Genular: Defining Cellular Identity and Function

Details for: Tlr4

Gene ID: 21898

Symbol: Tlr4

Ensembl ID: ENSMUSG00000039005

Description: toll-like receptor 4

Associated with

Activation of irf3, irf7 mediated by tbk1, ikbke
(R-MMU-936964)
Apoptosis
(R-MMU-109581)
Caspase activation via death receptors in the presence of ligand
(R-MMU-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-MMU-5357769)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Heme signaling
(R-MMU-9707616)
Ikk complex recruitment mediated by rip1
(R-MMU-937041)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Irak2 mediated activation of tak1 complex upon tlr7/8 or 9 stimulation
(R-MMU-975163)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Programmed cell death
(R-MMU-5357801)
Regulation of tlr by endogenous ligand
(R-MMU-5686938)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Traf6-mediated induction of tak1 complex within tlr4 complex
(R-MMU-937072)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Trif-mediated programmed cell death
(R-MMU-2562578)
Activation of innate immune response
(GO:0002218)
Activation of nf-kappab-inducing kinase activity
(GO:0007250)
Astrocyte development
(GO:0014002)
B cell proliferation involved in immune response
(GO:0002322)
Detection of lipopolysaccharide
(GO:0032497)
Gene expression
(GO:0010467)
I-kappab phosphorylation
(GO:0007252)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response-activating signaling pathway
(GO:0002758)
Interferon-beta production
(GO:0032608)
Interleukin-6 production
(GO:0032635)
Interleukin-10 production
(GO:0032613)
Jnk cascade
(GO:0007254)
Leukotriene metabolic process
(GO:0006691)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lipopolysaccharide binding
(GO:0001530)
Lipopolysaccharide immune receptor activity
(GO:0001875)
Macrophage cytokine production
(GO:0010934)
Microglia differentiation
(GO:0014004)
Microglial cell activation
(GO:0001774)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of interleukin-23 production
(GO:0032707)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Negative regulation of type ii interferon production
(GO:0032689)
Neurogenesis
(GO:0022008)
Nitric oxide biosynthetic process
(GO:0006809)
Nitric oxide production involved in inflammatory response
(GO:0002537)
Phagocytosis
(GO:0006909)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of platelet activation
(GO:0010572)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of dendritic cell cytokine production
(GO:0002730)
Regulation of tumor necrosis factor production
(GO:0032680)
Response to bacterium
(GO:0009617)
Response to lipopolysaccharide
(GO:0032496)
Response to oxidative stress
(GO:0006979)
Signaling receptor activity
(GO:0038023)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Toll-like receptor signaling pathway
(GO:0002224)
Transmembrane signaling receptor activity
(GO:0004888)
Tumor necrosis factor production
(GO:0032640)
Type ii interferon production
(GO:0032609)
Wound healing involved in inflammatory response
(GO:0002246)

Other Information

Proteins

Toll-like receptor 4

Genular Protein ID: 1756570482

Symbol: TLR4_MOUSE

Name: Toll-like receptor 4

UniProtKB Accession Codes:

Q9QUK6 Q9D691 Q9QZF5 Q9Z203

Database IDs:

Citations:

PubMed ID: 10087992

Title: Genetic and physical mapping of the Lps locus: identification of the Toll-4 receptor as a candidate gene in the critical region.

PubMed ID: 10087992

DOI: 10.1006/bcmd.1998.0201

PubMed ID: 9851930

Title: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

PubMed ID: 9851930

DOI: 10.1126/science.282.5396.2085

PubMed ID: 9989976

Title: Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4).

PubMed ID: 9989976

DOI: 10.1084/jem.189.4.615

PubMed ID: 10548109

Title: The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

PubMed ID: 10548109

DOI: 10.1038/44605

PubMed ID: 11104518

Title: Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4).

PubMed ID: 11104518

DOI: 10.1186/gb-2000-1-1-research002

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10952994

Title: Murine Toll-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase.

PubMed ID: 10952994

DOI: 10.1074/jbc.m007386200

PubMed ID: 17478729

Title: Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity.

PubMed ID: 17478729

DOI: 10.1161/circresaha.106.142851

PubMed ID: 18780723

Title: A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors.

PubMed ID: 18780723

DOI: 10.1093/intimm/dxn098

PubMed ID: 20133493

Title: Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.

PubMed ID: 20133493

DOI: 10.1093/intimm/dxq005

PubMed ID: 20865800

Title: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone.

PubMed ID: 20865800

DOI: 10.1038/ncomms1070

PubMed ID: 20037584

Title: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

PubMed ID: 20037584

DOI: 10.1038/ni.1836

PubMed ID: 22496641

Title: CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex.

PubMed ID: 22496641

DOI: 10.1371/journal.ppat.1002597

PubMed ID: 23812099

Title: CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.

PubMed ID: 23812099

DOI: 10.1038/ni.2639

PubMed ID: 24380872

Title: The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.

PubMed ID: 24380872

DOI: 10.1093/intimm/dxt071

PubMed ID: 26095358

Title: The lipid-modifying enzyme SMPDL3B negatively regulates innate immunity.

PubMed ID: 26095358

DOI: 10.1016/j.celrep.2015.05.006

PubMed ID: 25736436

Title: WDFY1 mediates TLR3/4 signaling by recruiting TRIF.

PubMed ID: 25736436

DOI: 10.15252/embr.201439637

PubMed ID: 28098138

Title: SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages.

PubMed ID: 28098138

DOI: 10.1038/ncomms14133

PubMed ID: 35896747

Title: Secreted fungal virulence effector triggers allergic inflammation via TLR4.

PubMed ID: 35896747

DOI: 10.1038/s41586-022-05005-4

PubMed ID: 17803912

Title: Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.

PubMed ID: 17803912

DOI: 10.1016/j.cell.2007.08.002

PubMed ID: 22532668

Title: Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.

PubMed ID: 22532668

DOI: 10.1073/pnas.1201193109

Sequence Information:

Length: 835
Mass: 95519
Checksum: 9C83B59F9A220C17
Sequence:

MMPPWLLART LIMALFFSCL TPGSLNPCIE VVPNITYQCM DQKLSKVPDD IPSSTKNIDL 
SFNPLKILKS YSFSNFSELQ WLDLSRCEIE TIEDKAWHGL HHLSNLILTG NPIQSFSPGS 
FSGLTSLENL VAVETKLASL ESFPIGQLIT LKKLNVAHNF IHSCKLPAYF SNLTNLVHVD 
LSYNYIQTIT VNDLQFLREN PQVNLSLDMS LNPIDFIQDQ AFQGIKLHEL TLRGNFNSSN 
IMKTCLQNLA GLHVHRLILG EFKDERNLEI FEPSIMEGLC DVTIDEFRLT YTNDFSDDIV 
KFHCLANVSA MSLAGVSIKY LEDVPKHFKW QSLSIIRCQL KQFPTLDLPF LKSLTLTMNK 
GSISFKKVAL PSLSYLDLSR NALSFSGCCS YSDLGTNSLR HLDLSFNGAI IMSANFMGLE 
ELQHLDFQHS TLKRVTEFSA FLSLEKLLYL DISYTNTKID FDGIFLGLTS LNTLKMAGNS 
FKDNTLSNVF ANTTNLTFLD LSKCQLEQIS WGVFDTLHRL QLLNMSHNNL LFLDSSHYNQ 
LYSLSTLDCS FNRIETSKGI LQHFPKSLAF FNLTNNSVAC ICEHQKFLQW VKEQKQFLVN 
VEQMTCATPV EMNTSLVLDF NNSTCYMYKT IISVSVVSVI VVSTVAFLIY HFYFHLILIA 
GCKKYSRGES IYDAFVIYSS QNEDWVRNEL VKNLEEGVPR FHLCLHYRDF IPGVAIAANI 
IQEGFHKSRK VIVVVSRHFI QSRWCIFEYE IAQTWQFLSS RSGIIFIVLE KVEKSLLRQQ 
VELYRLLSRN TYLEWEDNPL GRHIFWRRLK NALLDGKASN PEQTAEEEQE TATWT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tlr4

Associated with

Other Information

Genetic and physical mapping of the Lps locus: identification of the Toll-4 receptor as a candidate gene in the critical region. PubMed ID: 10087992

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. PubMed ID: 9851930

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). PubMed ID: 9989976

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. PubMed ID: 10548109

Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4). PubMed ID: 11104518

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Murine Toll-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. PubMed ID: 10952994

Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. PubMed ID: 17478729

A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors. PubMed ID: 18780723

Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. PubMed ID: 20133493

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. PubMed ID: 20865800

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. PubMed ID: 20037584

CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PubMed ID: 22496641

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. PubMed ID: 23812099

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. PubMed ID: 24380872

The lipid-modifying enzyme SMPDL3B negatively regulates innate immunity. PubMed ID: 26095358

WDFY1 mediates TLR3/4 signaling by recruiting TRIF. PubMed ID: 25736436

SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. PubMed ID: 28098138

Secreted fungal virulence effector triggers allergic inflammation via TLR4. PubMed ID: 35896747

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. PubMed ID: 17803912

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. PubMed ID: 22532668