Genular: Defining Cellular Identity and Function

Details for: Tgfbr3

Gene ID: 21814

Symbol: Tgfbr3

Ensembl ID: ENSMUSG00000029287

Description: transforming growth factor, beta receptor III

Associated with

Fgfr1 ligand binding and activation
(R-MMU-190242)
Fgfr1b ligand binding and activation
(R-MMU-190370)
Fgfr1c ligand binding and activation
(R-MMU-190373)
Signaling by activin
(R-MMU-1502540)
Signaling by bmp
(R-MMU-201451)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Activin binding
(GO:0048185)
Apoptotic process involved in morphogenesis
(GO:0060561)
Blastocyst development
(GO:0001824)
Blood vessel development
(GO:0001568)
Blood vessel diameter maintenance
(GO:0097746)
Blood vessel remodeling
(GO:0001974)
Bmp binding
(GO:0036122)
Bmp signaling pathway
(GO:0030509)
Cardiac epithelial to mesenchymal transition
(GO:0060317)
Cardiac muscle cell proliferation
(GO:0060038)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Collagen metabolic process
(GO:0032963)
Coreceptor activity
(GO:0015026)
Coronary vasculature development
(GO:0060976)
Coronary vasculature morphogenesis
(GO:0060977)
Definitive erythrocyte differentiation
(GO:0060318)
Definitive hemopoiesis
(GO:0060216)
Epicardial cell to mesenchymal cell transition
(GO:0003347)
Epicardium-derived cardiac fibroblast cell development
(GO:0060939)
Epithelial to mesenchymal transition
(GO:0001837)
Fibroblast growth factor binding
(GO:0017134)
Glycosaminoglycan binding
(GO:0005539)
Heart trabecula formation
(GO:0060347)
Heart trabecula morphogenesis
(GO:0061384)
Heparin binding
(GO:0008201)
Immune response
(GO:0006955)
Intracellular signal transduction
(GO:0035556)
In utero embryonic development
(GO:0001701)
Liver development
(GO:0001889)
Muscular septum morphogenesis
(GO:0003150)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of epithelial cell migration
(GO:0010633)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of extracellular matrix assembly
(GO:1901202)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of smad protein signal transduction
(GO:0060392)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Osteoblast differentiation
(GO:0001649)
Outflow tract morphogenesis
(GO:0003151)
Pdz domain binding
(GO:0030165)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of smad protein signal transduction
(GO:0060391)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of jnk cascade
(GO:0046328)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Response to follicle-stimulating hormone
(GO:0032354)
Response to luteinizing hormone
(GO:0034699)
Response to prostaglandin e
(GO:0034695)
Roof of mouth development
(GO:0060021)
Secondary palate development
(GO:0062009)
Smad binding
(GO:0046332)
Transforming growth factor beta binding
(GO:0050431)
Transforming growth factor beta receptor activity
(GO:0005024)
Transforming growth factor beta receptor activity, type iii
(GO:0070123)
Transforming growth factor beta receptor binding
(GO:0005160)
Transforming growth factor beta receptor complex assembly
(GO:0007181)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Transmembrane signaling receptor activity
(GO:0004888)
Type ii transforming growth factor beta receptor binding
(GO:0005114)
Vasculogenesis
(GO:0001570)
Vasculogenesis involved in coronary vascular morphogenesis
(GO:0060979)
Ventricular cardiac muscle tissue morphogenesis
(GO:0055010)
Ventricular compact myocardium morphogenesis
(GO:0003223)
Ventricular septum morphogenesis
(GO:0060412)
Visceral serous pericardium development
(GO:0061032)

Other Information

Proteins

Transforming growth factor beta receptor type 3
A0A0R4J097_MOUSE

Genular Protein ID: 3173698870

Symbol: TGBR3_MOUSE

Name: Transforming growth factor beta receptor type 3

UniProtKB Accession Codes:

O88393 Q6NS72

Database IDs:

Citations:

PubMed ID: 9659379

Title: Murine betaglycan primary structure, expression and glycosaminoglycan attachment sites.

PubMed ID: 9659379

DOI: 10.1016/s0167-4838(98)00033-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 30364975

Title: Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in Mice.

PubMed ID: 30364975

DOI: 10.1210/en.2018-00770

PubMed ID: 34910520

Title: TGFBR3L is an inhibin B co-receptor that regulates female fertility.

PubMed ID: 34910520

DOI: 10.1126/sciadv.abl4391

PubMed ID: 23826237

Title: Identification of a novel TGF-beta-binding site in the zona pellucida C-terminal (ZP-C) domain of TGF-beta-receptor-3 (TGFR-3).

PubMed ID: 23826237

DOI: 10.1371/journal.pone.0067214

Sequence Information:

Length: 850
Mass: 93829
Checksum: 4154D034C7307C86
Sequence:

MAVTSHHMVP VFVLMSACLA TAGPEPSTRC ELSPISASHP VQALMESFTV LSGCASRGTT 
GLPREVHILN LRSTDQGLGQ PQREVTLHLN PIASVHTHHK PVVFLLNSPQ PLVWHVKTER 
LAAGVPRLFL VSEGSVVQFS SGNFSLTAET EERSFPQENE HLLHWAQKEY GAVTSFTELK 
IARNIYIKVG EDQVFPPTCN IGKNFLSLNY LAEYLQPKAA EGCVLASQPH EKEVHIIELI 
SPNSNPYSTF QVDIIIDIRP AREDPEVVKN LVLILKCKKS VNWVIKSFDV KGNLKVIAPD 
SIGFGKESER SMTVTKLVRN DYPSTQENLM KWALDNGYSP VTSYTIAPVA NRFHLRLENN 
EEMRDEEVHT IPPELRILLG PDHLPALDSP PFQGEIPNGG FPFPFPDIPR RGWKEGEDRI 
PRPKEPIIPR VQLLPDHREP EEVQGGVNIA LSVKCDNEKM VVAVDKDSFQ TNGYSGMELT 
LLDPSCKAKM NGTHFVLESP LNGCGTRHRR SAPDGVVYYN SIVVQAPSPG DSSGWPDGYE 
DLESGDNGFP GDTDEGETAP LSRAGVVVFN CSLRQLRSPS GFQDQLDGNA TFNMELYNTD 
LFLVPSPGVF SVAENEHVYV EVSVTKADQD LGFAIQTCFI SPYSNPDRMS DYTIIENICP 
KDDSVKFYSS KRVHFPIPHA EVDKKRFSFV FKSVFNTSLL FLHCELTLCS RNKGSQKLPK 
CVTPDDACTS LDATMIWTMM QNKKTFTKPL AVVLQVDYKE NVPNMKESSP VPPPPQIFHG 
LDTLTVMGIA FAAFVIGALL TGALWYIYSH TGETARRQQV PTSPPASENS SAAHSIGSTQ 
STPCSSSSTA

Genular Protein ID: 1340647462

Symbol: A0A0R4J097_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J097

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 850
Mass: 93783
Checksum: 3FF32776FEF082C7
Sequence:

MAVTSHHMVP VFVLMSACLA TAGPEPSTRC ELSPISASHP VQALMESFTV LSGCASRGTT 
GLPREVHILN LRSTDQGLGQ PQREVTLHLN PIASVHTHHK PVVFLLNSPQ PLVWHVKTER 
LAAGVPRLFL VSEGSVVQFS SGNFSLTAET EERSFPQENE HLLHWAQKEY GAVTSFTELK 
IARNIYIKVG EDQVFPPTCN IGKNFLSLNY LAEYLQPKAA EGCVLASQPH EKEVHIIELI 
SPNSNPYSTF QVDIIIDIRP AREDPEVVKN LVLILKCKKS VNWVIKSFDV KGNLKVIAPD 
SIGFGKESER SMTVTKLVRN DIPSTQENLM KWALDNGYSP VTSYTIAPVA NRFHLRLENN 
EEMRDEEVHT IPPELRILLG PDHLPALDSP SFQGEIPNGG FPFPFPDIPR RGWKEGEDRI 
PRPKEPIIPR VQLLPDHREP EEVQGGVNIA LSVKCDNEKM VVAVDKDSFQ TNGYSGMELT 
LLDPSCKAKM NGTHFVLESP LNGCGTRHRR SAPDGVVYYN SIVVQAPSPG DSSGWPDGYE 
DLESGDNGFP GDTDEGETAP LSRAGVVVFN CSLRQLRSPS GFQDQLDGNA TFNMELYNTD 
LFLVPSPGVF SVAENEHVYV EVSVTKADQD LGFAIQTCFI SPYSNPDRMS DYTIIENICP 
KDDSVKFYSS KRVHFPIPHA EVDKKRFSFV FKSVFNTSLL FLHCELTLCS RKKGSQKLPK 
CVTPDDACTS LDATMIWTMM QNKKTFTKPL AVVLQVDYKE NVPNMKESSP VPPPPQIFHG 
LDTLTVMGIA FAAFVIGALL TGALWYIYSH TGETARRQQV PTSPPASENS SAAHSIGSTQ 
STPCSSSSTA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tgfbr3

Associated with

Other Information

Murine betaglycan primary structure, expression and glycosaminoglycan attachment sites. PubMed ID: 9659379

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in Mice. PubMed ID: 30364975

TGFBR3L is an inhibin B co-receptor that regulates female fertility. PubMed ID: 34910520

Identification of a novel TGF-beta-binding site in the zona pellucida C-terminal (ZP-C) domain of TGF-beta-receptor-3 (TGFR-3). PubMed ID: 23826237