Genular: Defining Cellular Identity and Function

Details for: Tnfrsf1a

Gene ID: 21937

Symbol: Tnfrsf1a

Ensembl ID: ENSMUSG00000030341

Description: tumor necrosis factor receptor superfamily, member 1a

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Death receptor signaling
(R-MMU-73887)
Immune system
(R-MMU-168256)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Tnfr1-induced nf-kappa-b signaling pathway
(R-MMU-5357956)
Tnfr1-induced proapoptotic signaling
(R-MMU-5357786)
Tnfr1-mediated ceramide production
(R-MMU-5626978)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Tnfs bind their physiological receptors
(R-MMU-5669034)
Tnf signaling
(R-MMU-75893)
Aortic valve development
(GO:0003176)
Apoptotic process
(GO:0006915)
Axon
(GO:0030424)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cytokine-mediated signaling pathway
(GO:0019221)
Defense response
(GO:0006952)
Defense response to bacterium
(GO:0042742)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Inflammatory response
(GO:0006954)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cardiac muscle hypertrophy
(GO:0010614)
Negative regulation of extracellular matrix constituent secretion
(GO:0003332)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of interleukin-6 production
(GO:0032715)
Plasma membrane
(GO:0005886)
Positive regulation of amide metabolic process
(GO:0034250)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic process involved in morphogenesis
(GO:1902339)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cellular metabolic process
(GO:0031325)
Positive regulation of execution phase of apoptosis
(GO:1900119)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of lipid metabolic process
(GO:0045834)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Prostaglandin metabolic process
(GO:0006693)
Protease binding
(GO:0002020)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Pulmonary valve development
(GO:0003177)
Receptor complex
(GO:0043235)
Regulation of apoptotic process
(GO:0042981)
Regulation of establishment of endothelial barrier
(GO:1903140)
Regulation of membrane lipid metabolic process
(GO:1905038)
Regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010803)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Transcription by rna polymerase ii
(GO:0006366)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Tumor necrosis factor binding
(GO:0043120)
Tumor necrosis factor receptor activity
(GO:0005031)

Other Information

Proteins

Tumor necrosis factor receptor superfamily member 1A

Genular Protein ID: 3029479231

Symbol: TNR1A_MOUSE

Name: Tumor necrosis factor receptor superfamily member 1A

UniProtKB Accession Codes:

P25118

Database IDs:

Citations:

PubMed ID: 1849278

Title: Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

PubMed ID: 1849278

DOI: 10.1073/pnas.88.7.2830

PubMed ID: 1645445

Title: Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor.

PubMed ID: 1645445

DOI: 10.1128/mcb.11.6.3020-3026.1991

PubMed ID: 1647956

Title: Cloning, expression and cross-linking analysis of the murine p55 tumor necrosis factor receptor.

PubMed ID: 1647956

DOI: 10.1002/eji.1830210710

PubMed ID: 1657766

Title: Molecular cloning and expression of the mouse Tnf receptor type b.

PubMed ID: 1657766

DOI: 10.1007/bf00211997

PubMed ID: 8188324

Title: Nucleotide sequence of the TNF type I receptor from a mouse endothelioma cell line.

PubMed ID: 8188324

DOI: 10.1007/bf00176168

PubMed ID: 8381516

Title: Genomic organization and promoter function of the murine tumor necrosis factor receptor beta gene.

PubMed ID: 8381516

DOI: 10.1016/0161-5890(93)90088-s

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24440909

Title: A novel role for the apoptosis inhibitor ARC in suppressing TNFalpha-induced regulated necrosis.

PubMed ID: 24440909

DOI: 10.1038/cdd.2013.195

PubMed ID: 30902834

Title: Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways.

PubMed ID: 30902834

DOI: 10.1074/mcp.ra118.001093

Sequence Information:

Length: 454
Mass: 50130
Checksum: 0710C2E8C3C2B6D9
Sequence:

MGLPTVPGLL LSLVLLALLM GIHPSGVTGL VPSLGDREKR DSLCPQGKYV HSKNNSICCT 
KCHKGTYLVS DCPSPGRDTV CRECEKGTFT ASQNYLRQCL SCKTCRKEMS QVEISPCQAD 
KDTVCGCKEN QFQRYLSETH FQCVDCSPCF NGTVTIPCKE TQNTVCNCHA GFFLRESECV 
PCSHCKKNEE CMKLCLPPPL ANVTNPQDSG TAVLLPLVIL LGLCLLSFIF ISLMCRYPRW 
RPEVYSIICR DPVPVKEEKA GKPLTPAPSP AFSPTSGFNP TLGFSTPGFS SPVSSTPISP 
IFGPSNWHFM PPVSEVVPTQ GADPLLYESL CSVPAPTSVQ KWEDSAHPQR PDNADLAILY 
AVVDGVPPAR WKEFMRFMGL SEHEIERLEM QNGRCLREAQ YSMLEAWRRR TPRHEDTLEV 
VGLVLSKMNL AGCLENILEA LRNPAPSSTT RLPR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tnfrsf1a

Associated with

Other Information

Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. PubMed ID: 1849278

Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor. PubMed ID: 1645445

Cloning, expression and cross-linking analysis of the murine p55 tumor necrosis factor receptor. PubMed ID: 1647956

Molecular cloning and expression of the mouse Tnf receptor type b. PubMed ID: 1657766

Nucleotide sequence of the TNF type I receptor from a mouse endothelioma cell line. PubMed ID: 8188324

Genomic organization and promoter function of the murine tumor necrosis factor receptor beta gene. PubMed ID: 8381516

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel role for the apoptosis inhibitor ARC in suppressing TNFalpha-induced regulated necrosis. PubMed ID: 24440909

Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways. PubMed ID: 30902834