Details for: Tlr6

Gene ID: 21899

Symbol: Tlr6

Ensembl ID: ENSMUSG00000051498

Description: toll-like receptor 6

Associated with

  • Immune system
    (R-MMU-168256)
  • Innate immune system
    (R-MMU-168249)
  • Regulation of tlr by endogenous ligand
    (R-MMU-5686938)
  • Toll-like receptor cascades
    (R-MMU-168898)
  • Cellular response to amyloid-beta
    (GO:1904646)
  • Cellular response to diacyl bacterial lipopeptide
    (GO:0071726)
  • Cellular response to oxidised low-density lipoprotein particle stimulus
    (GO:0140052)
  • Cytoplasmic vesicle
    (GO:0031410)
  • Detection of diacyl bacterial lipopeptide
    (GO:0042496)
  • Diacyl lipopeptide binding
    (GO:0042498)
  • Golgi apparatus
    (GO:0005794)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Immune system process
    (GO:0002376)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Lipopeptide binding
    (GO:0071723)
  • Membrane
    (GO:0016020)
  • Membrane raft
    (GO:0045121)
  • Microglial cell activation
    (GO:0001774)
  • Myd88-dependent toll-like receptor signaling pathway
    (GO:0002755)
  • Negative regulation of interleukin-8 production
    (GO:0032717)
  • Negative regulation of toll-like receptor 2 signaling pathway
    (GO:0034136)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Nitric oxide metabolic process
    (GO:0046209)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cytokine production involved in inflammatory response
    (GO:1900017)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of jun kinase activity
    (GO:0043507)
  • Positive regulation of macrophage activation
    (GO:0043032)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of nlrp3 inflammasome complex assembly
    (GO:1900227)
  • Positive regulation of reactive oxygen species biosynthetic process
    (GO:1903428)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Receptor complex
    (GO:0043235)
  • Response to bacterial lipoprotein
    (GO:0032493)
  • Signaling receptor activity
    (GO:0038023)
  • Signaling receptor binding
    (GO:0005102)
  • Signal transduction
    (GO:0007165)
  • Toll-like receptor 2 binding
    (GO:0035663)
  • Toll-like receptor 2-toll-like receptor 6 protein complex
    (GO:0035355)
  • Toll-like receptor signaling pathway
    (GO:0002224)
  • Toll-like receptor tlr6:tlr2 signaling pathway
    (GO:0038124)
  • Transmembrane signaling receptor activity
    (GO:0004888)
  • Trif-dependent toll-like receptor signaling pathway
    (GO:0035666)

Other Information

Genular Protein ID: 3027587792

Symbol: TLR6_MOUSE

Name: Toll-like receptor 6

UniProtKB Accession Codes:

Q9EPW9 Q9WTQ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEMBL 1 DNASU 1 EMBL 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 2 GeneTree 1 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 5 SMART 3 SMR 1 STRING 1 SUPFAM 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10231569

Title: TLR6: a novel member of an expanding Toll-like receptor family.

PubMed ID: 10231569

DOI: 10.1016/s0378-1119(99)00098-0

PubMed ID: 11095740

Title: The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors.

PubMed ID: 11095740

DOI: 10.1073/pnas.250476497

PubMed ID: 20037584

Title: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

PubMed ID: 20037584

DOI: 10.1038/ni.1836

PubMed ID: 23812099

Title: CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.

PubMed ID: 23812099

DOI: 10.1038/ni.2639

PubMed ID: 19931471

Title: Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.

PubMed ID: 19931471

DOI: 10.1016/j.immuni.2009.09.018

Sequence Information:

  • Length: 795
  • Mass: 91116
  • Checksum: 34D8BD175A26C233
  • Sequence:
    • MSQDRKPIVG SFHFVCALAL IVGSMTPFSN ELESMVDYSN RNLTHVPKDL PPRTKALSLS 
QNSISELRMP DISFLSELRV LRLSHNRIRS LDFHVFLFNQ DLEYLDVSHN RLQNISCCPM 
ASLRHLDLSF NDFDVLPVCK EFGNLTKLTF LGLSAAKFRQ LDLLPVAHLH LSCILLDLVS 
YHIKGGETES LQIPNTTVLH LVFHPNSLFS VQVNMSVNAL GHLQLSNIKL NDENCQRLMT 
FLSELTRGPT LLNVTLQHIE TTWKCSVKLF QFFWPRPVEY LNIYNLTITE RIDREEFTYS 
ETALKSLMIE HVKNQVFLFS KEALYSVFAE MNIKMLSISD TPFIHMVCPP SPSSFTFLNF 
TQNVFTDSVF QGCSTLKRLQ TLILQRNGLK NFFKVALMTK NMSSLETLDV SLNSLNSHAY 
DRTCAWAESI LVLNLSSNML TGSVFRCLPP KVKVLDLHNN RIMSIPKDVT HLQALQELNV 
ASNSLTDLPG CGAFSSLSVL VIDHNSVSHP SEDFFQSCQN IRSLTAGNNP FQCTCELRDF 
VKNIGWVARE VVEGWPDSYR CDYPESSKGT ALRDFHMSPL SCDTVLLTVT IGATMLVLAV 
TGAFLCLYFD LPWYVRMLCQ WTQTRHRARH IPLEELQRNL QFHAFVSYSE HDSAWVKNEL 
LPNLEKDDIR VCLHERNFVP GKSIVENIIN FIEKSYKAIF VLSPHFIQSE WCHYELYFAH 
HNLFHEGSDN LILILLEPIL QNNIPSRYHK LRALMAQRTY LEWPTEKGKR GLFWANLRAS 
FIMKLALVNE DDVKT

Genular Protein ID: 253238378

Symbol: Q3UV88_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UV88

Database IDs:

AGR 1 ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 22 Gene3D 2 GeneTree 1 HOGENOM 1 InterPro 7 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PRINTS 1 PROSITE 3 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 5 SAM 1 SMART 3 SMR 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 806
  • Mass: 92394
  • Checksum: 6FD0CD4CB8FA5741
  • Sequence:
    • MVKSLWDSLC NMSQDRKPIV GSFHFVCALA LIVGSMTPFS NELESMVDYS NRNLTHVPKD 
LPPRTKALSL SQNSISELRM PDISFLSELR VLRLSHNRIR SLDFHVFLFN QDLEYLDVSH 
NRLQNISCCP MASLRHLDLS FNDFDVLPVC KEFGNLTKLT FLGLSAAKFR QLDLLPVAHL 
HLSCILLDLV SYHIKGGETE SLQIPNTTVL HLVFHPNSLF SVQVNMSVNA LGHLQLSNIK 
LNDENCQRLM TFLSELTRGP TLLNVTLQHI ETTWKCSVKL FQFFWPRPVE YLNIYNLTIT 
ERIDREEFTY SETALKSLMI EHVKNQVFLF SKEALYSVFA EMNIKMLSIS DTPFIHMVCP 
PSPSSFTFLN FTQNVFTDSV FQGCSTLKRL QTLILQRNGL KNFFKVALMT KNMSSLETLD 
VSLNSLNSHA YDRTCAWAES ILVLNLSSNM LTGSVFRCLP PKVKVLDLHN NRIMSIPKDV 
THLQALQELN VASNSLTDLP GCGAFSSLSV LVIDHNSVSH PSEDFFQSCQ NIRSLTAGNN 
PFQCTCELRD FVKNIGWVAR EVVEGWPDSY RCDYPESSKG TALRDFHMSP LSCDTVLLTV 
TIGATMLVLA VTGAFLCLYF DLPWYVRMLC QWTQTRHRAR HIPLEELQRN LQFHAFVSYS 
EHDSAWVKNE LLPNLEKDDI RVCLHERNFV PGKSIVENII NFIEKSYKAI FVLSPHFIQS 
EWCHYELYFA HHNLFHEGSD NLILILLEPI LQNNIPSRYH KLRALMAQRT YLEWPTEKGK 
RGLFWANLRA SFIMKLALVN EDDVKT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.