Details for: ALDH1B1

Gene ID: 219

Symbol: ALDH1B1

Ensembl ID: ENSG00000137124

Description: aldehyde dehydrogenase 1 family member B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.7897
    Cell Significance Index: -9.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 33.5116
    Cell Significance Index: -8.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.0366
    Cell Significance Index: -8.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.9101
    Cell Significance Index: -9.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 14.5748
    Cell Significance Index: -9.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.1187
    Cell Significance Index: -10.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5836
    Cell Significance Index: -9.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5899
    Cell Significance Index: -10.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7766
    Cell Significance Index: 106.6600
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.5821
    Cell Significance Index: 8.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3191
    Cell Significance Index: 1191.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2698
    Cell Significance Index: 34.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1924
    Cell Significance Index: 193.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7517
    Cell Significance Index: 51.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6919
    Cell Significance Index: 68.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5165
    Cell Significance Index: 5.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5158
    Cell Significance Index: 16.5200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4127
    Cell Significance Index: 3.3000
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.3788
    Cell Significance Index: 1.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3353
    Cell Significance Index: 9.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2719
    Cell Significance Index: 5.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2265
    Cell Significance Index: 10.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2050
    Cell Significance Index: 4.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2043
    Cell Significance Index: 38.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2032
    Cell Significance Index: 7.0600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1932
    Cell Significance Index: 5.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1350
    Cell Significance Index: 18.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1228
    Cell Significance Index: 24.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1198
    Cell Significance Index: 65.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1007
    Cell Significance Index: 7.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0923
    Cell Significance Index: 0.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0849
    Cell Significance Index: 2.1700
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.0604
    Cell Significance Index: 0.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0527
    Cell Significance Index: 23.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0441
    Cell Significance Index: 0.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0403
    Cell Significance Index: 1.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0120
    Cell Significance Index: 0.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0117
    Cell Significance Index: 0.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0070
    Cell Significance Index: 1.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0036
    Cell Significance Index: 0.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0006
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0032
    Cell Significance Index: -0.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0047
    Cell Significance Index: -0.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0065
    Cell Significance Index: -4.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0069
    Cell Significance Index: -5.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0108
    Cell Significance Index: -16.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0123
    Cell Significance Index: -16.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0125
    Cell Significance Index: -5.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0127
    Cell Significance Index: -8.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0131
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0152
    Cell Significance Index: -4.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0173
    Cell Significance Index: -1.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0190
    Cell Significance Index: -10.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0201
    Cell Significance Index: -3.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0203
    Cell Significance Index: -4.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0215
    Cell Significance Index: -7.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0264
    Cell Significance Index: -16.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0272
    Cell Significance Index: -0.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0340
    Cell Significance Index: -3.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0374
    Cell Significance Index: -4.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0392
    Cell Significance Index: -0.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0434
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0581
    Cell Significance Index: -12.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0615
    Cell Significance Index: -1.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0631
    Cell Significance Index: -9.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0681
    Cell Significance Index: -5.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0799
    Cell Significance Index: -3.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0859
    Cell Significance Index: -1.2200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0871
    Cell Significance Index: -0.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0903
    Cell Significance Index: -9.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0922
    Cell Significance Index: -5.8100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0948
    Cell Significance Index: -1.3300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0988
    Cell Significance Index: -0.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1015
    Cell Significance Index: -6.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1046
    Cell Significance Index: -6.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1115
    Cell Significance Index: -1.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1135
    Cell Significance Index: -5.9100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1197
    Cell Significance Index: -0.8700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1307
    Cell Significance Index: -6.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1322
    Cell Significance Index: -5.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1408
    Cell Significance Index: -8.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1449
    Cell Significance Index: -11.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1478
    Cell Significance Index: -4.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1548
    Cell Significance Index: -10.4100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1591
    Cell Significance Index: -2.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1611
    Cell Significance Index: -4.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1704
    Cell Significance Index: -2.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1720
    Cell Significance Index: -4.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1760
    Cell Significance Index: -9.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1764
    Cell Significance Index: -9.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1870
    Cell Significance Index: -3.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1978
    Cell Significance Index: -5.6700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1979
    Cell Significance Index: -2.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2010
    Cell Significance Index: -5.9200
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.2095
    Cell Significance Index: -1.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2188
    Cell Significance Index: -4.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ALDH1B1 is a mitochondrial enzyme that belongs to the aldehyde dehydrogenase family. It is a homodimeric enzyme composed of two identical subunits, each with a catalytic domain that is responsible for the oxidation of aldehydes to their corresponding carboxylic acids. ALDH1B1 is highly expressed in various tissues, including the respiratory system, enteric nervous system, and reproductive organs. Its expression is also observed in stem cells, which suggests its role in maintaining cellular pluripotency and differentiation. **Pathways and Functions:** ALDH1B1 is involved in several cellular pathways, including: 1. **Aldehyde detoxification**: ALDH1B1 plays a critical role in detoxifying aldehydes, which are toxic compounds that can cause oxidative stress and damage to cellular components. 2. **Metabolic regulation**: ALDH1B1 is involved in the regulation of carbohydrate metabolism, including the metabolism of glyceraldehyde-3-phosphate. 3. **Ethanol catabolism**: ALDH1B1 is responsible for the oxidation of ethanol, a key step in the metabolism of this toxic compound. 4. **Mitochondrial function**: ALDH1B1 is localized to the mitochondrial matrix and is involved in the regulation of mitochondrial protein degradation and the metabolism of mitochondrial proteins. **Clinical Significance:** ALDH1B1 has been implicated in various disease contexts, including: 1. **Alcoholic liver disease**: ALDH1B1 is highly expressed in the liver and plays a critical role in the detoxification of aldehydes, which are toxic compounds produced during ethanol metabolism. Deficiencies in ALDH1B1 have been associated with the development of alcoholic liver disease. 2. **Neurodegenerative diseases**: ALDH1B1 has been implicated in the pathology of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Its role in regulating carbohydrate metabolism and mitochondrial function suggests its potential involvement in the development of these diseases. 3. **Cancer**: ALDH1B1 has been found to be highly expressed in certain types of cancer, including lung, breast, and colon cancer. Its role in regulating cellular metabolism and detoxification suggests its potential as a biomarker for cancer diagnosis and treatment. In conclusion, ALDH1B1 is a critical enzyme involved in the regulation of cellular metabolism, detoxification, and immune function. Its clinical significance in various disease contexts highlights the importance of understanding its role in maintaining cellular homeostasis and its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 2827363330

Symbol: AL1B1_HUMAN

Name: Aldehyde dehydrogenase X, mitochondrial

UniProtKB Accession Codes:

P30837 B2R8F0 Q8WX76 Q9BV45

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2061311

Title: Cloning and characterization of a new functional human aldehyde dehydrogenase gene.

PubMed ID: 2061311

DOI: 10.1016/s0021-9258(18)98890-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8244338

Title: Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene.

PubMed ID: 8244338

DOI: 10.1007/bf00216454

Sequence Information:

  • Length: 517
  • Mass: 57249
  • Checksum: B877BD45FEC70025
  • Sequence:
    • MLRFLAPRLL SLQGRTARYS SAAALPSPIL NPDIPYNQLF INNEWQDAVS KKTFPTVNPT 
TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE RGRLLNRLAD LVERDRVYLA 
SLETLDNGKP FQESYALDLD EVIKVYRYFA GWADKWHGKT IPMDGQHFCF TRHEPVGVCG 
QIIPWNFPLV MQGWKLAPAL ATGNTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG 
YGPTAGAAIA QHVDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM 
EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN PFELDTQQGP 
QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP TVFGGVQDDM RIAKEEIFGP 
VQPLFKFKKI EEVVERANNT RYGLAAAVFT RDLDKAMYFT QALQAGTVWV NTYNIVTCHT 
PFGGFKESGN GRELGEDGLK AYTEVKTVTI KVPQKNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.