Details for: ALDH3A1

Gene ID: 218

Symbol: ALDH3A1

Ensembl ID: ENSG00000108602

Description: aldehyde dehydrogenase 3 family member A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.11
    Marker Score: 23156
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.94
    Marker Score: 18776
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.92
    Marker Score: 1950
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.72
    Marker Score: 2866
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.71
    Marker Score: 2260
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.68
    Marker Score: 23103
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.42
    Marker Score: 18873
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.41
    Marker Score: 8300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.34
    Marker Score: 20292
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.1
    Marker Score: 4764
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.81
    Marker Score: 3741.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.7
    Marker Score: 795
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.59
    Marker Score: 2052
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.57
    Marker Score: 1735
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.55
    Marker Score: 1759
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.36
    Marker Score: 18230
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.25
    Marker Score: 2381
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.19
    Marker Score: 1061
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.15
    Marker Score: 1341
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.11
    Marker Score: 550
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.1
    Marker Score: 698
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2218
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.96
    Marker Score: 654
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5307
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14549
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.89
    Marker Score: 1619
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.87
    Marker Score: 250
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.84
    Marker Score: 487
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 635
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3328
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.74
    Marker Score: 1404
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.71
    Marker Score: 172
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.69
    Marker Score: 288
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.66
    Marker Score: 604
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.61
    Marker Score: 208
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 387
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 466
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.57
    Marker Score: 350
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.56
    Marker Score: 140
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.5
    Marker Score: 394
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.49
    Marker Score: 218
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.48
    Marker Score: 1128
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.48
    Marker Score: 151
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.46
    Marker Score: 170
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 184.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.44
    Marker Score: 207
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.43
    Marker Score: 1048
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 394
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.39
    Marker Score: 94
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.38
    Marker Score: 173
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.38
    Marker Score: 553
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 224
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.35
    Marker Score: 842
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 230.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.35
    Marker Score: 120
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.34
    Marker Score: 178
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.31
    Marker Score: 196
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3
    Marker Score: 320
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 139
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.29
    Marker Score: 220
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.26
    Marker Score: 177
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.25
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.25
    Marker Score: 67
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.23
    Marker Score: 193
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.22
    Marker Score: 155
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.22
    Marker Score: 68
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.21
    Marker Score: 54
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2
    Marker Score: 47
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.2
    Marker Score: 76
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.2
    Marker Score: 1055
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.2
    Marker Score: 954
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.2
    Marker Score: 284
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.19
    Marker Score: 99
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.19
    Marker Score: 46
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.17
    Marker Score: 174
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.17
    Marker Score: 62
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.17
    Marker Score: 279
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.16
    Marker Score: 50

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Other Information

**Key characteristics:** - The ALDH3A1 gene is located on chromosome 15q21.1. - It is a large gene with a length of approximately 12.5 kb. - The protein is composed of 131 amino acids. **Pathways and functions:** - The ALDH3A1 protein is involved in a variety of pathways, including the detoxification of aldehydes, the metabolism of alcohol, and the synthesis of lipids. - It is involved in the maintenance of cellular homeostasis by detoxifying aldehydes produced by various metabolic processes. - It is also involved in the regulation of inflammation. **Clinical significance:** - Mutations in the ALDH3A1 gene have been linked to a number of human diseases, including liver disease, cancer, and eye diseases. - These mutations can lead to the accumulation of aldehydes in the body, which can damage cells and tissues. - Targeting ALDH3A1 has been explored as a therapeutic strategy for these diseases. **Additional notes:** - The ALDH3A1 protein is a dimer, meaning that it consists of two identical subunits that are held together by a disulfide bond. - The protein is expressed in high levels in the liver and other tissues that are involved in detoxification. - The protein is also expressed in the eyes, where it is involved in the metabolism of aldehydes produced by the retina.

Genular Protein ID: 4033907070

Symbol: AL3A1_HUMAN

Name: Aldehyde dehydrogenase, dimeric NADP-preferring

UniProtKB Accession Codes:

P30838 A8K828 Q9BT37

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 11 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1737758

Title: Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli.

PubMed ID: 1737758

DOI: 10.1016/s0021-9258(19)50690-1

PubMed ID: 8493892

Title: Human stomach aldehyde dehydrogenase, ALDH3.

PubMed ID: 8493892

DOI: 10.1007/978-1-4615-2904-0_16

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2037078

Title: Structural features of stomach aldehyde dehydrogenase distinguish dimeric aldehyde dehydrogenase as a 'variable' enzyme. 'Variable' and 'constant' enzymes within the alcohol and aldehyde dehydrogenase families.

PubMed ID: 2037078

DOI: 10.1016/0014-5793(91)80559-l

PubMed ID: 1905102

Title: Biochemical, immunological, and molecular characterization of a 'high Km' aldehyde dehydrogenase.

PubMed ID: 1905102

DOI: 10.1007/978-1-4684-5901-2_6

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22021038

Title: Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.

PubMed ID: 22021038

DOI: 10.1074/jbc.m111.293597

PubMed ID: 9250352

Title: Mutations associated with Sjogren-Larsson syndrome.

PubMed ID: 9250352

DOI: 10.1046/j.1469-1809.1997.6130235.x

Sequence Information:

  • Length: 453
  • Mass: 50395
  • Checksum: D35C488A022FAACA
  • Sequence:
    • MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY 
YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGVVLV IGTWNYPFNL 
TIQPMVGAIA AGNSVVLKPS ELSENMASLL ATIIPQYLDK DLYPVINGGV PETTELLKER 
FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS 
GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG 
QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE AIQFINQREK 
PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE 
TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH

Genular Protein ID: 3135564349

Symbol: I3L3I9_HUMAN

Name: N/A

UniProtKB Accession Codes:

I3L3I9

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 EC 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 2 Rhea 2 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 380
  • Mass: 41857
  • Checksum: CA6C7A516403836A
  • Sequence:
    • MIQKLPEWAA DEPVEKTPQT QQDELYIHSE PLGVVLVIGT WNYPFNLTIQ PMVGAIAAGN 
SVVLKPSELS ENMASLLATI IPQYLDKDLY PVINGGVPET TELLKERFDH ILYTGSTGVG 
KIIMTAAAKH LTPVTLELGG KSPCYVDKNC DLDVACRRIA WGKFMNSGQT CVAPDYILCD 
PSIQNQIVEK LKKSLKEFYG EDAKKSRDYG RIISARHFQR VMGLIEGQKV AYGGTGDAAT 
RYIAPTILTD VDPQSPVMQE EIFGPVLPIV CVRSLEEAIQ FINQREKPLA LYMFSSNDKV 
IKKMIAETSS GGVAANDVIV HITLHSLPFG GVGNSGMGSY HGKKSFETFS HRRSCLVRPL 
MNDEGLKVRY PPSPAKMTQH

Genular Protein ID: 3117574655

Symbol: Q6PKA6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PKA6

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 2 Genevisible 1 GenomeRNAi 1 InterPro 7 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 Rhea 2 RuleBase 1 SAM 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 512
  • Mass: 57510
  • Checksum: 9316E56FCC008829
  • Sequence:
    • EVQRTPHPTF EYFFFLSRKL PGQELQGLNG REAGSLNTSP LGSCRSRSPS YRERLCQRRH 
EQDQRGREAR PRRLQLGRTR PLQFRIQQLE ALQRLIQEQE QELVGALAAD LHKNEWNAYY 
EEVVYVLEEI EYMIQKLPEW AADEPVEKTP QTQQDELYIH SEPLGVVLVI GTWNYPFNLT 
IQPMVGAIAA GNAVVLKPSE LSENMASLLA TIIPQYLDKD LYPVINGGVP ETTELLKERF 
DHILYTGSTG VGKIIMTAAA KHLTPVTLEL GGKSPCYVDK NCDLDVACRR IAWGKFMNSG 
QTCVAPDYIL CDPSIQNQIV EKLKKSLKEF YGEDAKKSRD YGRIISARHF QRVMGLIEGQ 
KVAYGGTGDA ATRYIAPTIL TDVDPQSPVM QEEIFGPVLP IVCVRSLEEA IQFINQREKP 
LALYMFSSND KVIKKMIAET SSGGVAANDV IVHITLHSLP FGGVGNSGMG SYHGKKSFET 
FSHRRSCLVR PLMNDEGLKV RYPPSPAKMT QH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.