Genular: Defining Cellular Identity and Function

Details for: Alyref

Gene ID: 21681

Symbol: Alyref

Ensembl ID: ENSMUSG00000025134

Description: Aly/REF export factor

Associated with

Gene expression (transcription)
(R-MMU-74160)
Metabolism of rna
(R-MMU-8953854)
Mrna 3'-end processing
(R-MMU-72187)
Mrna splicing
(R-MMU-72172)
Mrna splicing - major pathway
(R-MMU-72163)
Processing of capped intron-containing pre-mrna
(R-MMU-72203)
Rna polymerase ii transcription
(R-MMU-73857)
Rna polymerase ii transcription termination
(R-MMU-73856)
Transport of mature mrna derived from an intron-containing transcript
(R-MMU-159236)
Transport of mature mrna derived from an intronless transcript
(R-MMU-159231)
Transport of mature mrnas derived from intronless transcripts
(R-MMU-159234)
Transport of mature transcript to cytoplasm
(R-MMU-72202)
Transport of the slbp dependant mature mrna
(R-MMU-159230)
Transport of the slbp independent mature mrna
(R-MMU-159227)
C5-methylcytidine-containing rna reader activity
(GO:0062153)
Catalytic step 2 spliceosome
(GO:0071013)
Chromosome, telomeric region
(GO:0000781)
Cytoplasm
(GO:0005737)
Exon-exon junction complex
(GO:0035145)
Molecular adaptor activity
(GO:0060090)
Mrna binding
(GO:0003729)
Mrna export from nucleus
(GO:0006406)
Mrna processing
(GO:0006397)
Mrna transport
(GO:0051028)
Nucleic acid binding
(GO:0003676)
Nucleus
(GO:0005634)
Rna binding
(GO:0003723)
Rna export from nucleus
(GO:0006405)
Rna folding chaperone
(GO:0140691)
Rna splicing
(GO:0008380)
Single-stranded dna binding
(GO:0003697)
Spliceosomal complex
(GO:0005681)
Transcription export complex
(GO:0000346)

Other Information

Proteins

THO complex subunit 4

Genular Protein ID: 3008829521

Symbol: THOC4_MOUSE

Name: THO complex subunit 4

UniProtKB Accession Codes:

O08583 Q0VBL5 Q8CBM4 Q9JJW7

Database IDs:

Citations:

PubMed ID: 9119228

Title: ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.

PubMed ID: 9119228

DOI: 10.1101/gad.11.5.640

PubMed ID: 10786854

Title: REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export.

PubMed ID: 10786854

DOI: 10.1017/s1355838200000078

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11158589

Title: REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus.

PubMed ID: 11158589

DOI: 10.1073/pnas.98.3.1030

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24463520

Title: Citrullination regulates pluripotency and histone H1 binding to chromatin.

PubMed ID: 24463520

DOI: 10.1038/nature12942

PubMed ID: 12809490

Title: Structure of the nuclear factor ALY: insights into post-transcriptional regulatory and mRNA nuclear export processes.

PubMed ID: 12809490

DOI: 10.1021/bi034062o

Sequence Information:

Length: 255
Mass: 26940
Checksum: F597235EBDD47C17
Sequence:

MADKMDMSLD DIIKLNRSQR GGRGGGRGRG RAGSQGGRGG AVQAAARVNR GGGPMRNRPA 
IARGAAGGGR NRPAPYSRPK QLPDKWQHDL FDSGFGGGAG VETGGKLLVS NLDFGVSDAD 
IQELFAEFGT LKKAAVHYDR SGRSLGTADV HFERKADALK AMKQYNGVPL DGRPMNIQLV 
TSQIDTQRRP AQSINRGGMT RNRGSGGFGG GGTRRGTRGG SRGRGRGTGR NSKQQLSAEE 
LDAQLDAYNA RMDTS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Alyref

Associated with

Other Information

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. PubMed ID: 9119228

REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. PubMed ID: 10786854

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus. PubMed ID: 11158589

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Citrullination regulates pluripotency and histone H1 binding to chromatin. PubMed ID: 24463520

Structure of the nuclear factor ALY: insights into post-transcriptional regulatory and mRNA nuclear export processes. PubMed ID: 12809490