Details for: Tlx2

Gene ID: 21909

Symbol: Tlx2

Ensembl ID: ENSMUSG00000068327

Description: T cell leukemia, homeobox 2

Associated with

  • Animal organ development
    (GO:0048513)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Enteric nervous system development
    (GO:0048484)
  • Mesoderm formation
    (GO:0001707)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of dendrite morphogenesis
    (GO:0050774)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Other Information

Genular Protein ID: 1284743671

Symbol: TLX2_MOUSE

Name: T-cell leukemia homeobox protein 2

UniProtKB Accession Codes:

Q61663 B2RR62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1681546

Title: HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

PubMed ID: 1681546

DOI: 10.1073/pnas.88.20.8900

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9176491

Title: Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon.

PubMed ID: 9176491

DOI: 10.1038/nm0697-646

PubMed ID: 10869550

Title: Identification of an optimal Ncx binding sequence required for transcriptional activation.

PubMed ID: 10869550

DOI: 10.1016/s0014-5793(00)01651-3

PubMed ID: 11176528

Title: Vesicourethral sphincter dysfunction in ncx deficient mice with an increased neuronal cell number in vesical ganglia.

PubMed ID: 11176528

DOI: 10.1097/00005392-200103000-00075

PubMed ID: 15185227

Title: Acetylcholine-related bowel dysmotility in homozygous mutant NCX/HOX11L.1-deficient (NCX-/-) mice-evidence that acetylcholine is implicated in causing intestinal neuronal dysplasia.

PubMed ID: 15185227

DOI: 10.1016/j.jpedsurg.2004.02.004

PubMed ID: 15803212

Title: Hox11L1 expression by precursors of enteric smooth muscle: an alternative explanation for megacecum in HOX11L1-/- mice.

PubMed ID: 15803212

DOI: 10.1007/s10024-005-1126-0

PubMed ID: 17560225

Title: Ncx (Enx, Hox11L.1) is required for neuronal cell death in enteric ganglia of mice.

PubMed ID: 17560225

DOI: 10.1016/j.jpedsurg.2007.01.064

PubMed ID: 19697050

Title: Immature enteric neurons in Ncx/Hox11L.1 deficient intestinal neuronal dysplasia model mice.

PubMed ID: 19697050

DOI: 10.1007/s00383-009-2451-6

Sequence Information:

  • Length: 284
  • Mass: 30361
  • Checksum: CD1D6D3EB0F8CBDA
  • Sequence:
    • MEPAVLAAHH LPHHEPISFG IDQILSGPEP PGGGLGPGQS GQSHGESAAF SSGFHGASGY 
APAGSLASLP RGSGVGPGGV IRVPAHRPLP VPPPSGAAPA VPGPSGLGGA GGLAGLTFPW 
MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ NRTPPKRKKP RTSFSRSQVL ELERRFLRQK 
YLASAERAAL AKALRMTDAQ VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP 
RPLRPPLPPD PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.