Details for: Otop1

Gene ID: 21906

Symbol: Otop1

Ensembl ID: ENSMUSG00000051596

Description: otopetrin 1

Associated with

Other Information

Genular Protein ID: 2491212912

Symbol: OTOP1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q80VM9 A0A0R4J1J4 E9QMU2 Q7M735 Q8BRZ4 Q8BS22

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 9 GeneTree 1 InParanoid 1 InterPro 1 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 TCDB 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 12651873

Title: Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.

PubMed ID: 12651873

DOI: 10.1093/hmg/ddg087

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 17606897

Title: Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium.

PubMed ID: 17606897

DOI: 10.1073/pnas.0705182104

PubMed ID: 20554841

Title: Regulation of cellular calcium in vestibular supporting cells by otopetrin 1.

PubMed ID: 20554841

DOI: 10.1152/jn.00525.2010

PubMed ID: 21236346

Title: Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells.

PubMed ID: 21236346

DOI: 10.1016/j.mcn.2011.01.005

PubMed ID: 24379350

Title: Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation.

PubMed ID: 24379350

DOI: 10.2337/db13-1139

PubMed ID: 29371428

Title: An evolutionarily conserved gene family encodes proton-selective ion channels.

PubMed ID: 29371428

DOI: 10.1126/science.aao3264

Sequence Information:

  • Length: 600
  • Mass: 65755
  • Checksum: CC10FA749803064B
  • Sequence:
    • MPGGPGAPSS PAASSGSSRA APSGIAACPL SPPPLARGSP QASGPRRGAS VPQKLAETLS 
SQYGLNVFVA GLLFLLAWAV HATGVGKSDL LCVLTALMLL QLLWMLWYVG RSYMQRRLIR 
PKDTHAGARW LRGSITLFAF ITVVLGCLKV AYFIGFSECL SATEGVFPVT HAVHTLLQVY 
FLWGHAKDII MSFKTLERFG VIHSVFTNLL LWANSVLNES KHQLNEHKER LITLGFGNIT 
IVLDDHTPQC NCTPPALCSA LSHGIYYLYP FNIEYQILAS TMLYVLWKNI GRRVDSSQHQ 
KMQCRFDGVL VGSVLGLTVL AATIAVVVVY MIHIGRSKSK SESALIMFYL YAITVLLLMG 
AAGLVGSWIY RVDEKSLDES KNPARKLDVD LLVATGSGSW LLSWGSILAI ACAETRPPYT 
WYNLPYSVLV IVEKYVQNIF IIESVHLEPE GVPEDVRTLR VVTVCSSEAA ALAASTLGSQ 
GMAQDGSPAV NGNLCLQQRC GKEDQESGWE GATGTTRCLD FLQGGMKRRL LRNITAFLFL 
CNISLWIPPA FGCRPEYDNG LEEIVFGFEP WIIVVNLAMP FSIFYRMHAA AALFEVYCKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.