Genular: Defining Cellular Identity and Function

Details for: Timp3

Gene ID: 21859

Symbol: Timp3

Ensembl ID: ENSMUSG00000020044

Description: tissue inhibitor of metalloproteinase 3

Associated with

Hemostasis
(R-MMU-109582)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Basement membrane
(GO:0005604)
Cellular response to organic substance
(GO:0071310)
Enzyme inhibitor activity
(GO:0004857)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Mesenchymal cell differentiation involved in bone development
(GO:1901706)
Metal ion binding
(GO:0046872)
Metalloendopeptidase inhibitor activity
(GO:0008191)
Negative regulation of endopeptidase activity
(GO:0010951)
Negative regulation of membrane protein ectodomain proteolysis
(GO:0051045)
Negative regulation of metalloendopeptidase activity
(GO:1904684)
Negative regulation of peptidase activity
(GO:0010466)
Negative regulation of proteolysis
(GO:0045861)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Peptidase inhibitor activity
(GO:0030414)
Protease binding
(GO:0002020)
Response to cytokine
(GO:0034097)
Response to hormone
(GO:0009725)

Other Information

Proteins

Metalloproteinase inhibitor 3

Genular Protein ID: 860475509

Symbol: TIMP3_MOUSE

Name: Metalloproteinase inhibitor 3

UniProtKB Accession Codes:

P39876 Q91WL9

Database IDs:

Citations:

PubMed ID: 8132674

Title: Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

PubMed ID: 8132674

DOI: 10.1016/s0021-9258(17)37115-6

PubMed ID: 8118794

Title: Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3.

PubMed ID: 8118794

PubMed ID: 7949367

Title: Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10.

PubMed ID: 7949367

DOI: 10.1002/aja.1002000302

PubMed ID: 7642607

Title: Molecular cloning of mouse tissue inhibitor of metalloproteinases-3 and its promoter. Specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation.

PubMed ID: 7642607

DOI: 10.1074/jbc.270.33.19312

PubMed ID: 7782289

Title: The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family.

PubMed ID: 7782289

DOI: 10.1074/jbc.270.24.14313

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 211
Mass: 24182
Checksum: 184EDF5B8D69B07B
Sequence:

MTPWLGLVVL LSCWSLGHWG AEACTCSPSH PQDAFCNSDI VIRAKVVGKK LVKEGPFGTL 
VYTIKQMKMY RGFSKMPHVQ YIHTEASESL CGLKLEVNKY QYLLTGRVYE GKMYTGLCNF 
VERWDHLTLS QRKGLNYRYH LGCNCKIKSC YYLPCFVTSK NECLWTDMLS NFGYPGYQSK 
HYACIRQKGG YCSWYRGWAP PDKSISNATD P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Timp3

Associated with

Other Information

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. PubMed ID: 8132674

Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3. PubMed ID: 8118794

Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10. PubMed ID: 7949367

Molecular cloning of mouse tissue inhibitor of metalloproteinases-3 and its promoter. Specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation. PubMed ID: 7642607

The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family. PubMed ID: 7782289

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079