Genular: Defining Cellular Identity and Function

Details for: Tie1

Gene ID: 21846

Symbol: Tie1

Ensembl ID: ENSMUSG00000033191

Description: tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Associated with

Angiogenesis
(GO:0001525)
Aortic valve morphogenesis
(GO:0003180)
Atp binding
(GO:0005524)
Blood vessel development
(GO:0001568)
Branching involved in lymph vessel morphogenesis
(GO:0060854)
In utero embryonic development
(GO:0001701)
Kinase activity
(GO:0016301)
Lymphatic endothelial cell differentiation
(GO:0060836)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of cell migration
(GO:0030336)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Plasma membrane fusion
(GO:0045026)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of kinase activity
(GO:0033674)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor complex
(GO:0043235)
Regulation of endothelial cell proliferation
(GO:0001936)
Regulation of extracellular matrix assembly
(GO:1901201)
Response to retinoic acid
(GO:0032526)
Tissue remodeling
(GO:0048771)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

Tyrosine-protein kinase receptor Tie-1

Genular Protein ID: 3495712446

Symbol: TIE1_MOUSE

Name: Tyrosine-protein kinase receptor Tie-1

UniProtKB Accession Codes:

Q06806 Q811F4 Q8BGI2

Database IDs:

Citations:

PubMed ID: 8415706

Title: Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

PubMed ID: 8415706

DOI: 10.1073/pnas.90.20.9355

PubMed ID: 8395828

Title: Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells.

PubMed ID: 8395828

DOI: 10.1006/bbrc.1993.2045

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7655012

Title: Endothelial-specific gene expression directed by the tie gene promoter in vivo.

PubMed ID: 7655012

PubMed ID: 1384789

Title: Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization.

PubMed ID: 1384789

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28179430

Title: Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.

PubMed ID: 28179430

DOI: 10.1161/circresaha.116.308825

Sequence Information:

Length: 1134
Mass: 124583
Checksum: 9669098A843B36F2
Sequence:

MVWWGSSLLL PTLFLASHVG ASVDLTLLAN LRITDPQRFF LTCVSGEAGA GRSSDPPLLL 
EKDDRIVRTF PPGQPLYLAR NGSHQVTLRG FSKPSDLVGV FSCVGGAGAR RTRVLYVHNS 
PGAHLFPDKV THTVNKGDTA VLSAHVHKEK QTDVIWKNNG SYFNTLDWQE ADDGRFQLQL 
QNVQPPSSGI YSATYLEASP LGSAFFRLIV RGCGAGRWGP GCVKDCPGCL HGGVCHDHDG 
ECVCPPGFTG TRCEQACREG RFGQSCQEQC PGTAGCRGLT FCLPDPYGCS CGSGWRGSQC 
QEACAPGHFG ADCRLQCQCQ NGGTCDRFSG CVCPSGWHGV HCEKSDRIPQ ILSMATEVEF 
NIGTMPRINC AAAGNPFPVR GSMKLRKPDG TMLLSTKVIV EPDRTTAEFE VPSLTLGDSG 
FWECRVSTSG GQDSRRFKVN VKVPPVPLTA PRLLAKQSRQ LVVSPLVSFS GDGPISSVRL 
HYRPQDSTIA WSAIVVDPSE NVTLMNLKPK TGYNVRVQLS RPGEGGEGGW GPSALMTTDC 
PEPLLQPWLE SWHVEGPDRL RVSWSLPSVP LSGDGFLLRL WDGARGQERR ENISFPQART 
ALLTGLTPGT HYQLDVRLYH CTLLGPASPP AHVHLPPSGP PAPRHLHAQA LSDSEIQLMW 
QHPEAPSGPI SKYIVEIQVA GGSGDPQWMD VDRPEETSII VRGLNASTRY LFRVRASVQG 
LGDWSNTVEE ATLGNGLQSE GPVRESRAAE EGLDQQLVLA VVGSVSATCL TILAALLALV 
CIRRSCLHRR RTFTYQSGSG EETILQFSSG TLTLTRRPKP QPEPLSYPVL EWEDITFEDL 
IGEGNFGQVI RAMIKKDGLK MNAAIKMLKE YASENDHRDF AGELEVLCKL GHHPNIINLL 
GACENRGYLY IAIEYAPYGN LLDFLRKSRV LETDPAFARE HGTASTLSSR QLLRFASDAA 
NGMQYLSEKQ FIHRDLAARN VLVGENLASK IADFGLSRGE EVYVKKTMGR LPVRWMAIES 
LNYSVYTTKS DVWSFGVLLW EIVSLGGTPY CGMTCAELYE KLPQGYRMEQ PRNCDDEVYE 
LMRQCWRDRP YERPPFAQIA LQLGRMLEAR KAYVNMSLFE NFTYAGIDAT AEEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tie1

Associated with

Other Information

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. PubMed ID: 8415706

Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells. PubMed ID: 8395828

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Endothelial-specific gene expression directed by the tie gene promoter in vivo. PubMed ID: 7655012

Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization. PubMed ID: 1384789

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. PubMed ID: 28179430