Genular: Defining Cellular Identity and Function

Details for: Tnfrsf11a

Gene ID: 21934

Symbol: Tnfrsf11a

Ensembl ID: ENSMUSG00000026321

Description: tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-MMU-5676594)
Adaptive immune response
(GO:0002250)
Cell surface
(GO:0009986)
Circadian temperature homeostasis
(GO:0060086)
Cytokine binding
(GO:0019955)
Cytosol
(GO:0005829)
External side of plasma membrane
(GO:0009897)
Lymph node development
(GO:0048535)
Mammary gland alveolus development
(GO:0060749)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Multicellular organism development
(GO:0007275)
Multinuclear osteoclast differentiation
(GO:0072674)
Ossification
(GO:0001503)
Osteoclast differentiation
(GO:0030316)
Plasma membrane
(GO:0005886)
Positive regulation of bone resorption
(GO:0045780)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of fever generation by positive regulation of prostaglandin secretion
(GO:0071812)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of osteoclast differentiation
(GO:0045672)
Protein binding
(GO:0005515)
Response to cytokine
(GO:0034097)
Response to interleukin-1
(GO:0070555)
Response to lipopolysaccharide
(GO:0032496)
Response to tumor necrosis factor
(GO:0034612)
Transmembrane signaling receptor activity
(GO:0004888)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Tumor necrosis factor receptor activity
(GO:0005031)

Other Information

Proteins

Tumor necrosis factor receptor superfamily member 11A

Genular Protein ID: 1608708096

Symbol: TNR11_MOUSE

Name: Tumor necrosis factor receptor superfamily member 11A

UniProtKB Accession Codes:

O35305 Q8VCT7

Database IDs:

Citations:

PubMed ID: 9367155

Title: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

PubMed ID: 9367155

DOI: 10.1038/36593

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9878548

Title: RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis.

PubMed ID: 9878548

DOI: 10.1006/bbrc.1998.9788

PubMed ID: 23478294

Title: Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.

PubMed ID: 23478294

DOI: 10.1038/cr.2013.33

PubMed ID: 20483727

Title: Structural and functional insights of RANKL-RANK interaction and signaling.

PubMed ID: 20483727

DOI: 10.4049/jimmunol.0904033

PubMed ID: 23039992

Title: RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor.

PubMed ID: 23039992

DOI: 10.1016/j.str.2012.08.030

Sequence Information:

Length: 625
Mass: 66621
Checksum: F8C1872E99511D8E
Sequence:

MAPRARRRRQ LPAPLLALCV LLVPLQVTLQ VTPPCTQERH YEHLGRCCSR CEPGKYLSSK 
CTPTSDSVCL PCGPDEYLDT WNEEDKCLLH KVCDAGKALV AVDPGNHTAP RRCACTAGYH 
WNSDCECCRR NTECAPGFGA QHPLQLNKDT VCTPCLLGFF SDVFSSTDKC KPWTNCTLLG 
KLEAHQGTTE SDVVCSSSMT LRRPPKEAQA YLPSLIVLLL FISVVVVAAI IFGVYYRKGG 
KALTANLWNW VNDACSSLSG NKESSGDRCA GSHSATSSQQ EVCEGILLMT REEKMVPEDG 
AGVCGPVCAA GGPWAEVRDS RTFTLVSEVE TQGDLSRKIP TEDEYTDRPS QPSTGSLLLI 
QQGSKSIPPF QEPLEVGEND SLSQCFTGTE STVDSEGCDF TEPPSRTDSM PVSPEKHLTK 
EIEGDSCLPW VVSSNSTDGY TGSGNTPGED HEPFPGSLKC GPLPQCAYSM GFPSEAAASM 
AEAGVRPQDR ADERGASGSG SSPSDQPPAS GNVTGNSNST FISSGQVMNF KGDIIVVYVS 
QTSQEGPGSA EPESEPVGRP VQEETLAHRD SFAGTAPRFP DVCATGAGLQ EQGAPRQKDG 
TSRPVQEQGG AQTSLHTQGS GQCAE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tnfrsf11a

Associated with

Other Information

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. PubMed ID: 9367155

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. PubMed ID: 9878548

Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. PubMed ID: 23478294

Structural and functional insights of RANKL-RANK interaction and signaling. PubMed ID: 20483727