Genular: Defining Cellular Identity and Function

Details for: Tlr1

Gene ID: 21897

Symbol: Tlr1

Ensembl ID: ENSMUSG00000044827

Description: toll-like receptor 1

Associated with

Antimicrobial peptides
(R-MMU-6803157)
Beta defensins
(R-MMU-1461957)
Defensins
(R-MMU-1461973)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Regulation of tlr by endogenous ligand
(R-MMU-5686938)
Toll-like receptor cascades
(R-MMU-168898)
Activation of nf-kappab-inducing kinase activity
(GO:0007250)
Cellular response to triacyl bacterial lipopeptide
(GO:0071727)
Cytoplasmic vesicle
(GO:0031410)
Defense response
(GO:0006952)
Detection of triacyl bacterial lipopeptide
(GO:0042495)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Lipopeptide binding
(GO:0071723)
Macrophage activation
(GO:0042116)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Microglial cell activation
(GO:0001774)
Phagocytic vesicle
(GO:0045335)
Plasma membrane
(GO:0005886)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of toll-like receptor 2 signaling pathway
(GO:0034137)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Receptor complex
(GO:0043235)
Response to bacterial lipoprotein
(GO:0032493)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Toll-like receptor 1-toll-like receptor 2 protein complex
(GO:0035354)
Toll-like receptor 2 binding
(GO:0035663)
Toll-like receptor signaling pathway
(GO:0002224)
Transmembrane signaling receptor activity
(GO:0004888)
Triacyl lipopeptide binding
(GO:0042497)

Other Information

Proteins

Toll-like receptor 1

Genular Protein ID: 3379666423

Symbol: TLR1_MOUSE

Name: Toll-like receptor 1

UniProtKB Accession Codes:

Q9EPQ1 Q9EPW5

Database IDs:

Citations:

PubMed ID: 11095740

Title: The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors.

PubMed ID: 11095740

DOI: 10.1073/pnas.250476497

PubMed ID: 11123271

Title: Functional interactions between Toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.

PubMed ID: 11123271

DOI: 10.4049/jimmunol.166.1.15

PubMed ID: 17998391

Title: A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses.

PubMed ID: 17998391

DOI: 10.1084/jem.20071132

PubMed ID: 19362712

Title: TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.

PubMed ID: 19362712

DOI: 10.1016/j.cellimm.2009.03.008

Sequence Information:

Length: 795
Mass: 90673
Checksum: 855356429872D232
Sequence:

MTKPNSLIFY CIIVLGLTLM KIQLSEECEL IIKRPNANLT RVPKDLPLQT TTLDLSQNNI 
SELQTSDILS LSKLRVLIMS YNRLQYLNIS VFKFNTELEY LDLSHNELKV ILCHPTVSLK 
HLDLSFNAFD ALPICKEFGN MSQLQFLGLS GSRVQSSSVQ LIAHLNISKV LLVLGDAYGE 
KEDPESLRHV STETLHIVFP SKREFRFLLD VSVSTTIGLE LSNIKCVLED QGCSYFLRAL 
SKLGKNLKLS NLTLNNVETT WNSFINILQI VWHTPVKYFS ISNVKLQGQL AFRMFNYSDT 
SLKALSIHQV VTDVFSFPQS YIYSIFANMN IQNFTMSGTH MVHMLCPSQV SPFLHVDFTD 
NLLTDMVFKD CRNLVRLKTL SLQKNQLKNL ENIILTSAKM TSLQKLDISQ NSLRYSDGGI 
PCAWTQSLLV LNLSSNMLTG SVFRCLPPKV KVLDLHNNRI MSIPKDVTHL QALQELNVAS 
NSLTDLPGCG AFSSLSVLVI DHNSVSHPSE DFFQSCQNIR SLTAGNNPFQ CTCELRDFVK 
NIGWVAREVV EGWPDSYRCD YPESSRGTAL RDFHMSPLSC DTVLLTVTIG ATMLVLAVTG 
AFLCLYFDLP WYVRMLCQWT QTRHRARHIP LEELQRNLQF HAFVSYSGHD SAWVKNELLP 
NLEKDDIQIC LHERNFVPGK SIVENIINFI EKSYKSIFVL SPHFIQSEWC HYELYFAHHN 
LFHEGSDNLI LILLAPIPQY SIPTNYHKLK TLMSRRTYLE WPTEKNKHGL FWANLRASIN 
VKLVNQAEGT CYTQQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tlr1

Associated with

Other Information

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. PubMed ID: 11095740

Functional interactions between Toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. PubMed ID: 11123271

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses. PubMed ID: 17998391

TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. PubMed ID: 19362712

Database document:

PubMed ID: 11095740

PubMed ID: 11123271

PubMed ID: 17998391

PubMed ID: 19362712