Details for: Thpo

Gene ID: 21832

Symbol: Thpo

Ensembl ID: ENSMUSG00000022847

Description: thrombopoietin

Associated with

  • Cell population proliferation
    (GO:0008283)
  • Cytokine activity
    (GO:0005125)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Hormone activity
    (GO:0005179)
  • Megakaryocyte development
    (GO:0035855)
  • Megakaryocyte differentiation
    (GO:0030219)
  • Myeloid cell differentiation
    (GO:0030099)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of hematopoietic stem cell proliferation
    (GO:1902035)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of megakaryocyte differentiation
    (GO:0045654)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Receptor signaling pathway via stat
    (GO:0097696)
  • Signaling receptor binding
    (GO:0005102)
  • Thrombopoietin-mediated signaling pathway
    (GO:0038163)

Other Information

Genular Protein ID: 558703516

Symbol: TPO_MOUSE

Name: Thrombopoietin

UniProtKB Accession Codes:

P40226

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 3 SAM 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 8202158

Title: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo.

PubMed ID: 8202158

DOI: 10.1038/369565a0

PubMed ID: 8020099

Title: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.

PubMed ID: 8020099

DOI: 10.1016/0092-8674(94)90450-2

PubMed ID: 7849319

Title: Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin.

PubMed ID: 7849319

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22284746

Title: Diurnal expression of the thrombopoietin gene is regulated by CLOCK.

PubMed ID: 22284746

DOI: 10.1111/j.1538-7836.2012.04643.x

Sequence Information:

  • Length: 356
  • Mass: 37836
  • Checksum: D346DBAE8392053C
  • Sequence:
    • MELTDLLLAA MLLAVARLTL SSPVAPACDP RLLNKLLRDS HLLHSRLSQC PDVDPLSIPV 
LLPAVDFSLG EWKTQTEQSK AQDILGAVSL LLEGVMAARG QLEPSCLSSL LGQLSGQVRL 
LLGALQGLLG TQLPLQGRTT AHKDPNALFL SLQQLLRGKV RFLLLVEGPT LCVRRTLPTT 
AVPSSTSQLL TLNKFPNRTS GLLETNFSVT ARTAGPGLLS RLQGFRVKIT PGQLNQTSRS 
PVQISGYLNR THGPVNGTHG LFAGTSLQTL EASDISPGAF NKGSLAFNLQ GGLPPSPSLA 
PDGHTPFPPS PALPTTHGSP PQLHPLFPDP STTMPNSTAP HPVTMYPHPR NLSQET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.