Details for: Thbs1

Gene ID: 21825

Symbol: Thbs1

Ensembl ID: ENSMUSG00000040152

Description: thrombospondin 1

Associated with

  • Extracellular matrix organization
    (R-MMU-1474244)
  • Hemostasis
    (R-MMU-109582)
  • Integrin cell surface interactions
    (R-MMU-216083)
  • Metabolism of proteins
    (R-MMU-392499)
  • O-glycosylation of tsr domain-containing proteins
    (R-MMU-5173214)
  • O-linked glycosylation
    (R-MMU-5173105)
  • Platelet activation, signaling and aggregation
    (R-MMU-76002)
  • Platelet degranulation
    (R-MMU-114608)
  • Post-translational protein modification
    (R-MMU-597592)
  • Response to elevated platelet cytosolic ca2+
    (R-MMU-76005)
  • Signaling by pdgf
    (R-MMU-186797)
  • Signaling by receptor tyrosine kinases
    (R-MMU-9006934)
  • Signal transduction
    (R-MMU-162582)
  • Angiogenesis
    (GO:0001525)
  • Apoptotic process
    (GO:0006915)
  • Behavioral response to pain
    (GO:0048266)
  • Blood vessel morphogenesis
    (GO:0048514)
  • Calcium ion binding
    (GO:0005509)
  • Cell adhesion
    (GO:0007155)
  • Cell migration
    (GO:0016477)
  • Cellular response to nitric oxide
    (GO:0071732)
  • Collagen v binding
    (GO:0070052)
  • Endocardial cushion development
    (GO:0003197)
  • Endopeptidase inhibitor activity
    (GO:0004866)
  • Engulfment of apoptotic cell
    (GO:0043652)
  • Extracellular matrix binding
    (GO:0050840)
  • Extracellular matrix structural constituent
    (GO:0005201)
  • Fibrinogen binding
    (GO:0070051)
  • Fibroblast growth factor binding
    (GO:0017134)
  • Fibronectin binding
    (GO:0001968)
  • Growth plate cartilage development
    (GO:0003417)
  • Heparin binding
    (GO:0008201)
  • Inflammatory response
    (GO:0006954)
  • Integrin binding
    (GO:0005178)
  • Laminin binding
    (GO:0043236)
  • Low-density lipoprotein particle binding
    (GO:0030169)
  • Monocyte aggregation
    (GO:0070487)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii
    (GO:0002581)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of blood vessel endothelial cell migration
    (GO:0043537)
  • Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    (GO:1903588)
  • Negative regulation of cell-matrix adhesion
    (GO:0001953)
  • Negative regulation of cell migration involved in sprouting angiogenesis
    (GO:0090051)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cgmp-mediated signaling
    (GO:0010754)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of dendritic cell antigen processing and presentation
    (GO:0002605)
  • Negative regulation of endothelial cell migration
    (GO:0010596)
  • Negative regulation of endothelial cell proliferation
    (GO:0001937)
  • Negative regulation of fibrinolysis
    (GO:0051918)
  • Negative regulation of fibroblast growth factor receptor signaling pathway
    (GO:0040037)
  • Negative regulation of interleukin-12 production
    (GO:0032695)
  • Negative regulation of long-chain fatty acid import across plasma membrane
    (GO:0010748)
  • Negative regulation of nitric oxide mediated signal transduction
    (GO:0010751)
  • Negative regulation of plasminogen activation
    (GO:0010757)
  • Negative regulation of sprouting angiogenesis
    (GO:1903671)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Peptide cross-linking
    (GO:0018149)
  • Phosphatidylserine binding
    (GO:0001786)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood coagulation
    (GO:0030194)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of cell-substrate adhesion
    (GO:0010811)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemotaxis
    (GO:0050921)
  • Positive regulation of endothelial cell apoptotic process
    (GO:2000353)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
    (GO:1902043)
  • Positive regulation of fibroblast migration
    (GO:0010763)
  • Positive regulation of macrophage activation
    (GO:0043032)
  • Positive regulation of macrophage chemotaxis
    (GO:0010759)
  • Positive regulation of map kinase activity
    (GO:0043406)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of phosphorylation
    (GO:0042327)
  • Positive regulation of reactive oxygen species metabolic process
    (GO:2000379)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of transforming growth factor beta production
    (GO:0071636)
  • Positive regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030511)
  • Positive regulation of translation
    (GO:0045727)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protease binding
    (GO:0002020)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Response to calcium ion
    (GO:0051592)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to glucose
    (GO:0009749)
  • Response to magnesium ion
    (GO:0032026)
  • Response to mechanical stimulus
    (GO:0009612)
  • Response to unfolded protein
    (GO:0006986)
  • Sprouting angiogenesis
    (GO:0002040)
  • Transforming growth factor beta binding
    (GO:0050431)

Other Information

Genular Protein ID: 2544039115

Symbol: Q3TR40_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TR40

Database IDs:

AGR 1 ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 5 Google 1 InterPro 13 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 10 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 6 RefSeq 2 SAM 2 SMART 5 SUPFAM 5 UCSC 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 1170
  • Mass: 129619
  • Checksum: 55BF04A20D91B194
  • Sequence:
    • MELLRGLGVL FLLHMCGSNR IPESGGDNGV FDIFELIGGA RRGPGRRLVK GQDLSSPAFR 
IENANLIPAV PDDKFQDLLD AVWADKGFIF LASLRQMKKT RGTLLAVERK DNTGQIFSVV 
SNGKAGTLDL SLSLPGKQQV VSVEEALLAT GQWKSITLFV QEDRAQLYID CDKMESAELD 
VPIQSIFTRD LASVARLRVA KGDVNDNFQG VLQNVRFVFG TTPEDILRNK GCSSSTNVLL 
TLDNNVVNGS SPAIRTNYIG HKTKDLQAIC GLSCDELSSM VLELKGLRTI VTTLQDSIRK 
VTEENRELVS ELKRPPLCFH NGVQYKNNEE WTVDSCTECH CQNSVTICKK VSCPIMPCSN 
ATVPDGECCP RCWPSDSADD GWSPWSEWTS CSATCGNGIQ QRGRSCDSLN NRCEGSSVQT 
RTCHIQECDK RFKQDGGWSH WSPWSSCSVT CGDGVITRIR LCNSPSPQMN GKPCEGEARE 
TKACKKDACP INGGWGPWSP WDICSVTCGG GVQRRSRLCN NPTPQFGGKD CVGDVTENQV 
CNKQDCPIDG CLSNPCFAGA KCTSYPDGSW KCGACPPGYS GNGIQCKDVD ECKEVPDACF 
NHNGEHRCKN TDPGYNCLPC PPRFTGSQPF GRGVEHAMAN KQVCKPRNPC TDGTHDCNKN 
AKCNYLGHYS DPMYRCECKP GYAGNGIICG EDTDLDGWPN ENLVCVANAT YHCKKDNCPN 
LPNSGQEDYD KDGIGDACDD DDDNDKIPDD RDNCPFHYNP AQYDYDRDDV GDRCDNCPYN 
HNPDQADTDK NGEGDACAVD IDGDGILNER DNCQYVYNVD QRDTDMDGVG DQCDNCPLEH 
NPDQLDSDSD LIGDTCDNNQ DIDEDGHQNN LDNCPYVPNA NQADHDKDGK GDACDHDDDN 
DGIPDDRDNC RLVPNPDQKD SDGDGRGDAC KDDFDHDNVP DIDDICPENF DISETDFRQF 
QMIPLDPKGT SQNDPNWVVR HQGKELVQTV NCDPGLAVGY DEFNAVDFSG TFFINTERDD 
DYAGFVFGYQ SSSRFYVVMW KQVTQSYWDT NPTRAQGYSG LSVKVVNSTT GPGEHLRNAL 
WHTGNTPGQV RTLWHDPRHI GWKDFTAYRW RLSHRPKTGY IRVVMYEGKK IMADSGPIYD 
KTYAGGRLGL FVFSQEMVFF SDMKYECRDS

Genular Protein ID: 701800188

Symbol: Q80YQ1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q80YQ1

Database IDs:

AGR 1 ARBA 9 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 GO 62 Gene3D 5 GeneTree 1 HOGENOM 1 InterPro 13 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 10 PROSITE-ProRule 2 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 2 SMART 5 SMR 1 SUPFAM 5 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 1171
  • Mass: 129690
  • Checksum: 12E077B50C64E2D3
  • Sequence:
    • MELLRGLGVL FLLHMCGSNR IPESGGDNGV FDIFELIGGA RRGPGRRLVK GQDLSSPAFR 
IENANLIPAV PDDKFQDLLD AVWADKGFIF LASLRQMKKT RGTLLAVERK DNTGQIFSVV 
SNGKAGTLDL SLSLPGKQQV VSVEEALLAT GQWKSITLFV QEDRAQLYID CDKMESAELD 
VPIQSIFTRD LASVARLRVA KGDVNDNFQG VLQNVRFVFG TTPEDILRNK GCSSSATNVL 
LTLDNNVVNG SSPAIRTNYI GHKTKDLQAI CGLSCDELSS MVLELKGLRT IVTTLQDSIR 
KVTEENRELV SELKRPPLCF HNGVQYKNNE EWTVDSCTEC HCQNSVTICK KVSCPIMPCS 
NATVPDGECC PRCWPSDSAD DGWSPWSEWT SCSATCGNGI QQRGRSCDSL NNRCEGSSVQ 
TRTCHIQECD KRFKQDGGWS HWSPWSSCSV TCGDGVITRI RLCNSPSPQM NGKPCEGEAR 
ETKACKKDAC PINGGWGPWS PWDICSVTCG GGVQRRSRLC NNPTPQFGGK DCVGDVTENQ 
VCNKQDCPID GCLSNPCFAG AKCTSYPDGS WKCGACPPGY SGNGIQCKDV DECKEVPDAC 
FNHNGEHRCK NTDPGYNCLP CPPRFTGSQP FGRGVEHAMA NKQVCKPRNP CTDGTHDCNK 
NAKCNYLGHY SDPMYRCECK PGYAGNGIIC GEDTDLDGWP NENLVCVANA TYHCKKDNCP 
NLPNSGQEDY DKDGIGDACD DDDDNDKIPD DRDNCPFHYN PAQYDYDRDD VGDRCDNCPY 
NHNPDQADTD KNGEGDACAV DIDGDGILNE RDNCQYVYNV DQRDTDMDGV GDQCDNCPLE 
HNPDQLDSDS DLIGDTCDNN QDIDEDGHQN NLDNCPYVPN ANQADHDKDG KGDACDHDDD 
NDGIPDDRDN CRLVPNPDQK DSDGDGRGDA CKDDFDHDNV PDIDDICPEN FDISETDFRQ 
FQMIPLDPKG TSQNDPNWVV RHQGKELVQT VNCDPGLAVG YDEFNAVDFS GTFFINTERD 
DDYAGFVFGY QSSSRFYVVM WKQVTQSYWD TNPTRAQGYS GLSVKVVNST TGPGEHLRNA 
LWHTGNTPGQ VRTLWHDPRH IGWKDFTAYR WRLSHRPKTG YIRVVMYEGK KIMADSGPIY 
DKTYAGGRLG LFVFSQEMVF FSDMKYECRD S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.