Genular: Defining Cellular Identity and Function

Details for: Atp6v0a2

Gene ID: 21871

Symbol: Atp6v0a2

Ensembl ID: ENSMUSG00000038023

Description: ATPase, H+ transporting, lysosomal V0 subunit A2

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Insulin receptor recycling
(R-MMU-77387)
Ion channel transport
(R-MMU-983712)
Iron uptake and transport
(R-MMU-917937)
Ros and rns production in phagocytes
(R-MMU-1222556)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Transferrin endocytosis and recycling
(R-MMU-917977)
Transport of small molecules
(R-MMU-382551)
Acrosomal vesicle
(GO:0001669)
Atpase binding
(GO:0051117)
Cellular response to increased oxygen levels
(GO:0036295)
Endosome
(GO:0005768)
Focal adhesion
(GO:0005925)
Intracellular iron ion homeostasis
(GO:0006879)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular organelle
(GO:0043229)
Membrane
(GO:0016020)
Monoatomic ion transport
(GO:0006811)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Proton-transporting atpase activity, rotational mechanism
(GO:0046961)
Proton-transporting v-type atpase, v0 domain
(GO:0033179)
Proton-transporting v-type atpase complex
(GO:0033176)
Proton transmembrane transport
(GO:1902600)
Transmembrane transporter complex
(GO:1902495)
Vacuolar acidification
(GO:0007035)
Vacuolar proton-transporting v-type atpase, v0 domain
(GO:0000220)
Vacuolar proton-transporting v-type atpase complex
(GO:0016471)

Other Information

Proteins

V-type proton ATPase 116 kDa subunit a 2

Genular Protein ID: 2790465522

Symbol: VPP2_MOUSE

Name: V-type proton ATPase 116 kDa subunit a 2

UniProtKB Accession Codes:

P15920 A4FU82 Q3U2X3 Q8VHU0 Q9JHJ2

Database IDs:

Citations:

PubMed ID: 2247090

Title: Cloning of a cDNA for a T cell produced molecule with a putative immune regulatory role.

PubMed ID: 2247090

DOI: 10.1016/0161-5890(90)90102-6

PubMed ID: 10722719

Title: Three subunit a isoforms of mouse vacuolar H+-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation.

PubMed ID: 10722719

DOI: 10.1074/jbc.275.12.8760

PubMed ID: 10702241

Title: Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase.

PubMed ID: 10702241

DOI: 10.1074/jbc.275.10.6824

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11375395

Title: A novel secreted form of immune suppressor factor with high homology to vacuolar ATPases identified by a forward genetic approach of functional screening based on cell proliferation.

PubMed ID: 11375395

DOI: 10.1074/jbc.m101781200

PubMed ID: 16415858

Title: V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.

PubMed ID: 16415858

DOI: 10.1038/ncb1348

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 856
Mass: 98145
Checksum: 6A0D593F6F401E22
Sequence:

MGSLFRSESM CLAQLFLQSG TAYECLSALG EKGLVQFRDL NQNVSSFQRK FVGEVKRCEE 
LERILVYLVQ EITRADIPLP EGEASPPAPP LKHVLEMQEQ LQKLEVELRE VTKNKEKLRK 
NLLELVEYTH MLRVTKTFLK RNVEFEPTYE EFPALENDSL LDYSCMQRLG AKLGFVSGLI 
QQGRVEAFER MLWRACKGYT IVTYAELDEC LEDPETGEVI KWYVFLISFW GEQIGHKVKK 
ICDCYHCHIY PYPNTAEERR EIQEGLNTRI QDLYTVLHKT EDYLRQVLCK AAESVCSRVV 
QVRKMKAIYH MLNMCSFDVT NKCLIAEVWC PEVDLPGLRR ALEEGSRESG ATIPSFMNTI 
PTKETPPTLI RTNKFTEGFQ NIVDAYGVGS YREVNPALFT IITFPFLFAV MFGDFGHGFV 
MFLFALLLVL NENHPRLSQS QEILRMFFDG RYILLLMGLF SVYTGLIYND CFSKSVNLFG 
SGWNVSAMYS SSHSPEEQRK MVLWNDSTIR HSRTLQLDPN IPGVFRGPYP FGIDPIWNLA 
TNRLTFLNSF KMKMSVILGI FHMTFGVVLG IFNHLHFRKK FNVYLVSVPE ILFMLCIFGY 
LIFMIIYKWL AYSAETSREA PSILIEFINM FLFPTSKTHG LYPGQAHVQR VLVALTVLAV 
PVLFLGKPLF LLWLHNGRNC FGMSRSGYTL VRKDSEEEVS LLGNQDIEEG NSRMEEGCRE 
VTCEEFNFGE ILMTQAIHSI EYCLGCISNT ASYLRLWALS LAHAQLSDVL WAMLMRVGLR 
VDTTYGVLLL LPVMAFFAVL TIFILLVMEG LSAFLHAIRL HWVEFQNKFY VGAGTKFVPF 
SFSLLSSKFS NDDSIA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Atp6v0a2

Associated with

Other Information

Cloning of a cDNA for a T cell produced molecule with a putative immune regulatory role. PubMed ID: 2247090

Three subunit a isoforms of mouse vacuolar H+-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation. PubMed ID: 10722719

Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase. PubMed ID: 10702241

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel secreted form of immune suppressor factor with high homology to vacuolar ATPases identified by a forward genetic approach of functional screening based on cell proliferation. PubMed ID: 11375395

V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway. PubMed ID: 16415858

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079