Details for: ALDH1B1

Gene ID: 219

Symbol: ALDH1B1

Ensembl ID: ENSG00000137124

Description: aldehyde dehydrogenase 1 family member B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.5
    Marker Score: 3593
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.37
    Marker Score: 3215
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.26
    Marker Score: 1356
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.2
    Marker Score: 2851
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48025
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.95
    Marker Score: 356
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14534
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.91
    Marker Score: 3244
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1463
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.89
    Marker Score: 336
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5274
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1659
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.71
    Marker Score: 203
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.7
    Marker Score: 2610
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 448
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7
    Marker Score: 1323
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 278
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.69
    Marker Score: 525.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 627
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.68
    Marker Score: 462
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1583
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2817
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.67
    Marker Score: 190
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.65
    Marker Score: 1360
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.6
    Marker Score: 639
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.59
    Marker Score: 626
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.59
    Marker Score: 472
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.59
    Marker Score: 186.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.57
    Marker Score: 1547
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.56
    Marker Score: 372
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.55
    Marker Score: 715
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.55
    Marker Score: 5518
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.55
    Marker Score: 139
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.54
    Marker Score: 403
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.53
    Marker Score: 125
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.53
    Marker Score: 1652
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.5
    Marker Score: 521
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.5
    Marker Score: 688
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.49
    Marker Score: 838
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.48
    Marker Score: 314
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 227
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.45
    Marker Score: 843
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 263
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.43
    Marker Score: 713
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.43
    Marker Score: 242.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.41
    Marker Score: 5443
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.41
    Marker Score: 2681
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.41
    Marker Score: 284
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 108
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.41
    Marker Score: 187
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.4
    Marker Score: 428
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.39
    Marker Score: 824.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.39
    Marker Score: 1668
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.38
    Marker Score: 1653.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.38
    Marker Score: 370
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.37
    Marker Score: 364
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.36
    Marker Score: 200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.36
    Marker Score: 150
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.36
    Marker Score: 180
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.35
    Marker Score: 438
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.35
    Marker Score: 608
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.34
    Marker Score: 75
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.33
    Marker Score: 317
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.32
    Marker Score: 130
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.32
    Marker Score: 298
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.31
    Marker Score: 1865
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.31
    Marker Score: 69
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3
    Marker Score: 114
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3
    Marker Score: 302
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.3
    Marker Score: 317
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.3
    Marker Score: 340
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.3
    Marker Score: 106
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.3
    Marker Score: 291
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.3
    Marker Score: 314
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.29
    Marker Score: 155
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.29
    Marker Score: 88
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.29
    Marker Score: 83
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.29
    Marker Score: 71
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.29
    Marker Score: 308
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.29
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.29
    Marker Score: 190
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.28
    Marker Score: 91
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.28
    Marker Score: 119
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.27
    Marker Score: 243
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.27
    Marker Score: 360
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.27
    Marker Score: 78
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.27
    Marker Score: 111

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Other Information

**Key characteristics:** - ALDH1B1 is a multi-functional enzyme that can act as an aldehyde dehydrogenase, a cytochrome P450 enzyme, and a NADPH-dependent isoform of the enzyme. - It is involved in a variety of cellular processes, including the metabolism of ethanol, fatty acids, and amino acids. - It is a key regulator of cellular metabolism and can be involved in the regulation of inflammation and cell death. **Pathways and functions:** - ALDH1B1 is involved in the metabolism of aldehydes and organic compounds in the cell. - It is involved in the detoxification of ethanol, which is a toxic metabolite that can damage liver cells. - It is also involved in the metabolism of fatty acids and amino acids, and in the synthesis of cholesterol. - It is a key regulator of cellular metabolism and can be involved in the regulation of inflammation and cell death. **Clinical significance:** - Mutations in ALDH1B1 have been linked to a number of human diseases, including liver disease, cancer, and neurodegenerative diseases. - ALDH1B1 inhibitors are being investigated as potential treatments for these diseases. **Conclusion:** ALDH1B1 is a key regulator of cellular metabolism that is involved in a variety of cellular processes, including the detoxification of ethanol, the metabolism of fatty acids and amino acids, and the synthesis of cholesterol. Mutations in ALDH1B1 have been linked to a number of human diseases, highlighting the importance of this gene in human health.

Genular Protein ID: 2827363330

Symbol: AL1B1_HUMAN

Name: Aldehyde dehydrogenase X, mitochondrial

UniProtKB Accession Codes:

P30837 B2R8F0 Q8WX76 Q9BV45

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2061311

Title: Cloning and characterization of a new functional human aldehyde dehydrogenase gene.

PubMed ID: 2061311

DOI: 10.1016/s0021-9258(18)98890-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8244338

Title: Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene.

PubMed ID: 8244338

DOI: 10.1007/bf00216454

Sequence Information:

  • Length: 517
  • Mass: 57249
  • Checksum: B877BD45FEC70025
  • Sequence:
    • MLRFLAPRLL SLQGRTARYS SAAALPSPIL NPDIPYNQLF INNEWQDAVS KKTFPTVNPT 
TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE RGRLLNRLAD LVERDRVYLA 
SLETLDNGKP FQESYALDLD EVIKVYRYFA GWADKWHGKT IPMDGQHFCF TRHEPVGVCG 
QIIPWNFPLV MQGWKLAPAL ATGNTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG 
YGPTAGAAIA QHVDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM 
EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN PFELDTQQGP 
QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP TVFGGVQDDM RIAKEEIFGP 
VQPLFKFKKI EEVVERANNT RYGLAAAVFT RDLDKAMYFT QALQAGTVWV NTYNIVTCHT 
PFGGFKESGN GRELGEDGLK AYTEVKTVTI KVPQKNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.