSFNNC GTREQEEESH 
A

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tdg

Associated with

Other Information

Retinoic acid receptors interact physically and functionally with the T:G mismatch-specific thymine-DNA glycosylase. PubMed ID: 9694815

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. PubMed ID: 1631061

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. PubMed ID: 21722948

Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. PubMed ID: 21278727

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. PubMed ID: 21817016