ALDH2 | ENSG00000111275 | NCBI 217

Details for: ALDH2

Gene ID: 217

Symbol: ALDH2

Ensembl ID: ENSG00000111275

Description: aldehyde dehydrogenase 2 family member

Associated with

Biological oxidations
(R-HSA-211859)
Ethanol oxidation
(R-HSA-71384)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Metabolism of serotonin
(R-HSA-380612)
Mitochondrial protein degradation
(R-HSA-9837999)
Muscle contraction
(R-HSA-397014)
Neuronal system
(R-HSA-112316)
Neurotransmitter clearance
(R-HSA-112311)
Phase i - functionalization of compounds
(R-HSA-211945)
Serotonin clearance from the synaptic cleft
(R-HSA-380615)
Smooth muscle contraction
(R-HSA-445355)
Transmission across chemical synapses
(R-HSA-112315)
Alcohol metabolic process
(GO:0006066)
Aldehyde catabolic process
(GO:0046185)
Aldehyde dehydrogenase (nad+) activity
(GO:0004029)
Aldehyde dehydrogenase [nad(p)+] activity
(GO:0004030)
Carbohydrate metabolic process
(GO:0005975)
Carboxylesterase activity
(GO:0106435)
Electron transfer activity
(GO:0009055)
Electron transport chain
(GO:0022900)
Ethanol catabolic process
(GO:0006068)
Extracellular exosome
(GO:0070062)
Glyceraldehyde-3-phosphate dehydrogenase (nad+) (non-phosphorylating) activity
(GO:0043878)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Nad binding
(GO:0051287)
Nitroglycerin reductase activity
(GO:0018547)
Phenylacetaldehyde dehydrogenase activity
(GO:0008957)
Regulation of dopamine biosynthetic process
(GO:1903179)
Regulation of serotonin biosynthetic process
(GO:1905627)

Other Information

Proteins

Aldehyde dehydrogenase, mitochondrial

Genular Protein ID: 1184527

Symbol: ALDH2_HUMAN

Name: Aldehyde dehydrogenase, mitochondrial

UniProtKB Accession Codes:

P05091 B4DW54 E7EUE5 Q03639 Q6IB13 Q6IV71

Database IDs:

Citations:

PubMed ID: 3582651

Title: Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase.

PubMed ID: 3582651

DOI: 10.1016/0014-5793(87)80152-7

PubMed ID: 3562250

Title: Isolation and sequence analysis of a full length cDNA clone coding for human mitochondrial aldehyde dehydrogenase.

PubMed ID: 3562250

DOI: 10.1093/nar/15.7.3179

PubMed ID: 2838413

Title: Genomic structure of the human mitochondrial aldehyde dehydrogenase gene.

PubMed ID: 2838413

DOI: 10.1016/0888-7543(88)90109-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4065146

Title: Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations.

PubMed ID: 4065146

DOI: 10.1111/j.1432-1033.1985.tb09260.x

PubMed ID: 2987944

Title: Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2.

PubMed ID: 2987944

DOI: 10.1073/pnas.82.11.3771

PubMed ID: 4015823

Title: Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases.

PubMed ID: 4015823

DOI: 10.1016/0741-8329(85)90024-2

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 3610592

Title: Human aldehyde dehydrogenase isozymes and alcohol sensitivity.

PubMed ID: 3610592

PubMed ID: 3653404

Title: Mitochondrial aldehyde dehydrogenase. Homology of putative targeting sequence to that of carbamyl phosphate synthetase I revealed by correlation of cDNA and protein data.

PubMed ID: 3653404

DOI: 10.1016/0014-5793(87)80198-9

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10631996

Title: Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms.

PubMed ID: 10631996

DOI: 10.1110/ps.8.12.2784

PubMed ID: 6582480

Title: Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals.

PubMed ID: 6582480

DOI: 10.1073/pnas.81.1.258

PubMed ID: 8561277

Title: Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles.

PubMed ID: 8561277

DOI: 10.1111/j.1530-0277.1995.tb01587.x

PubMed ID: 33355142

Title: Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.

PubMed ID: 33355142

DOI: 10.1126/sciadv.abd7197

Sequence Information:

Length: 517
Mass: 56381
Checksum: E8F74D44D285A00E
Sequence:

MLRAAARFGP RLGRRLLSAA ATQAVPAPNQ QPEVFCNQIF INNEWHDAVS RKTFPTVNPS 
TGEVICQVAE GDKEDVDKAV KAARAAFQLG SPWRRMDASH RGRLLNRLAD LIERDRTYLA 
ALETLDNGKP YVISYLVDLD MVLKCLRYYA GWADKYHGKT IPIDGDFFSY TRHEPVGVCG 
QIIPWNFPLL MQAWKLGPAL ATGNVVVMKV AEQTPLTALY VANLIKEAGF PPGVVNIVPG 
FGPTAGAAIA SHEDVDKVAF TGSTEIGRVI QVAAGSSNLK RVTLELGGKS PNIIMSDADM 
DWAVEQAHFA LFFNQGQCCC AGSRTFVQED IYDEFVERSV ARAKSRVVGN PFDSKTEQGP 
QVDETQFKKI LGYINTGKQE GAKLLCGGGI AADRGYFIQP TVFGDVQDGM TIAKEEIFGP 
VMQILKFKTI EEVVGRANNS TYGLAAAVFT KDLDKANYLS QALQAGTVWV NCYDVFGAQS 
PFGGYKMSGS GRELGEYGLQ AYTEVKTVTV KVPQKNS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ALDH2

Associated with

Other Information

Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase. PubMed ID: 3582651

Isolation and sequence analysis of a full length cDNA clone coding for human mitochondrial aldehyde dehydrogenase. PubMed ID: 3562250

Genomic structure of the human mitochondrial aldehyde dehydrogenase gene. PubMed ID: 2838413

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. PubMed ID: 4065146

Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. PubMed ID: 2987944

Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases. PubMed ID: 4015823

Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. PubMed ID: 15242332

Human aldehyde dehydrogenase isozymes and alcohol sensitivity. PubMed ID: 3610592

Mitochondrial aldehyde dehydrogenase. Homology of putative targeting sequence to that of carbamyl phosphate synthetase I revealed by correlation of cDNA and protein data. PubMed ID: 3653404

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms. PubMed ID: 10631996

Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. PubMed ID: 6582480

Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles. PubMed ID: 8561277

Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome. PubMed ID: 33355142