Genular: Defining Cellular Identity and Function

Details for: Thra

Gene ID: 21833

Symbol: Thra

Ensembl ID: ENSMUSG00000058756

Description: thyroid hormone receptor alpha

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Nuclear receptor transcription pathway
(R-MMU-383280)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Animal organ morphogenesis
(GO:0009887)
Cartilage condensation
(GO:0001502)
Cell differentiation
(GO:0030154)
Chromatin dna binding
(GO:0031490)
Cytosol
(GO:0005829)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Erythrocyte differentiation
(GO:0030218)
Female courtship behavior
(GO:0008050)
General transcription initiation factor binding
(GO:0140296)
Hormone-mediated signaling pathway
(GO:0009755)
Intronic transcription regulatory region sequence-specific dna binding
(GO:0001161)
Learning or memory
(GO:0007611)
Metal ion binding
(GO:0046872)
Mrna transcription by rna polymerase ii
(GO:0042789)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna-templated transcription initiation
(GO:2000143)
Negative regulation of rna polymerase ii transcription preinitiation complex assembly
(GO:0017055)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear receptor activity
(GO:0004879)
Nucleus
(GO:0005634)
Ossification
(GO:0001503)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of female receptivity
(GO:0045925)
Positive regulation of thyroid hormone mediated signaling pathway
(GO:0002157)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein homodimerization activity
(GO:0042803)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of heart contraction
(GO:0008016)
Regulation of lipid catabolic process
(GO:0050994)
Regulation of myeloid cell apoptotic process
(GO:0033032)
Regulation of thyroid hormone mediated signaling pathway
(GO:0002155)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to cold
(GO:0009409)
Retinoic acid receptor signaling pathway
(GO:0048384)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific dna binding
(GO:0043565)
Single-stranded rna binding
(GO:0003727)
Tbp-class protein binding
(GO:0017025)
Thyroid gland development
(GO:0030878)
Thyroid hormone binding
(GO:0070324)
Thyroid hormone mediated signaling pathway
(GO:0002154)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Type i pneumocyte differentiation
(GO:0060509)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Thyroid hormone receptor alpha

Genular Protein ID: 1687022736

Symbol: THA_MOUSE

Name: Thyroid hormone receptor alpha

UniProtKB Accession Codes:

P63058 A3KFN4 P10685 P15827 P16416 P37241 Q542U8 Q63107 Q63195 Q63196 Q80Y90 Q99146

Database IDs:

Citations:

PubMed ID: 3399404

Title: Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries.

PubMed ID: 3399404

DOI: 10.1093/nar/16.13.6248

PubMed ID: 2349106

Title: Nucleotide sequence of the murine thyroid hormone receptor (alpha-1) cDNA.

PubMed ID: 2349106

DOI: 10.1093/nar/18.10.3055

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9405624

Title: Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.

PubMed ID: 9405624

DOI: 10.1073/pnas.94.26.14400

PubMed ID: 10681503

Title: Cloning and characterization of RAP250, a nuclear receptor coactivator.

PubMed ID: 10681503

DOI: 10.1074/jbc.275.8.5308

PubMed ID: 16322094

Title: Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation.

PubMed ID: 16322094

DOI: 10.1210/me.2005-0074

PubMed ID: 20078863

Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.

PubMed ID: 20078863

DOI: 10.1186/1471-2199-11-3

PubMed ID: 20159955

Title: The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors.

PubMed ID: 20159955

DOI: 10.1101/gad.564110

Sequence Information:

Length: 492
Mass: 55023
Checksum: 870100FCB5C34A10
Sequence:

MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD EQCVVCGDKA 
TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM 
AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA 
QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS 
ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF 
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI 
PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQL 
GEAGSLRGPV LQHQSPKSPQ QRLLELLHRS GILHSRAVCG EDDSSEASSL SSSSDTEDTE 
VCEDQAGKAA SP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Thra

Associated with

Other Information

Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries. PubMed ID: 3399404

Nucleotide sequence of the murine thyroid hormone receptor (alpha-1) cDNA. PubMed ID: 2349106

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. PubMed ID: 9405624

Cloning and characterization of RAP250, a nuclear receptor coactivator. PubMed ID: 10681503

Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation. PubMed ID: 16322094

The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR. PubMed ID: 20078863

The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. PubMed ID: 20159955