Genular: Defining Cellular Identity and Function

Details for: Th

Gene ID: 21823

Symbol: Th

Ensembl ID: ENSMUSG00000000214

Description: tyrosine hydroxylase

Associated with

Catecholamine biosynthesis
(R-MMU-209905)
Metabolism
(R-MMU-1430728)
Metabolism of amine-derived hormones
(R-MMU-209776)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Aminergic neurotransmitter loading into synaptic vesicle
(GO:0015842)
Amino acid binding
(GO:0016597)
Animal organ morphogenesis
(GO:0009887)
Aromatic amino acid metabolic process
(GO:0009072)
Axon
(GO:0030424)
Catecholamine biosynthetic process
(GO:0042423)
Cell projection
(GO:0042995)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytoplasmic vesicle
(GO:0031410)
Cytoplasmic vesicle membrane
(GO:0030659)
Dendrite
(GO:0030425)
Dopamine binding
(GO:0035240)
Dopamine biosynthetic process
(GO:0042416)
Dopamine biosynthetic process from tyrosine
(GO:0006585)
Eating behavior
(GO:0042755)
Embryonic camera-type eye morphogenesis
(GO:0048596)
Enzyme binding
(GO:0019899)
Epinephrine biosynthetic process
(GO:0042418)
Eye photoreceptor cell development
(GO:0042462)
Ferric iron binding
(GO:0008199)
Ferrous iron binding
(GO:0008198)
Heart development
(GO:0007507)
Hyaloid vascular plexus regression
(GO:1990384)
Identical protein binding
(GO:0042802)
Iron ion binding
(GO:0005506)
Learning
(GO:0007612)
Locomotory behavior
(GO:0007626)
Mating behavior
(GO:0007617)
Melanosome membrane
(GO:0033162)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Monooxygenase activity
(GO:0004497)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Norepinephrine biosynthetic process
(GO:0042421)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
(GO:0016714)
Oxygen binding
(GO:0019825)
Perikaryon
(GO:0043204)
Perinuclear region of cytoplasm
(GO:0048471)
Protein domain specific binding
(GO:0019904)
Regulation of heart contraction
(GO:0008016)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Small molecule binding
(GO:0036094)
Smooth endoplasmic reticulum
(GO:0005790)
Synapse
(GO:0045202)
Synaptic transmission, dopaminergic
(GO:0001963)
Synaptic vesicle
(GO:0008021)
Terminal bouton
(GO:0043195)
Tetrahydrobiopterin binding
(GO:0034617)
Tyrosine 3-monooxygenase activity
(GO:0004511)
Visual perception
(GO:0007601)

Other Information

Proteins

Tyrosine 3-monooxygenase

Genular Protein ID: 2390816861

Symbol: TY3H_MOUSE

Name: Tyrosine 3-monooxygenase

UniProtKB Accession Codes:

P24529

Database IDs:

Citations:

PubMed ID: 1674869

Title: Primary structure of mouse tyrosine hydroxylase deduced from its cDNA.

PubMed ID: 1674869

DOI: 10.1016/0006-291x(91)90472-j

PubMed ID: 7715703

Title: Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development.

PubMed ID: 7715703

DOI: 10.1038/374640a0

PubMed ID: 17296554

Title: Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.

PubMed ID: 17296554

DOI: 10.1016/j.neuron.2007.01.019

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 30936473

Title: An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye.

PubMed ID: 30936473

DOI: 10.1038/s41556-019-0301-x

Sequence Information:

Length: 498
Mass: 55993
Checksum: 62790179664F6DC6
Sequence:

MPTPSASSPQ PKGFRRAVSE QDTKQAEAVT SPRFIGRRQS LIEDARKERE AAAAAAAAAV 
ASAEPGNPLE AVVFEERDGN AVLNLLFSLR GTKPSSLSRA LKVFETFEAK IHHLETRPAQ 
RPLAGSPHLE YFVRFEVPSG DLAALLSSVR RVSDDVRSAR EDKVPWFPRK VSELDKCHHL 
VTKFDPDLDL DHPGFSDQAY RQRRKLIAEI AFQYKQGEPI PHVEYTKEEI ATWKEVYATL 
KGLYATHACR EHLEAFQLLE RYCGYREDSI PQLEDVSHFL KERTGFQLRP VAGLLSARDF 
LASLAFRVFQ CTQYIRHASS PMHSPEPDCC HELLGHVPML ADRTFAQFSQ DIGLASLGAS 
DEEIEKLSTV YWFTVEFGLC KQNGELKAYG AGLLSSYGEL LHSLSEEPEV RAFDPDTAAV 
QPYQDQTYQP VYFVSESFSD AKDKLRNYAS RIQRPFSVKF DPYTLAIDVL DSPHTIRRSL 
EGVQDELHTL TQALSAIS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Th

Associated with

Other Information

Primary structure of mouse tyrosine hydroxylase deduced from its cDNA. PubMed ID: 1674869

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. PubMed ID: 7715703

Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. PubMed ID: 17296554