Genular: Defining Cellular Identity and Function

Details for: Nkx2 1

Gene ID: 21869

Symbol: Nkx2 1

Ensembl ID: ENSMUSG00000001496

Description: NK2 homeobox 1

Associated with

Anatomical structure formation involved in morphogenesis
(GO:0048646)
Animal organ morphogenesis
(GO:0009887)
Axon guidance
(GO:0007411)
Brain development
(GO:0007420)
Cell differentiation
(GO:0030154)
Cerebral cortex cell migration
(GO:0021795)
Cerebral cortex gabaergic interneuron differentiation
(GO:0021892)
Cerebral cortex neuron differentiation
(GO:0021895)
Club cell differentiation
(GO:0060486)
Core promoter sequence-specific dna binding
(GO:0001046)
Developmental induction
(GO:0031128)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Endoderm development
(GO:0007492)
Enzyme binding
(GO:0019899)
Feeding behavior
(GO:0007631)
Forebrain dorsal/ventral pattern formation
(GO:0021798)
Forebrain neuron differentiation
(GO:0021879)
Forebrain neuron fate commitment
(GO:0021877)
Gabaergic neuron differentiation
(GO:0097154)
Gene expression
(GO:0010467)
Globus pallidus development
(GO:0021759)
Hippocampus development
(GO:0021766)
Hypothalamus development
(GO:0021854)
Identical protein binding
(GO:0042802)
Interneuron migration
(GO:1904936)
Intronic transcription regulatory region sequence-specific dna binding
(GO:0001161)
Leydig cell differentiation
(GO:0033327)
Locomotory behavior
(GO:0007626)
Lung development
(GO:0030324)
Lung saccule development
(GO:0060430)
Menarche
(GO:0042696)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Neuron fate commitment
(GO:0048663)
Neuron migration
(GO:0001764)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oligodendrocyte differentiation
(GO:0048709)
Pattern specification process
(GO:0007389)
Phospholipid metabolic process
(GO:0006644)
Pituitary gland development
(GO:0021983)
Positive regulation of circadian rhythm
(GO:0042753)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of blood volume by renin-angiotensin
(GO:0002016)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to lipopolysaccharide
(GO:0032496)
Rhythmic process
(GO:0048511)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Tbp-class protein binding
(GO:0017025)
Telencephalon cell migration
(GO:0022029)
Telencephalon development
(GO:0021537)
Thyroid gland development
(GO:0030878)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator binding
(GO:0001221)
Transcription factor binding
(GO:0008134)
Transcription regulator complex
(GO:0005667)
Type ii pneumocyte differentiation
(GO:0060510)

Other Information

Proteins

Homeobox protein Nkx-2.1
Q6PFE0_MOUSE

Genular Protein ID: 532228704

Symbol: NKX21_MOUSE

Name: Homeobox protein Nkx-2.1

UniProtKB Accession Codes:

P50220

Database IDs:

Citations:

PubMed ID: 7711079

Title: The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: extensive identity of the deduced amino acid sequence with the human protein.

PubMed ID: 7711079

DOI: 10.1016/0167-4781(95)00033-d

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22955271

Title: The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.

PubMed ID: 22955271

DOI: 10.1074/jbc.m112.408401

PubMed ID: 22356123

Title: Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression.

PubMed ID: 22356123

DOI: 10.1111/j.1365-2826.2012.02302.x

Sequence Information:

Length: 372
Mass: 38570
Checksum: 377B5CE9B709412F
Sequence:

MSMSPKHTTP FSVSDILSPL EESYKKVGME GGGLGAPLAA YRQGQAAPPA AAMQQHAVGH 
HGAVTAAYHM TAAGVPQLSH SAVGGYCNGN LGNMSELPPY QDTMRNSASG PGWYGANPDP 
RFPAISRFMG PASGMNMSGM GGLGSLGDVS KNMAPLPSAP RRKRRVLFSQ AQVYELERRF 
KQQKYLSAPE REHLASMIHL TPTQVKIWFQ NHRYKMKRQA KDKAAQQQLQ QDSGGGGGGG 
GGAGCPQQQQ AQQQSPRRVA VPVLVKDGKP CQAGAPAPGA ASLQSHAQQQ AQQQAQAAQA 
AAAAISVGSG GAGLGAHPGH QPGSAGQSPD LAHHAASPAG LQGQVSSLSH LNSSGSDYGA 
MSCSTLLYGR TW

Genular Protein ID: 3460911126

Symbol: Q6PFE0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6PFE0

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 372
Mass: 38612
Checksum: 377B5CF8A609503E
Sequence:

MSMSPKHTTP FSVSDILSPL EESYKKVGME GGGLGAPLAA YRQGQAAPPA AAMQQHAVGH 
HGAVTAAYHM TAAGVPQLSH SAVGGYCNGN LGNMSELPPY QDTMRNSASG PGWYGANPDP 
RFPAISRFMG PASGMNMSGM GGLGSLGDVS KNMAPLPSAP RRKRRVLFSQ AQVYELERRF 
KQQKYLSAPE REHLASMIHL TPTQVKIWFQ NHRYKMKRQA KDKAAQQQLQ QDSGGGGGGG 
GGAGCPQQQQ AQQQSPRRVA VPVLVKDGKP CQAGAPAPGA ASLQSHAQQQ AQQQAQAAQA 
AAAAISVGSG GAVLGAHPGH QPGSAGQSPD LAHHAASPAG LQGQVSSLSH LNSSGSDYGA 
MSCSTLLYGR TW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nkx2 1

Associated with

Other Information

The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: extensive identity of the deduced amino acid sequence with the human protein. PubMed ID: 7711079

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. PubMed ID: 22955271

Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression. PubMed ID: 22356123

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Database document:

PubMed ID: 7711079

PubMed ID: 15489334

PubMed ID: 22955271

PubMed ID: 22356123

PubMed ID: 15489334