Details for: Tnf

Gene ID: 21926

Symbol: Tnf

Ensembl ID: ENSMUSG00000024401

Description: tumor necrosis factor

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Death receptor signaling
    (R-MMU-73887)
  • Immune system
    (R-MMU-168256)
  • Regulation of tnfr1 signaling
    (R-MMU-5357905)
  • Signal transduction
    (R-MMU-162582)
  • Tnfr1-induced nf-kappa-b signaling pathway
    (R-MMU-5357956)
  • Tnfr1-induced proapoptotic signaling
    (R-MMU-5357786)
  • Tnfr1-mediated ceramide production
    (R-MMU-5626978)
  • Tnfr2 non-canonical nf-kb pathway
    (R-MMU-5668541)
  • Tnf signaling
    (R-MMU-75893)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Animal organ morphogenesis
    (GO:0009887)
  • Calcium-mediated signaling
    (GO:0019722)
  • Chronic inflammatory response to antigenic stimulus
    (GO:0002439)
  • Cortical actin cytoskeleton organization
    (GO:0030866)
  • Cytokine activity
    (GO:0005125)
  • Death receptor agonist activity
    (GO:0038177)
  • Defense response
    (GO:0006952)
  • Extracellular matrix organization
    (GO:0030198)
  • Extrinsic apoptotic signaling pathway via death domain receptors
    (GO:0008625)
  • Glucose metabolic process
    (GO:0006006)
  • Humoral immune response
    (GO:0006959)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Interleukin-6 production
    (GO:0032635)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Jnk cascade
    (GO:0007254)
  • Macrophage activation involved in immune response
    (GO:0002281)
  • Microglial cell activation
    (GO:0001774)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of alkaline phosphatase activity
    (GO:0010693)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cytokine production involved in immune response
    (GO:0002719)
  • Negative regulation of endothelial cell proliferation
    (GO:0001937)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of heart rate
    (GO:0010459)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of l-glutamate import across plasma membrane
    (GO:0002037)
  • Negative regulation of myelination
    (GO:0031642)
  • Negative regulation of systemic arterial blood pressure
    (GO:0003085)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Osteoclast differentiation
    (GO:0030316)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cellular metabolic process
    (GO:0031325)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of chronic inflammatory response to antigenic stimulus
    (GO:0002876)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of fever generation
    (GO:0031622)
  • Positive regulation of fractalkine production
    (GO:0032724)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of heterotypic cell-cell adhesion
    (GO:0034116)
  • Positive regulation of humoral immune response mediated by circulating immunoglobulin
    (GO:0002925)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-18 production
    (GO:0032741)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protease binding
    (GO:0002020)
  • Protein binding
    (GO:0005515)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of immunoglobulin production
    (GO:0002637)
  • Regulation of protein phosphorylation
    (GO:0001932)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to organic substance
    (GO:0010033)
  • Response to virus
    (GO:0009615)
  • Sequestering of triglyceride
    (GO:0030730)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Tumor necrosis factor-mediated signaling pathway
    (GO:0033209)
  • Tumor necrosis factor receptor binding
    (GO:0005164)
  • Type ii interferon production
    (GO:0032609)
  • Vascular endothelial growth factor production
    (GO:0010573)

Other Information

Genular Protein ID: 2149744455

Symbol: TNFA_MOUSE

Name: Tumor necrosis factor

UniProtKB Accession Codes:

P06804 O35853 Q62326 Q91VF3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 20 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 6 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2836146

Title: Cloning and expression in Escherichia coli of the gene for mouse tumor necrosis factor.

PubMed ID: 2836146

DOI: 10.1089/dna.1988.7.193

PubMed ID: 3898078

Title: Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.

PubMed ID: 3898078

DOI: 10.1073/pnas.82.18.6060

PubMed ID: 2419912

Title: Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

PubMed ID: 2419912

DOI: 10.1073/pnas.83.6.1670

PubMed ID: 2989794

Title: Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression.

PubMed ID: 2989794

DOI: 10.1093/nar/13.12.4417

PubMed ID: 3040015

Title: Molecular cloning of genes coding for tumor necrosis factor. Complete nucleotide sequence of the genome copy of TNF-alpha in mice.

PubMed ID: 3040015

PubMed ID: 3684584

Title: Nucleotide sequence of the murine TNF locus, including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes.

PubMed ID: 3684584

DOI: 10.1093/nar/15.21.9083

PubMed ID: 7560085

Title: Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.

PubMed ID: 7560085

DOI: 10.1172/jci118239

PubMed ID: 9089109

Title: Cloning and sequencing of the Tnfa genes of three inbred mouse strains.

PubMed ID: 9089109

DOI: 10.1007/s002510050233

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 2777790

Title: Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein.

PubMed ID: 2777790

DOI: 10.1016/s0021-9258(18)71615-3

PubMed ID: 2268312

Title: Characterization of high molecular weight glycosylated forms of murine tumor necrosis factor.

PubMed ID: 2268312

DOI: 10.1016/s0006-291x(05)80895-2

PubMed ID: 3349526

Title: A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF.

PubMed ID: 3349526

DOI: 10.1016/0092-8674(88)90486-2

PubMed ID: 25586176

Title: Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Ialpha causes insulin resistance in 3T3-L1 adipocytes.

PubMed ID: 25586176

DOI: 10.1074/jbc.m114.624759

PubMed ID: 32741026

Title: Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression.

PubMed ID: 32741026

DOI: 10.1096/fj.202001197r

PubMed ID: 10089307

Title: The structure of mouse tumour-necrosis factor at 1.4 A resolution: towards modulation of its selectivity and trimerization.

PubMed ID: 10089307

DOI: 10.1107/s0907444998018435

Sequence Information:

  • Length: 235
  • Mass: 25896
  • Checksum: 16DD2A9676D68C5D
  • Sequence:
    • MSTESMIRDV ELAEEALPQK MGGFQNSRRC LCLSLFSFLL VAGATTLFCL LNFGVIGPQR 
DEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ VEEQLEWLSQ RANALLANGM 
DLKDNQLVVP ADGLYLVYSQ VLFKGQGCPD YVLLTHTVSR FAISYQEKVN LLSAVKSPCP 
KDTPEGAELK PWYEPIYLGG VFQLEKGDQL SAEVNLPKYL DFAESGQVYF GVIAL

Genular Protein ID: 610615047

Symbol: A0A0R4J210_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J210

Database IDs:

AGR 1 ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneTree 1 InterPro 5 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 219
  • Mass: 24246
  • Checksum: 55DBC52E20AA7633
  • Sequence:
    • MSTESMIRDV ELAEEALPQK MGGFQNSRRC LCLSLFSFLL VAGATTLFCL LNFGVIGPQR 
DEKFPNGLPL ISSMAQTLTL TNHQVEEQLE WLSQRANALL ANGMDLKDNQ LVVPADGLYL 
VYSQVLFKGQ GCPDYVLLTH TVSRFAISYQ EKVNLLSAVK SPCPKDTPEG AELKPWYEPI 
YLGGVFQLEK GDQLSAEVNL PKYLDFAESG QVYFGVIAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.