Genular: Defining Cellular Identity and Function

Details for: Tgfb1

Gene ID: 21803

Symbol: Tgfb1

Ensembl ID: ENSMUSG00000002603

Description: transforming growth factor, beta 1

Associated with

Cell surface interactions at the vascular wall
(R-MMU-202733)
Downregulation of tgf-beta receptor signaling
(R-MMU-2173788)
Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hemostasis
(R-MMU-109582)
Molecules associated with elastic fibres
(R-MMU-2129379)
Non-integrin membrane-ecm interactions
(R-MMU-3000171)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Regulation of runx3 expression and activity
(R-MMU-8941858)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Rna polymerase ii transcription
(R-MMU-73857)
Runx3 regulates cdkn1a transcription
(R-MMU-8941855)
Runx3 regulates p14-arf
(R-MMU-8951936)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Syndecan interactions
(R-MMU-3000170)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Tgf-beta receptor signaling in emt (epithelial to mesenchymal transition)
(R-MMU-2173791)
Transcriptional regulation by runx3
(R-MMU-8878159)
Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
(GO:0002460)
Animal organ morphogenesis
(GO:0009887)
Antigen binding
(GO:0003823)
Aortic valve morphogenesis
(GO:0003180)
Atp biosynthetic process
(GO:0006754)
Cd4-positive, cd25-positive, alpha-beta regulatory t cell lineage commitment
(GO:0002362)
Cell activation
(GO:0001775)
Cell morphogenesis
(GO:0000902)
Cell population proliferation
(GO:0008283)
Chondrocyte differentiation
(GO:0002062)
Columnar/cuboidal epithelial cell maturation
(GO:0002069)
Cytokine activity
(GO:0005125)
Defense response
(GO:0006952)
Deubiquitinase activator activity
(GO:0035800)
Endoderm development
(GO:0007492)
Enzyme binding
(GO:0019899)
Epithelial to mesenchymal transition
(GO:0001837)
Gene expression
(GO:0010467)
Germ cell migration
(GO:0008354)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Heart valve morphogenesis
(GO:0003179)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Intracellular calcium ion homeostasis
(GO:0006874)
Morphogenesis of a branching structure
(GO:0001763)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of macrophage cytokine production
(GO:0010936)
Negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
(GO:0002859)
Negative regulation of neuroblast proliferation
(GO:0007406)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube closure
(GO:0001843)
Notch signaling pathway
(GO:0007219)
Phosphate-containing compound metabolic process
(GO:0006796)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of gene expression
(GO:0010628)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein export from nucleus
(GO:0006611)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of gene expression
(GO:0010468)
Regulation of sodium ion transport
(GO:0002028)
Response to organic substance
(GO:0010033)
Skeletal muscle tissue development
(GO:0007519)
Skeletal system development
(GO:0001501)
Sprouting angiogenesis
(GO:0002040)
Tolerance induction to self antigen
(GO:0002513)
Transforming growth factor beta receptor binding
(GO:0005160)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Type iii transforming growth factor beta receptor binding
(GO:0034714)
Type ii transforming growth factor beta receptor binding
(GO:0005114)
Type i transforming growth factor beta receptor binding
(GO:0034713)
Ureteric bud development
(GO:0001657)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

Transforming growth factor beta-1 proprotein

Genular Protein ID: 4192035524

Symbol: TGFB1_MOUSE

Name: Transforming growth factor beta-1 proprotein

UniProtKB Accession Codes:

P04202

Database IDs:

Citations:

PubMed ID: 3007454

Title: The murine transforming growth factor-beta precursor.

PubMed ID: 3007454

DOI: 10.1016/s0021-9258(17)38511-3

PubMed ID: 8522200

Title: Molecular organization of the gene encoding murine transforming growth factor beta 1.

PubMed ID: 8522200

DOI: 10.1016/0378-1119(95)00460-n

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10025398

Title: The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

PubMed ID: 10025398

DOI: 10.1016/s0092-8674(00)80545-0

PubMed ID: 14985127

Title: P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2.

PubMed ID: 14985127

DOI: 10.1016/j.bbrc.2004.01.171

PubMed ID: 15206957

Title: Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling.

PubMed ID: 15206957

DOI: 10.1111/j.1440-169x.2004.00743.x

PubMed ID: 14973287

Title: HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins.

PubMed ID: 14973287

DOI: 10.1242/dev.00999

PubMed ID: 18368049

Title: TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.

PubMed ID: 18368049

DOI: 10.1038/nature06878

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19745830

Title: TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival.

PubMed ID: 19745830

DOI: 10.1038/cdd.2009.126

PubMed ID: 21880733

Title: ADAMTSL6beta protein rescues fibrillin-1 microfibril disorder in a Marfan syndrome mouse model through the promotion of fibrillin-1 assembly.

PubMed ID: 21880733

DOI: 10.1074/jbc.m111.243451

PubMed ID: 22781750

Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.

PubMed ID: 22781750

DOI: 10.1016/j.cellsig.2012.07.003

PubMed ID: 22995554

Title: Tsukushi controls the hair cycle by regulating TGF-beta1 signaling.

PubMed ID: 22995554

DOI: 10.1016/j.ydbio.2012.08.030

PubMed ID: 26858265

Title: Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.

PubMed ID: 26858265

DOI: 10.1083/jcb.201507018

PubMed ID: 29909984

Title: A milieu molecule for TGF-beta required for microglia function in the nervous system.

PubMed ID: 29909984

DOI: 10.1016/j.cell.2018.05.027

PubMed ID: 33548622

Title: Effects of transforming growth factor-beta1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level.

PubMed ID: 33548622

DOI: 10.1016/j.bbrc.2021.01.076

Sequence Information:

Length: 390
Mass: 44310
Checksum: 4381A51B711D689E
Sequence:

MPPSGLRLLP LLLPLPWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR GQILSKLRLA 
SPPSQGEVPP GPLPEAVLAL YNSTRDRVAG ESADPEPEPE ADYYAKEVTR VLMVDRNNAI 
YEKTKDISHS IYMFFNTSDI REAVPEPPLL SRAELRLQRL KSSVEQHVEL YQKYSNNSWR 
YLGNRLLTPT DTPEWLSFDV TGVVRQWLNQ GDGIQGFRFS AHCSCDSKDN KLHVEINGIS 
PKRRGDLGTI HDMNRPFLLL MATPLERAQH LHSSRHRRAL DTNYCFSSTE KNCCVRQLYI 
DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA SASPCCVPQA 
LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tgfb1

Associated with

Other Information

The murine transforming growth factor-beta precursor. PubMed ID: 3007454

Molecular organization of the gene encoding murine transforming growth factor beta 1. PubMed ID: 8522200

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. PubMed ID: 10025398

P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2. PubMed ID: 14985127

Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. PubMed ID: 15206957

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. PubMed ID: 14973287

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. PubMed ID: 18368049

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival. PubMed ID: 19745830

ADAMTSL6beta protein rescues fibrillin-1 microfibril disorder in a Marfan syndrome mouse model through the promotion of fibrillin-1 assembly. PubMed ID: 21880733

Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway. PubMed ID: 22781750

Tsukushi controls the hair cycle by regulating TGF-beta1 signaling. PubMed ID: 22995554

Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. PubMed ID: 26858265

A milieu molecule for TGF-beta required for microglia function in the nervous system. PubMed ID: 29909984

Effects of transforming growth factor-beta1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level. PubMed ID: 33548622