Genular: Defining Cellular Identity and Function

Details for: Tert

Gene ID: 21752

Symbol: Tert

Ensembl ID: ENSMUSG00000021611

Description: telomerase reverse transcriptase

Associated with

Cell cycle
(R-MMU-1640170)
Chromosome maintenance
(R-MMU-73886)
Extension of telomeres
(R-MMU-180786)
Formation of the beta-catenin:tcf transactivating complex
(R-MMU-201722)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Telomere extension by telomerase
(R-MMU-171319)
Telomere maintenance
(R-MMU-157579)
Cellular response to hypoxia
(GO:0071456)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Dna biosynthetic process
(GO:0071897)
Dna strand elongation
(GO:0022616)
Establishment of protein localization to telomere
(GO:0070200)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Mitochondrial nucleoid
(GO:0042645)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glial cell proliferation
(GO:0060253)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nuclear speck
(GO:0016607)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotidyltransferase activity
(GO:0016779)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Pml body
(GO:0016605)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of hair cycle
(GO:0042635)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of nitric-oxide synthase activity
(GO:0051000)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein localization to nucleolus
(GO:1904751)
Positive regulation of stem cell proliferation
(GO:2000648)
Positive regulation of transdifferentiation
(GO:1903620)
Positive regulation of vascular associated smooth muscle cell migration
(GO:1904754)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Positive regulation of wnt signaling pathway
(GO:0030177)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of protein stability
(GO:0031647)
Replicative senescence
(GO:0090399)
Ribonucleoprotein complex
(GO:1990904)
Rna-dependent rna polymerase activity
(GO:0003968)
Rna-directed dna polymerase activity
(GO:0003964)
Rna-directed rna polymerase complex
(GO:0031379)
Rna-templated dna biosynthetic process
(GO:0006278)
Rna-templated transcription
(GO:0001172)
Rna binding
(GO:0003723)
Sirna processing
(GO:0030422)
Sirna transcription
(GO:0140745)
Telomerase activity
(GO:0003720)
Telomerase catalytic core complex
(GO:0000333)
Telomerase holoenzyme complex
(GO:0005697)
Telomerase rna binding
(GO:0070034)
Telomerase rna reverse transcriptase activity
(GO:0003721)
Telomere maintenance via telomerase
(GO:0007004)
Telomeric dna binding
(GO:0042162)
Template-free rna nucleotidyltransferase
(GO:0098680)
Tert-rmrp complex
(GO:1990572)
Transcription coactivator binding
(GO:0001223)
Transferase activity
(GO:0016740)
Trna binding
(GO:0000049)

Other Information

Proteins

Telomerase reverse transcriptase

Genular Protein ID: 3722565485

Symbol: TERT_MOUSE

Name: Telomerase reverse transcriptase

UniProtKB Accession Codes:

O70372 O35432 Q9JK99

Database IDs:

Citations:

PubMed ID: 9582020

Title: Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation.

PubMed ID: 9582020

DOI: 10.1038/sj.onc.1201933

PubMed ID: 9724727

Title: Expression of mouse telomerase catalytic subunit in embryos and adult tissues.

PubMed ID: 9724727

DOI: 10.1073/pnas.95.18.10471

PubMed ID: 13679242

Title: Cloning of rat telomerase catalytic subunit functional domains, reconstitution of telomerase activity and enzymatic profile of pig and chicken tissues.

PubMed ID: 13679242

DOI: 10.1016/s0024-3205(03)00670-2

PubMed ID: 17130244

Title: Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo.

PubMed ID: 17130244

DOI: 10.1128/mcb.01866-06

PubMed ID: 19487455

Title: GNL3L stabilizes the TRF1 complex and promotes mitotic transition.

PubMed ID: 19487455

DOI: 10.1083/jcb.200812121

PubMed ID: 19571879

Title: Telomerase modulates Wnt signalling by association with target gene chromatin.

PubMed ID: 19571879

DOI: 10.1038/nature08137

Sequence Information:

Length: 1122
Mass: 127978
Checksum: F85266905DD6558C
Sequence:

MTRAPRCPAV RSLLRSRYRE VWPLATFVRR LGPEGRRLVQ PGDPKIYRTL VAQCLVCMHW 
GSQPPPADLS FHQVSSLKEL VARVVQRLCE RNERNVLAFG FELLNEARGG PPMAFTSSVR 
SYLPNTVIET LRVSGAWMLL LSRVGDDLLV YLLAHCALYL LVPPSCAYQV CGSPLYQICA 
TTDIWPSVSA SYRPTRPVGR NFTNLRFLQQ IKSSSRQEAP KPLALPSRGT KRHLSLTSTS 
VPSAKKARCY PVPRVEEGPH RQVLPTPSGK SWVPSPARSP EVPTAEKDLS SKGKVSDLSL 
SGSVCCKHKP SSTSLLSPPR QNAFQLRPFI ETRHFLYSRG DGQERLNPSF LLSNLQPNLT 
GARRLVEIIF LGSRPRTSGP LCRTHRLSRR YWQMRPLFQQ LLVNHAECQY VRLLRSHCRF 
RTANQQVTDA LNTSPPHLMD LLRLHSSPWQ VYGFLRACLC KVVSASLWGT RHNERRFFKN 
LKKFISLGKY GKLSLQELMW KMKVEDCHWL RSSPGKDRVP AAEHRLRERI LATFLFWLMD 
TYVVQLLRSF FYITESTFQK NRLFFYRKSV WSKLQSIGVR QHLERVRLRE LSQEEVRHHQ 
DTWLAMPICR LRFIPKPNGL RPIVNMSYSM GTRALGRRKQ AQHFTQRLKT LFSMLNYERT 
KHPHLMGSSV LGMNDIYRTW RAFVLRVRAL DQTPRMYFVK ADVTGAYDAI PQGKLVEVVA 
NMIRHSESTY CIRQYAVVRR DSQGQVHKSF RRQVTTLSDL QPYMGQFLKH LQDSDASALR 
NSVVIEQSIS MNESSSSLFD FFLHFLRHSV VKIGDRCYTQ CQGIPQGSSL STLLCSLCFG 
DMENKLFAEV QRDGLLLRFV DDFLLVTPHL DQAKTFLSTL VHGVPEYGCM INLQKTVVNF 
PVEPGTLGGA APYQLPAHCL FPWCGLLLDT QTLEVFCDYS GYAQTSIKTS LTFQSVFKAG 
KTMRNKLLSV LRLKCHGLFL DLQVNSLQTV CINIYKIFLL QAYRFHACVI QLPFDQRVRK 
NLTFFLGIIS SQASCCYAIL KVKNPGMTLK ASGSFPPEAA HWLCYQAFLL KLAAHSVIYK 
CLLGPLRTAQ KLLCRKLPEA TMTILKAAAD PALSTDFQTI LD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tert

Associated with

Other Information

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. PubMed ID: 9582020

Expression of mouse telomerase catalytic subunit in embryos and adult tissues. PubMed ID: 9724727

Cloning of rat telomerase catalytic subunit functional domains, reconstitution of telomerase activity and enzymatic profile of pig and chicken tissues. PubMed ID: 13679242

Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. PubMed ID: 17130244

GNL3L stabilizes the TRF1 complex and promotes mitotic transition. PubMed ID: 19487455