Genular: Defining Cellular Identity and Function

Details for: Timp1

Gene ID: 21857

Symbol: Timp1

Ensembl ID: ENSMUSG00000001131

Description: tissue inhibitor of metalloproteinase 1

Associated with

Activation of matrix metalloproteinases
(R-MMU-1592389)
Degradation of the extracellular matrix
(R-MMU-1474228)
Extracellular matrix organization
(R-MMU-1474244)
Hemostasis
(R-MMU-109582)
Metabolism of proteins
(R-MMU-392499)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Basement membrane
(GO:0005604)
Cellular response to uv-a
(GO:0071492)
Connective tissue replacement involved in inflammatory response wound healing
(GO:0002248)
Cytokine activity
(GO:0005125)
Enzyme inhibitor activity
(GO:0004857)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Metal ion binding
(GO:0046872)
Metalloendopeptidase inhibitor activity
(GO:0008191)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of catalytic activity
(GO:0043086)
Negative regulation of endopeptidase activity
(GO:0010951)
Negative regulation of membrane protein ectodomain proteolysis
(GO:0051045)
Negative regulation of metallopeptidase activity
(GO:1905049)
Negative regulation of peptidase activity
(GO:0010466)
Negative regulation of trophoblast cell migration
(GO:1901164)
Peptidase inhibitor activity
(GO:0030414)
Positive regulation of cell population proliferation
(GO:0008284)
Protease binding
(GO:0002020)
Regulation of integrin-mediated signaling pathway
(GO:2001044)
Response to cytokine
(GO:0034097)
Response to hormone
(GO:0009725)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Metalloproteinase inhibitor 1

Genular Protein ID: 602866704

Symbol: TIMP1_MOUSE

Name: Metalloproteinase inhibitor 1

UniProtKB Accession Codes:

P12032 P20064 Q61720

Database IDs:

Citations:

PubMed ID: 3034603

Title: Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus-induced gene in the mouse.

PubMed ID: 3034603

DOI: 10.1002/j.1460-2075.1987.tb04804.x

PubMed ID: 3024122

Title: A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: evidence for inducible and constitutive transcripts.

PubMed ID: 3024122

DOI: 10.1093/nar/14.22.8863

PubMed ID: 3670294

Title: Molecular cloning of gene sequences regulated by tumor promoters and mitogens through protein kinase C.

PubMed ID: 3670294

DOI: 10.1128/mcb.7.8.2821-2829.1987

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2744464

Title: Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development.

PubMed ID: 2744464

DOI: 10.1101/gad.3.6.848

PubMed ID: 6179042

Title: Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs.

PubMed ID: 6179042

DOI: 10.1093/nar/10.10.3069

PubMed ID: 23522389

Title: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation.

PubMed ID: 23522389

DOI: 10.1186/1476-4598-12-22

Sequence Information:

Length: 205
Mass: 22628
Checksum: FACA952D49A50FD7
Sequence:

MMAPFASLAS GILLLLSLIA SSKACSCAPP HPQTAFCNSD LVIRAKFMGS PEINETTLYQ 
RYKIKMTKML KGFKAVGNAA DIRYAYTPVM ESLCGYAHKS QNRSEEFLIT GRLRNGNLHI 
SACSFLVPWR TLSPAQQRAF SKTYSAGCGV CTVFPCLSIP CKLESDTHCL WTDQVLVGSE 
DYQSRHFACL PRNPGLCTWR SLGAR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Timp1

Associated with

Other Information

Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus-induced gene in the mouse. PubMed ID: 3034603

A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: evidence for inducible and constitutive transcripts. PubMed ID: 3024122

Molecular cloning of gene sequences regulated by tumor promoters and mitogens through protein kinase C. PubMed ID: 3670294

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development. PubMed ID: 2744464

Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs. PubMed ID: 6179042

Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. PubMed ID: 23522389